Structural Studies on Nucleic acids and Other Biopolymers

1st Edition - January 1, 1973
Editor: J Duchesne
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 5 2 5 8 - 7

Physico-chemical Properties of Nucleic Acids, Volume II basically deals with the structural studies on nucleic acids and other biopolymers. This volume gives much emphasis on… Read more

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Physico-chemical Properties of Nucleic Acids, Volume II basically deals with the structural studies on nucleic acids and other biopolymers. This volume gives much emphasis on conformational changes using spectroscopic techniques and also on methods of thermodynamics and hydrodynamics. Volume II begins with Chapter 10 as continuation of Volume I and discusses the infrared and Raman spectroscopy of nucleic acids and polynucleotides. Chapter 11 delves further into the topic of infrared and Raman spectra particularly the vibrations in the base-residues. This volume also highlights the topic of RNA, where the structure of viral RNA and nuclear magnetic resonance studies of transfer RNAs in solution are covered. The last two chapters discuss the concept of thermodynamic and hydrodynamic properties of conformation transitions and changes. This volume caters to both students and researchers in various fields of science, such as biology, chemistry, molecular biology, biophysics, and microbiology.

Contributors

Preface

Foreword

Contents Vol. 1

Contents Vol. 3

10. Structural Studies of Nucleic Acid and Polynucleotides by Infrared and Raman Spectroscopy

I. Introduction

II. Infrared Studies of Nucleic Acid Structure

III. Raman Spectroscopy and Nucleic Acid Structure

References

11. Infrared and Raman Spectra of Nucleic Acids—Vibrations in the Base Residues

I. Introduction

II. The Spectra of the Four-Base Residues

III. Data for Characterizing Raman Lines and Infrared Absorption Bands

IV. Normal Coordinate Treatment

V. Characterization of each Raman line or Infrared Band

VI. Effects of Inter-Base Interactions

Acknowledgments

References

12. Conformation of Nucleic Acids, Oligo- and Polynucleotides by Circular Dichroism Investigations

I. Introduction

II. Mononucleosides

III. Analysis of Polynucleotide CD

IV. Nucleic Acids

References

13. Nuclear Magnetic Resonance Studies of Transfer RNAs in Solution

I. Introduction

II. The Interaction of Purine with E. coli tRNAfMet

III. Organic Solvent Denaturation of Transfer RNA

IV. Summary

Acknowledgments

References

14. The Structure of Viral RNA

I. Viral RNA Genomes

II. Chemical Identification of Endgroups

III. The Primary Structure of Viral RNA

IV. Sequences of the Viral RNA not Involved in Translation

V. Sequences of the Viral RNA which Contain the Message for Polypeptide Synthesis

VI. Physical Structure of the Viral RNA

Note Added in Proof

Acknowledgments

References

15. Thermodynamics and Kinetics of Conformational Transitions in Oligonucleotides and tRNA

I. Introduction

II. Single Strand Stacking

III. Base Pairing in Oligonucleotides and tRNA Fragments

IV. Conformational Changes in tRNA

V. Biological Implications

Acknowledgments

Addendum

References

16. Hydrodynamic Properties and Conformational Changes of Linear Native DNA

I. Introduction

II. Theoretical Aspects of DNA Hydrodynamics

III. Special Experimental Aspects of DNA Hydrodynamics and Molecular Weight Determination

IV. Hydrodynamic Behavior and DNA Molecular Weight

V. DNA as a Polyelectrolyte

VI. Analysis of Induced DNA Conformational Changes

Acknowledgments

References

Author Index

Subject Index