Structure, Function and Regulation of TOR complexes from Yeasts to Mammals

Structure, Function and Regulation of TOR complexes from Yeasts to Mammals

Part A

1st Edition - March 13, 2010

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  • Editors: Michael Hall, Fuyuhiko Tamanoi
  • Hardcover ISBN: 9780123815392
  • eBook ISBN: 9780123815408

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Cell growth is highly regulated and is controlled by the TOR signaling network. Dysfunction of signaling pathways controlling cell growth results in cells of altered sizes and in turn causes developmental errors and a wide range of pathological conditions. An understanding of the TOR signaling network may lead to novel drugs for the treatment of, for example, cancer, diabetes, inflammation, muscle atrophy, learning disabilities, depression, obesity and aging. There has been an explosion of knowledge in this area in recent years and this volume provides an in-depth review of our current knowledge of TOR complexes by the leaders in the field.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Biochemists, cell biologists, molecular biologists, biophysicists.

Table of Contents

  • Chapter 1: TOR complexes: composition, structure and phosphorylation

    Mike Hall

    Chapter 2: Regulation of TOR signaling in mammals

    Dudley W. Lamming and David Sabatini

    Chapter 3: Rheb G-protein and activation of mTORC1

    Fuyu Tamanoi

    Chapter 4: Regulation of TOR Complex1 by amino acids through small GTPases

    Joe Avruch, Xiaomeng Long, Yenshou Lin, Sara Ortiz-Vega, Joseph Rapley, and Noriko Oshiro

    Chapter 5: Rag GTPases in TORC1 activation and nutrient signaling

    Li Li and Kun-Liang Guan

    Chapter 6: Amino Acid Regulation of hVps34 and mTORC1 signaling

    Pawan Gulati and George Thomas

    Chapter 7: mTORC1 and cell cycle control

    Chris Proud

    Chapter 8: AGC Kinases in mTOR Signaling

    Estela Jacinto

    Chapter 9: TORC1 signaling in budding yeast

    Robbie Loewith

    Chapter 10: TORC2 and sphingolipid biosynthesis and signaling: Lessons from budding yeast

    Ted Powers

    Chapter 11: TORC1 signaling in the budding yeast endomembrane system and control of cell-cell adhesion in pathogenic fungi

    Robert J. Bastidas and Maria Cardenas-Corona

    Chapter 12: TOR and sexual development in fission yeast

    Yoko Otsubo and Masayuki Yamamoto

    Chapter 13: Fission yeast TOR and rapamycin

    Ronit Weisman

    Chapter 14: Structure of TOR complexes in fission yeast

    Junko Kanoh and Mitsuhiro Yanagida

    Chapter 15: The TOR complex and signaling pathway in plants

    Christophe Robaglia, Bruce Veit and Christian Meyer

    Chapter 16: Dysregulation of TOR Signaling in Tuberous Sclerosis and Lymphangioleiomyomotosis

    Elizabeth Henske

    Chapter 17: Chemistry and Pharmacology of Rapamycin and its Derivatives

    Robert T. Abraham, James J. Gibbons and Edmund I. Graziani

Product details

  • No. of pages: 420
  • Language: English
  • Copyright: © Academic Press 2010
  • Published: March 13, 2010
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123815392
  • eBook ISBN: 9780123815408

About the Serial Volume Editors

Michael Hall

Affiliations and Expertise

Biozentrum, University of Basel, Switzerland

Fuyuhiko Tamanoi

Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997.

Affiliations and Expertise

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, USA

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