A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought and/or good fortune give rise to successful completion of a project. In this book we learn how synthesis is really done and are educated, challenged and inspired by these stories, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world.
- Presents state-of-the-art developments in organic synthesis
- Provides insight and offers new perspective to problem-solving
- Written by leading experts in the field
Organic chemists; academic libraries, chemical and pharmaceutical companies
Chapter 1. The Total Synthesis Of Luzopeptins (M.A. Ciufolini).
Chapter 2. Synthesis of Geldanamycin Using Glycolate Aldol Reactions (M.B. Andrus et al.).
Chapter 3. From Methylene Bridged Glycoluril Dimers To Cucurbit[N]Uril Analogs With Some Detours Along The Way (L. Isaacs, J. Lagona).
Chapter 4. Application Of Silicon-Assisted Intramolecular Cross-Coupling In Total Synthesis Of (+)-Brasilenyne (S.E. Denmark, Shyh-Ming Yang).
Chapter 5. Samarium(II) Promoted Ketyl Olefin Cyclizations Applied To The Total Syntheses Of (-)-Steganone And (+)-Isoschizandrin (G.A. Molander, K.M. George).
Chapter 6. The Synthesis Of Polycavernoside A. An Example Of Conformationally Guided Macrolactonization (P.R. Blakemore, J.D. White).
Chapter 7. First Total Synthesis Of Several Natural Products Based On Alkyne-Co2(Co)6 Complexes (Chisato Mukai).
Chapter 8. Total Synthesis Of Myriaporones 1, 3, and 4 (R.E. Taylor et al.).
Chapter 9. Adventures In Natural Product Synthesis: From Deep Sea Sponge To Pilot Plant. The Large Scale Total Synthesis Of The Marine Natural Product (+)-Discodermolide (S.J. Mickel).
Chapter 10. Synthesis Of Aprepitant (T.D. Nelson).
Chapter 11. Total Synthesis And Mechanism Of Action Studies On The Antitumor Alkaloid,(-)-Agelastatin A (K.J. Hale, M.M. Domostoj).
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- © Academic Press 2005
- 20th July 2005
- Academic Press
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@qu: "This book is a chronicle of synthetic problems and strategies written by leading organic chemists, who give their own personal accounts of the practice of organic synthesis. It is part lab. notes and memoir and should be an interesting read for both organic chemistry students and practitioners alike." @source: J. AM. CHEM. SOC, Vol. 128, no. 10, 2006