Structure and function of Collagen types

Structure and function of Collagen types

1st Edition - August 26, 1987

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  • Editor: Richard Maynes
  • eBook ISBN: 9780323155717

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Structure and Function of Collagen Types is a collection of articles that reviews the different types of collagens (Type I to XI). Each article focuses on a particular type of collagen and written by leading investigators in the collagen field. The book begins with a review of the fibril forming collagens (types I, II, and III) and traces the early work on the structure of these collagens to our knowledge of the structure of the collagen genes. This chapter is followed by a detailed description of type IV (basement membrane) collagen. Chapter 3 addresses the biosynthesis and chain assembly of type V collagen. The evidence that type VI collagen is assembled to form tetramers is presented in chapter 4. The subsequent article shows that type VII collagens are assembled to form partially overlapping dimers. Chapter 6 presents the structure of type VIII collagen. Chapters 7, 8, and 9 discuss the structure and characteristics of collagens that are synthesized by cartilaginous tissues and these are designated as type IX, type X, and type XI. The final chapter reviews the recombinant DNA techniques used to investigate collagen structure and the possibility to recognize new collagen types from a cDNA library. Physiologists, cell biologists, and researchers in the field of collagen will find the text very insightful.

Table of Contents

  • Preface

    The Classical Collagens: Types I, II, and III

    I. Introduction

    II. Early Investigations

    III. Electron Microscopic Investigations

    IV. Protein Chemical Investigation

    V. Biochemical Investigations

    VI. The Covalent Structure of the Procollagens

    VII. The Gene Structure of Collagens I, II, and III

    VIII. Synopsis


    Type IV Collagen

    I. Introduction

    II. Structure

    III. Molecular Biology

    IV. Biosynthesis

    V. Immunochemistry

    VI. Degradation

    VII. Involvement in Disease Processes

    VIII. Interactions with Cells and Other Proteins

    IX. Appendix A: αl(IV) Amino Acid Sequence

    X. Appendix B: α2(IV) Amino Acid Sequence


    Type V Collagen

    I. Introduction

    II. Compositions of Collagens V

    III. Nucleotide Sequences of Procollagens V

    IV. Structure of Procollagens V

    V. Biosynthesis

    VI. Secretion of Procollagens V and Processing

    VII. Location of Collagens V in the Extracellular Matrix

    VIII. Other Properties of Collagens V

    IX. Occurrence of Collagens V

    X. Conclusions


    Type VI Collagen

    I. Introduction

    II. Protein Chemistry and Macromolecular Organization

    III. Biosynthesis

    IV. Immunology

    V. Tissue Distribution

    VI. Possible Functions and Involvement in Disease


    Type VII Collagen

    I. Introduction

    II. The Structure of Type VII Collagen

    III. The Function of Type VII Collagen

    IV. Pathological Findings Related to Disruptions of the Anchoring Fibril Network


    Type VIII Collagen

    I. Introduction

    II. Type VIII Collagen from Cells in Culture

    III. Type VIII Collagen from Tissue: Descemet's Membrane

    IV. Structure of Type VIII Collagen

    V. Summary and Conclusions


    Type IX Collagen

    I. Introduction

    II. The Pepsin-Resistant Fragments

    III. The Intact Type IX Molecule

    IV. The Structure of Type IX Collagen

    V. Biosynthesis and Cleavage of the Intact Molecule by Proteases

    VI. Immunofluorescent Localization of Type IX Collagen in Cartilage Matrix

    VII. Summary and Conclusions


    Type X Collagen

    I. Introduction

    II. Initial Discovery

    III. Source of Type X Collagen

    IV. Isolation of Type X Collagen

    V. Chromatography of Type X Collagen

    VI. Amino Acid Composition of Type X Collagen

    VII. Cyanogen Bromide Cleavage of Type X Collagen

    VIII. Thermal Stability of Type X Collagen

    IX. Vertebrate Collagenase Susceptibility of Type X Collagen

    X. Molecular Structure of Type X Collagen

    XI. Biosynthesis of Type X Collagen

    XII. Immunohistochemical Localization of Type X Collagen with a Monoclonal Antibody

    XIII. Biochemical Localization of Type X Collagen

    XIV. Functions of Type X Collagen

    XV. Unresolved Questions about Type X Collagen


    Type XI or 1α2α3α Collagen

    I. Introduction

    II. Nomenclature

    III. Isolation and Analysis

    IV. Structure

    V. Biosynthesis

    VI. Protease Susceptibility

    VII. Immunochemistry

    VIII. Pathology

    IX. Possible Functions


    Analysis of Collagen Structure by Molecular Biology Techniques

    I. Introduction

    II. Cloning Strategies

    III. Strategies for Identifying Collagen cDNA and Genomic Clones

    IV. Structural Protein Information that can be Easily Obtained from Cloned DNA

    V. Further Use of DNA Probes

    VI. Summary and Conclusions



Product details

  • No. of pages: 328
  • Language: English
  • Copyright: © Academic Press 1987
  • Published: August 26, 1987
  • Imprint: Academic Press
  • eBook ISBN: 9780323155717

About the Editor

Richard Maynes

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