5th Edition

Pathophysiology, Diagnosis, and Management (Expert Consult - Online and Print)

Authors: J. Mohr James Grotta Philip Wolf Michael Moskowitz Marc Mayberg Rudiger Von Kummer
Hardcover ISBN: 9781416054788
eBook ISBN: 9781437737806
Imprint: Saunders
Published Date: 31st March 2011
Page Count: 1520


First published in 1986 under the editorial direction of Dr. Henry J.M. Barnett, Stroke: Pathophysiology, Diagnosis, and Management continues to provide the dependable, current answers you need to effectively combat the increasing incidence of this disease. Dr. J.P. Mohr, together with new associate editors Philip A. Wolf, James C. Grotta, Michael A. Moskowitz, Marc Mayberg, and Rüdiger von Kummer as well as a multitude of expert contributors from around the world, offer you updated and expanded coverage of mechanisms of action of commonly used drugs, neuronal angiogenesis and stem cells, basic mechanisms of spasm and hemorrhage, prevention of stroke, genetics/predisposing risk factors, and much more, equipping you to understand the latest scientific discoveries and make effective use of the newest approaches to diagnosis and treatment. Plus, a new organization and new full-color images make diagnosis easier and more efficient, and full-text online access at allows you to rapidly search this indispensable reference from any computer.

Key Features

  • Gain fresh perspectives and up-to-date insights from the world’s leading authorities on the pathophysiology, diagnosis, and management of stroke.
  • Access the comprehensive, expert clinical guidance you need to recognize the clinical manifestations of stroke, use the latest laboratory and imaging studies to arrive at a diagnosis, and generate an effective medical and surgical treatment plan.

Table of Contents

section one


Michael A. Moskowitz

Vascular Biology and Atherosclerosis of Cerebral Arteries 03

Alyson A. Miller, Christopher G. Sobey

The Cerebral Microvasculature and Responses to Ischemia 16

Gregory J. del Zoppo, Gerhard F. Hamann

Mechanisms of Thrombosis and Thrombolysis 29

Gregory J. del Zoppo, Mary A. Kalafut

Cerebral Blood Flow and Metabolism in Human Cerebrovascular Disease 44

Allyson R. Zazulia, Joanne Markham, William J. Powers

Histopathology of Cerebral Ischemia 68


Molecular and Cellular Mechanisms of Ischemia-Induced Neuronal Death 75

Dimitry Ofengeim, Takahiro Miyawaki, R. Suzanne Zukin

Apoptosis and Related Mechanisms in Cerebral Ischemia 107

Turgay Dalkara, Michael A. Moskowitz

Molecular Pathophysiology of White Matter Anoxic-Ischemic Injury 122

Bruce R. Ransom, Mark P. Goldberg, Selva Baltan

Cerebral Ischemia and Inflammation 138

Costantino Iadecola, Takato Abe, Alexander Kunz, John Hallenbeck

Intracellular Signaling: Mediators and Protective Responses 154

Valina L. Dawson, Ted M. Dawson

Enhancing Brain Reorganization and Recovery of Function after Stroke 162

Michael Chopp, Zheng Gang Zhang

Genetics and Vascular Biology of Brain Vascular Malformations 169

Helen Kim, Ludmila Pawlikowska, William L. Young

section two

Epidemiology and Prevention

Philip A. Wolf

Distribution of Stroke: Heterogeneity by Age, Race, and Sex 189

Virginia J. Howard, George Howard

Epidemiology of Stroke 198

Philip A. Wolf, William B. Kannel

Prognosis after Stroke 219

TATJANA Rundek, Ralph L. Sacco

16 Primary Prevention of Stroke 242


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About the Author

J. Mohr

Affiliations and Expertise

Daniel Sciarra Professor of Neurology, Department of Neurology, Columbia University, New York, NY, USA.

James Grotta

Professor of Neurology, Chairman, Department of Neurology, University of Texas Medical School at Houston; Director, Stroke Program, Memorial Hermann - Texas Medical Center, Houston, TX

Affiliations and Expertise

Director, Stroke Program, Memorial Hermann - Texas Medical Center; Professor of Neurology; Chairman, Department of Neurology, University of Texas Medical School at Houston, Houston, TX, USA.

Philip Wolf

Affiliations and Expertise

Professor of Neurology, Medicine, and Public Health, Boston University School of Medicine; Principal Investigator, Framingham Heart Study, Boston, MA, USA.

Michael Moskowitz

Affiliations and Expertise

Professor of Neurology, Harvard-MIT Division of Health Science and Technology, Boston, MA, USA.

Marc Mayberg

Affiliations and Expertise

Executive Director, Seattle Neuroscience Institute at Swedish Medical Center, Seattle, WA, USA.

Rudiger Von Kummer

Affiliations and Expertise

Professor of Diagnostic Radiology/ Neuroradiology; Head, Department of Neuroradiology, Technische Universitat Dresden; Director, Dresden University Stroke Center, Dresden, Germany