Structure and Metabolic Mechanisms

Structure and Metabolic Mechanisms

1st Edition - January 1, 1977

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  • Editor: Walter Lovenberg
  • eBook ISBN: 9780323149525

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Description

Iron-Sulfur Proteins, Volume III: Structure and Metabolic Mechanisms focuses on numerous advances that have been made in the vital role of iron-sulfur proteins in biological processes. Of the 10 chapters in this book, five chapters present advances in biochemical areas and the other five chapters discuss some of the elegant physical studies made. This book begins with a description of the nitrogenase gene and the molecular mechanism of this complex enzyme. It then centers on the role of iron-sulfur proteins in mammalian mitochondrial function, as well as on the mechanism of biosynthesis and the function of these proteins in formate metabolism. Different approaches that have yielded advances in the understanding of the iron-sulfur clusters are also shown. This book also gives an in-depth discussion on the theoretical aspects of the redox properties of iron-sulfur proteins.

Table of Contents


  • List of Contributors

    Preface

    Contents of Other Volumes

    1. Nitrogenase-Derepressed Mutants of Klebsiella pneumoniae

    I. Introduction

    II. Glutamine Synthetase as Regulatory Protein

    III. Nitrogenase-Derepressed Mutants

    IV. Discussion and Summary

    References

    2. Current Topics and Problems in the Enzymology of Nitrogenase

    I. Introduction

    II. Composition and Structure of Nitrogenase Protein Components

    III. Interaction of MgATP and the Fe Protein

    IV. Sequence of Electron Transfers between Nitrogenase Components

    V. Structural and Mechanistic Hypotheses

    References

    3. Iron-Sulfur Centers of the Mitochondrial Electron Transfer System—Recent Developments

    I. Introduction

    II. Iron-Sulfur Centers of the Mitochondrial Electron Transfer System

    III. Relation of Iron-Sulfur Centers to Energy Conservation

    IV. Outlook

    References

    4. Biosynthesis of Iron-Sulfur Proteins

    I. Introduction

    II. Bacterial Protein Synthesis

    III. Regulation of Synthesis of Ferredoxin

    IV. Conversion of Apoferredoxin to Holo- or Native Ferredoxin

    V. Synthesis of Specific Proteins in Vitro

    VI. Immunological Studies with Clostridial Ferredoxin

    VII. Enzymatic Assays for Ferredoxin

    VIII. Synthesis of Clostridial Ferredoxin or Apoferredoxin in Vitro

    References

    5. Role of Iron-Sulfur Proteins in Formate Metabolism

    I. Introduction

    II. Role of Formate in Metabolism

    III. Ferredoxin and Formate Metabolism

    IV. Formate Dehydrogenases and Formate Metabolism

    V. Concluding Remarks

    References

    6. X-Ray Analysis of High-Potential Iron-Sulfur Proteins and Ferredoxins

    I. Introduction

    II. Fe4S4* Active Centers and the Three-State Hypothesis

    III. Comparison of the Protein-Bound and Synthetic Fe4S4* Clusters

    IV. Characteristic Features of the Cluster Binding Cavities

    V. Analysis of Reduced versus Oxidized HiPIP

    VI. Conclusions and Review

    References

    7. Synthetic Analogues of the Active Sites of Iron-Sulfur Proteins

    I. Introduction

    II. Synthesis and Structures of 1-Fe, 2-Fe, and 4-Fe Active-Site Analogues

    III. Physical Properties of Analogues

    IV. Chemical Reactivity of Analogues

    V. Iron-Sulfur Units as Redox Centers

    VI. Perspectives and Conclusions

    References

    8. Evidence from Mössbauer Spectroscopy and Magnetic Resonance on the Active Centers of the Iron-Sulfur Proteins

    I. Introduction

    II. Spectroscopy of the Active Center

    III. Proteins with 1 Fe Centers

    IV. Proteins with 2 Fe-2 S* Centers

    V. Proteins with 4 Fe-4 S* Centers

    VI. Conclusions

    References

    9. Redox Mechanisms of Iron-Sulfur Proteins

    I. Introduction

    II. Recent Development in Simple Redox Chemistry

    III. Redox Dynamics of Structurally Characterized Iron-Sulfur Proteins

    IV. Survey of the Redox Behavior of Structurally Less Characterized Iron-Sulfur Proteins

    References

    10. Recent Mössbauer Results of Some Iron-Sulfur Proteins and Model Complexes

    I. Introduction

    II. Rubredoxin

    III. The MoFe Protein of Nitrogenase

    IV. Model Compounds for Rubredoxin and 4 Fe-4 S* Clusters

    References

    Author Index

    Subject Index






Product details

  • No. of pages: 460
  • Language: English
  • Copyright: © Academic Press 1977
  • Published: January 1, 1977
  • Imprint: Academic Press
  • eBook ISBN: 9780323149525

About the Editor

Walter Lovenberg

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