Stroke Part I: Basic and epidemiological aspects - 1st Edition - ISBN: 9780444520036, 9780702035388

Stroke Part I: Basic and epidemiological aspects, Volume 92

1st Edition

Editors: Marc Fisher
Hardcover ISBN: 9780444520036
eBook ISBN: 9780702035388
Imprint: Elsevier
Published Date: 17th November 2008
Page Count: 464
Tax/VAT will be calculated at check-out

Institutional Access


Table of Contents

Section 1: Historical perspective:
The history of stroke and cerebrovascular disease.

Section 2: Basic science overview and pathology:
The ischemic cascade and mediators of ischemic injury. Animal models of ischemic stroke. Cerebral blood flow and ischemic penumbra. Neuropathology of ischemic brain injury. Reperfusion injury after stroke: neurovascular proteases and the blood-brain barrier. Gene induction, protein synthesis and related issues. Effects of gender and sex steroids on ischemic injury. Ischemic tolerance as an active and intrinsic neuroprotective mechanism. Vascular endothelium and the blood-brain barrier. A cerebrovascular perspective of atherosclerosis. Blood coagulation and fibrinolysis: mechanisms of thrombosis. Anatomy of the circulation of the brain and spinal cord. Cerebral vascular dysregulation in the ischemic brain. Experimental models in intracerebral hemorrhage.

Section 3: Clinical epidemiology:
The worldwide burden of stroke: current status and future projections. Stroke among women, ethnic groups, young adults and children. Clinical genetic issues in stroke.
Costs and health care system issues. Epidemiological implications of primary and secondary stroke prevention. Stroke recurrence and prognosis after stroke.


Description

Section 1: Historical perspective:
The history of stroke and cerebrovascular disease.

Section 2: Basic science overview and pathology:
The ischemic cascade and mediators of ischemic injury. Animal models of ischemic stroke. Cerebral blood flow and ischemic penumbra. Neuropathology of ischemic brain injury. Reperfusion injury after stroke: neurovascular proteases and the blood-brain barrier. Gene induction, protein synthesis and related issues. Effects of gender and sex steroids on ischemic injury. Ischemic tolerance as an active and intrinsic neuroprotective mechanism. Vascular endothelium and the blood-brain barrier. A cerebrovascular perspective of atherosclerosis. Blood coagulation and fibrinolysis: mechanisms of thrombosis. Anatomy of the circulation of the brain and spinal cord. Cerebral vascular dysregulation in the ischemic brain. Experimental models in intracerebral hemorrhage.

Section 3: Clinical epidemiology:
The worldwide burden of stroke: current status and future projections. Stroke among women, ethnic groups, young adults and children. Clinical genetic issues in stroke.
Costs and health care system issues. Epidemiological implications of primary and secondary stroke prevention. Stroke recurrence and prognosis after stroke.

Key Features

  • A comprehensive resource on stroke, prevention techniques, diagnosis, and treatment modalities
    Illuminating and insightful information on the pathophysiological basis of stroke
    A thorough examination of the rapid advancements made in the field of cerebrovascular disorders and their applications to stroke

Readership

Neurologists
Neuroscience research workers


Details

No. of pages:
464
Language:
English
Copyright:
© Elsevier 2009
Published:
Imprint:
Elsevier
eBook ISBN:
9780702035388
Hardcover ISBN:
9780444520036

About the Editors

Marc Fisher Editor

Affiliations and Expertise

Professor of Neurology and Radiology, University of Massachusetts Medical School, Worcester, MA, USA