Store-Operated Calcium Channels

Store-Operated Calcium Channels

1st Edition - July 24, 2013

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  • Editor: Murali Prakriya
  • Hardcover ISBN: 9780124078703
  • eBook ISBN: 9780124079380

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Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful.

Key Features

  • The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels
  • Contributors are authoritative researchers who have produced important advances in the field
  • The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject


Scientists and researchers in biochemistry and molecular and cellular biology

Table of Contents

  • Chapter One. Store-Operated Orai Channels: Structure and Function

    1 Introduction

    2 Identification of the Orai Proteins

    3 STIM1 Is the ER Ca2 + Sensor for SOCE

    4 Orai1 Is the Pore-Forming Subunit of the CRAC Channel

    5 The CRAC Channel Is Essential for Lymphocyte Activation

    6 Oligomerization and Redistribution of STIM1 to the ER–Plasma Membrane Junctions

    7 Conformational Changes in STIM1

    8 STIM1 Directly Binds to Orai1

    9 Orai1 Domains Involved in STIM1 Binding

    10 CRAC Channel Subunit Stoichiometry

    11 How Many STIM Molecules Does It Take to Activate CRAC Channels?

    12 Structural Basis of Selectivity and Permeation

    13 STIM1 Regulates CRAC Channel Ion Selectivity

    14 Regulation of CRAC Channels by Calcium

    15 Conclusions



    Chapter Two. STIM–ORAI Interactions That Control the CRAC Channel

    1 Overview of STIM–ORAI Interactions

    2 The C-terminal Region of the ORAI Channel

    3 The N-terminal Region of the ORAI Channel

    4 Conclusion



    Chapter Three. Structure and Function of Endoplasmic Reticulum STIM Calcium Sensors

    1 Introduction

    2 STIM and Orai Domain Architectures

    3 STIM1 and Orai1 in the Activation in SOCE

    4 Human STIM1 and STIM2 EF–SAM Biophysical Features

    5 Human STIM1 EF–SAM Structure

    6 Human STIM2 EF–SAM Structure

    7 Human STIM1 and STIM2 Cytosolic Domains

    8 STIM Coupling to Orai

    9 Concluding Remarks



    Chapter Four. On the Stoichiometry of Resting and Activated CRAC Channels

    1 The Stoichiometry of Orai1

    2 The Stoichiometry of STIM1

    3 Summary



    Chapter Five. Alternative Forms of the Store-Operated Calcium Entry Mediators, STIM1 and Orai1

    1 Store-Operated Channels

    2 STIM1 Phosphorylation in Mitosis

    3 Two Forms of Orai1

    4 Summary and Remaining Questions



    Chapter Six. The ARC Channel—An Endogenous Store-Independent Orai Channel

    1 Introduction

    2 Store-Independent Calcium Entry and the Discovery of the ARC Channels

    3 Molecular Identity of the ARC Channel

    4 Molecular Basis of ARC Channel Activation

    5 Regulation of ARC Channel Activity

    6 What Do ARC Channels Do?

    7 Speculations and Conclusions



    Chapter Seven. Contribution and Regulation of TRPC Channels in Store-Operated Ca2 + Entry

    1 Introduction

    2 Physiological Functions of TRPC Channel-Mediated SOCE

    3 Characteristics of TRPC Channels

    4 TRPC1 Channel in SOCE

    5 Plasma Membrane Domains Involved in SOCE

    6 Distinct Physiological Functions of TRPC1 and Orai1

    7 Assembly and Function of TRPC/STIM1/Orai1 Microdomains

    8 Conclusion


    Chapter Eight. Molecular Regulation of the Pore Component of CRAC Channels, Orai1

    1 Introduction

    2 Current Understanding of CRAC Channel Activation and Inactivation

    3 Cytoplasmic Ca2 +-Sensitive Interactors of CRAC Channels—CaM and CRACR2A

    4 Negative Regulators of Orai1-Mediated SOCE

    5 Positive Regulators of Orai1-Mediated SOCE

    6 Adenylate Cyclase-Mediated Cross Talk Between cAMP and Ca2 + Signaling Pathway

    7 Orai Proteins and ARC Channels

    8 Posttranslational Modification of CRAC Channel Components

    9 Relationship Between Mitochondria and SOCE

    10 Conclusions



    Chapter Nine. Emerging Roles for Native Orai Ca2+ Channels in Cardiovascular Disease

    1 Introduction

    2 Orai Channels

    3 Orai Channels in the Heart

    4 Orai Channels in Vessels

    5 Conclusion and Perspective



    Chapter Ten. The Neglected CRAC Proteins: Orai2, Orai3, and STIM2

    1 Introduction

    2 STIM2

    3 Orai2

    4 Orai3

    5 Outlook and Open Questions




Product details

  • No. of pages: 298
  • Language: English
  • Copyright: © Academic Press 2013
  • Published: July 24, 2013
  • Imprint: Academic Press
  • Hardcover ISBN: 9780124078703
  • eBook ISBN: 9780124079380

About the Serial Volume Editor

Murali Prakriya

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