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Stress Resilience - 1st Edition - ISBN: 9780128139837, 9780128139844

Stress Resilience

1st Edition

Molecular and Behavioral Aspects

Editor: Alon Chen
eBook ISBN: 9780128139844
Paperback ISBN: 9780128139837
Imprint: Academic Press
Published Date: 31st October 2019
Page Count: 390
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Stress Resilience: Molecular and Behavioral Aspects presents the first reference available on the full-breadth of cutting-edge research being carried out in this field. It includes a wide range of basic molecular knowledge on the potential associations between resilience phenomenon and biochemical balance, but also focuses on the molecular and cellular mechanisms underlying stress resilience. World-renowned experts provide chapters that cover everything from the neural circuits of resilience, the effects of early-life adversity, and the transgenerational inheritance of resilience.

This unique and timely book will be a go-to resource for neuroscientists and biological psychiatrists who want to improve their understanding of the consequences of stress and on how some people are able to avoid it.

Key Features

  • Approaches resilience as a process rather than as a static trait
  • Provides basic molecular knowledge on the potential associations between resilience phenomenon and biochemical balance
  • Presents thorough coverage of both the genetic and environmental factors that contribute to resilience


Advanced students and researchers in biological psychiatry, behavioral neuroscience, cognitive neuroscience, neuroendocrinology, and psychology

Table of Contents

  1. A life-course, epigenetic perspective on resilience in brain and body
    2. Cognitive and behavioral components of resilience to stress
    3. Resilience as a process instead of a trait
    4. The brain mineralocorticoid receptor: A resilience factor for psychopathology?
    5. GABAB receptors and stress resilience: A tale of two isoforms
    6. Sex differences in the programming of stress resilience
    7. Active resilience in response to traumatic stress
    8. Rhythms of stress resilience
    9. Mitochondrial function and stress resilience
    10. Understanding resilience: Biological approaches in at-risk populations
    11. Stress resilience as a consequence of early-life adversity
    12. Mechanisms by which early-life experiences promote enduring stress resilience or vulnerability
    13. Child abuse and neglect: Stress responsivity and resilience
    14. How genes and environment interact to shape risk and resilience to stress-related psychiatric disorders
    15. Molecular characterization of the resilient brain: Transcriptional and epigenetic mechanisms
    16. The role of the CRF-Urocortin system in stress resilience
    17. Intergenerational transmission of stress vulnerability and resilience
    18. stress and its effects across generations
    19. Corticolimbic stress-regulatory circuits, hypothalamo-pituitary-adrenocortical adaptation and resilience
    20. Biomarkers of resilience and susceptibility in rodent models of stress
    21. Maladaptive learning and the amygdala - prefrontal circuit
    22. Endocannabinoid signaling and stress resilience


No. of pages:
© Academic Press 2019
31st October 2019
Academic Press
eBook ISBN:
Paperback ISBN:

About the Editor

Alon Chen

Alon Chen

Prof. Alon Chen is President-Elect of the Weizmann Institute of Science and will begin his term on Dec. 1, 2019. He was Head of the Department of Neurobiology from 2016-2019. He is also a Director and Scientific Member at the Max Planck Institute of Psychiatry, Munich, Germany and serves as the Head of the Max Planck Society - Weizmann Institute of Science Laboratory for Experimental Neuropsychiatry and Behavioral Neurogenetics. He is an adjunct Professor at the Medical School of the Ludwig Maximilian University, Munich. Prof. Chen received a BSc in Biological Studies, with distinction, from Ben-Gurion University in 1995, and a PhD from the Weizmann Institute of Science in 2001 (Direct PhD Program, with distinction). During his PhD studies, Prof. Chen also received an MBA from Ben-Gurion University. He was a postdoctoral fellow at the Salk Institute for Biological Studies in California, where he started researching stress. In 2005, he joined the faculty of the Weizmann Institute, in the Department of Neurobiology. At the Weizmann Institute, he is the incumbent of the Vera and John Schwartz Family Professorial Chair. Prof. Chen’s research focuses on the neurobiology of stress, particularly the mechanisms by which the brain regulates the response to stressful challenges and how this response is linked to psychiatric disorders. The collective long-term goal of his research is to elucidate the pathways and mechanisms by which stressors are perceived, processed, and transduced into neuroendocrine and behavioral responses under healthy and pathological conditions. His lab has made significant discoveries in his field, including fundamental aspects of the organism’s stress response and actions that link specific stress-related genes, epigenetic mechanisms, and brain circuits with anxiety disorders, depression, eating disorders, and the metabolic syndrome. Prof. Chen and his team use both genetic mouse models and human patients to ultimately create the scientific groundwork for therapeutic interventions to treat stress-related behavioral and physiological disorders. Prof. Chen is known for his excellent communication and interpersonal skills, strong leadership aptitude, and the ability to identify opportunities and to convert challenges into innovative solutions.

Affiliations and Expertise

Head, Max Planck Society–Weizmann Institute of Science Laboratory for Experimental Neuropsychiatry and Behavioral Neurogenetics Head, Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel Director, Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany


"Hans Selye, in his seminal 1936 note to Nature, introduced the “general adaptation syndrome”. That is, the ability of the organism to adapt itself to new conditions: the basis for our understanding of stress resilience. Alon Chen (Editor), a brilliant stress neuroscientist, has recruited top experts to submit 22 chapters that make this book a valuable, cutting edge contribution to stress resilience. I strongly commend “Stress Resilience” for fundamental and clinical research scientists as well as students and clinicians, especially in the fields of Neuroscience and molecular neurobiology and genetics, Neurology, Medicine, Endocrinology, Psychiatry, Psychology and related disciplines." -- George Fink (MD, DPhil, FRCPE, FRSB, FRSE) Professorial Research Fellow, the Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia

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