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Structure and Function of the Extracellular Matrix - 1st Edition - ISBN: 9780128197165

Structure and Function of the Extracellular Matrix

1st Edition

A Multiscale Quantitative Approach

Author: Bela Suki
Paperback ISBN: 9780128197165
Imprint: Academic Press
Published Date: 1st November 2021
Page Count: 250
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Description

Structure and Function of the Extracellular Matrix: A Multiscale Quantitative Approach introduces biomechanics and biophysics with applications to understand the biological function of the extracellular matrix in health and disease. A general multiscale approach is followed by investigating behavior from the scale of single molecules, through fibrils and fibers, to tissues of various organ systems. Through mathematical models and structural information, quantitative description of the extracellular matrix function is derived with tissue specific details. The book introduces the properties and organization of extracellular matrix components and quantitative models of the matrix, and guides the reader through predicting functional properties.

This book integrates evolutionary biology with multiscale structure to quantitatively understand the function of the extracellular matrix. This approach allows a fresh look into normal functioning as well as the pathological alterations of the extracellular matrix. Professor Suki’s book is written to be useful to undergraduates, graduate students, and researchers interested in the quantitative aspects of the extracellular matrix. Researchers working in mechanotransduction, respiratory and cardiovascular mechanics, and multiscale biomechanics of tendon, cartilage, skin, and bone may also be interested in this book.

Key Features

  • Examines the evolutionary origins and consequences of the extracellular matrix
  • Delivers the first book to quantitatively treat the extracellular matrix as a multiscale system
  • Presents problems and a set of computational laboratory projects in various chapters to aid teaching and learning
  • Provides an introduction to the properties and organization of the extracellular matrix components

Readership

Upper level undergraduates, graduate students, post-doctoral fellows, and researchers working in the general area of mechanotransduction, respiratory and cardiovascular mechanics, and multiscale biomechanics of tendon, cartilage, skin and bone

Table of Contents

  1. Introduction and overview of the extracellular matrix and its relation to cells
    2. Building blocks, evolution and organization of collagen from amino acids to fibrous tissue
    3. Functional properties of collagen from molecules to tissue in normal and diseased states: interpretation with analytic and computational models
    4. Building blocks, evolution and organization of elastin from amino acids to fibrous tissue
    5. Functional properties of elastin from molecules to tissue in normal and diseased states: interpretation with the use of modeling
    6. Building blocks, evolution, organization and function of microfibrils
    7. Mechanical properties of microfibrils and their roles in development and disease
    8. Building blocks, evolution, organization and function of proteoglycans
    9. Mechanical and electrical properties of proteoglycans and their relation to other extracellular proteins: computational modeling
    10. Relation of the extracellular matrix components to each other and cells: mechanical interactions and mechanotransduction
    11. Extracellular matrix homeostasis: modeling the mechanical properties of single molecules, fibrils and fibers
    12. Modeling the mechanical properties of network of fibrils and fibers embedded in proteoglycans
    13. Basic concepts in multiscale modeling: examples of tendon, vessels, lung and cartilage
    14. Modeling the repair and digestion of fibers and networks
    15. General multiscale modeling of tissue failure: implications for tendon rupture, aneurysm and emphysema
    16. Application of mathematical modeling to tissue engineering and regenerative medicine

Details

No. of pages:
250
Language:
English
Copyright:
© Academic Press 2021
Published:
1st November 2021
Imprint:
Academic Press
Paperback ISBN:
9780128197165

About the Author

Bela Suki

He earned an MS in physics (1982) and PhD in biomechanics and respiratory physiology (1987). He is now a professor of Biomedical Engineering at Boston University. Over the last 3 decades, he has worked in various areas of the life sciences including respiratory and vascular physiology and biomechanics, cell and tissue mechanics, computational fluid and solid mechanics applied to various physiological problems and complexity in physiology and biology. He has published over 230 papers, reviews and book chapters. He developed 3 relevant courses: 1) Structure and function of the extracellular matrix (BE 549); 2) Respiratory and cardiovascular engineering (BE 508); and 3) Nonlinear systems in biomedical engineering (BE 567).

Affiliations and Expertise

Professor of Biomedical Engineering, Department of Biomedical Engineering, Boston University, USA

Ratings and Reviews