A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought and/or good fortune give rise to successful completion of a project. In this book we learn how synthesis is really done and are educated, challenged and inspired by these stories, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world.
- Presents state-of-the-art developments in organic synthesis
- Provides insight and offers new perspective to problem-solving
- Written by leading experts in the field
Organic chemists; academic libraries, chemical and pharmaceutical companies
chapter 1 TOTAL SYNTHESIS OF RK-397TOTAL SYNTHESIS OF RK-397 chapter 2 A FORMAL TOTAL SYNTHESIS OF THE MARINE DITERPENOID, DIISOCYANOADOCIANE chapter 3 TOTAL SYNTHESES OF ZOAPATANOL chapter 4 SYNTHESIS OF MOLECULAR TWEEZERS AND CLIPS BY THE USE OF A MOLECULAR LEGO SET AND THEIR SUPRAMOLECULAR FUNCTIONS chapter 5 APPLICATION OF C-GLYCOSIDES IN THE TOTAL SYNTHESIS OF (-)-GAMBIEROL chapter 6 A BIOMIMETIC APPROACH TO THE OCAGLAMIDES EMPLOYING PHOTOGENERATION OF OXIDOPYRYLIUMS DERIVED FROM 3-HYDROXYFLAVONES chapter 7 SYNTHESIS STUDIES OF DOLABELLANES AND TRANSANNULAR PROCESSES LEADING TO RELATED DITERPENES chapter 8 DIPHENYLOXAZINONES: VERSATILE TEMPLATES FOR THE ASYMMETRIC SYNTHESIS OF -AMINO ACIDS, PEPTIDE ISOSTERES, AND NATURAL PRODUCTS chapter 9 RHODIUM-CATALYZED CYCLOISOMERIZATION REACTIONS OF ALLENES IN DIVERSITY-ORIENTED SYNTHESIS chapter 10 HYDROGEN-BOND-MEDIATED ORGANIC SYNTHESIS IN THE SOLID STATE chapter 11 TOTAL SYNTHESES OF NATURAL PRODUCTS USING THE COMBINED CH ACTIVATION/COPE REARRANGEMENT AS THE KEY STEP chapter 12 THE TOTAL SYNTHESIS OF AMPHIBIAN ALKALOIDS USING THE INTRAMOLECULAR SCHMIDT REACTION chapter 13 SEDUCED BY A SIREN’S CALL: EXPANDING APPLICATIONS FOR AROMATIC COMPOUNDS AND THE SYNTHESIS OF (+)-RISHIRILIDE B
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- © Academic Press 2008
- 12th December 2007
- Academic Press
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Professor Michael Harmata graduated from the University of Illinois-Chicago with honors and highest distinction in chemistry. In 1980, he began graduate studies in chemistry at the University of Illinois-Champaign/Urbana where he was awarded a University Teaching Fellowship. He worked with Professor Scott E. Denmark on the invention of the carbanion-accelerated Claisen rearrangement. In his second year of study, he was awarded an Eastman Kodak Research Fellowship. Upon graduation in 1985, he was awarded an NIH postdoctoral fellowship which he used to study with Professor Paul A. Wender at Stanford University, where he worked on the synthesis of the neocarzinostatin chromophore. In 1986, Prof. Harmata began his independent career at the University of Missouri-Columbia. He became an Associate Professor in 1992 and a full professor in 1998. In 2000, he was named the Norman Rabjohn Distinguished Professor of Chemistry in recognition of his achievements in research and teaching. In 1998, he received a research fellowship from the Alexander von Humboldt Foundation and stayed for a year at the University of Göttingen where he was affiliated with the groups of Professors Reinhard Brückner and Lutz. F. Tietze. In 2000, he served as chair of the Gordon conference on Organic Reactions and Processes. In 2010, he was named the first Justus Liebig Professor of Chemistry at the Justus Liebig Üniversität in Giessen, Germany. In 2011, he was a JSPS fellow. He has been a visiting professor in Giessen and Strasbourg and has delivered over 180 invited lectures in the United States and Europe. He is a member of the American Chemical Society, Gesellschaft Deutscher Chemiker, International Society of Heterocyclic Chemistry, and the Alexander von Humboldt Association of America.
University of Missouri, MO, USA
@qu: "This book is a chronicle of synthetic problems and strategies written by leading organic chemists, who give their own personal accounts of the practice of organic synthesis. It is part lab. notes and memoir and should be an interesting read for both organic chemistry students and practitioners alike." @source: J. AM. CHEM. SOC, Vol. 128, no. 10, 2006