Stimuli-Responsive Nanocarriers

Stimuli-Responsive Nanocarriers

Recent Advances in Tailor-Made Therapeutics

1st Edition - January 4, 2022

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  • Editors: Virendra Gajbhiye, Kavita Gajbhiye, Seungpyo Hong
  • Paperback ISBN: 9780128244562
  • eBook ISBN: 9780323859042

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Stimuli-Responsive Nanocarriers: Recent Advances in Tailor-Made Therapeutics compiles dispersed knowledge into a complete and comprehensive source to help researchers understand and progress stimuli-responsive nanocarriers. The book contains recent advancements made in the field of stimuli-responsive nanocarriers with their application in controlled drug delivery against various diseases. It focuses on the design, mechanism, construction, therapeutic application and future challenges of stimuli-responsive nanocarriers which will help new researchers in designing next generation tailor-made advanced therapeutics.  Finally, the book covers future aspects and challenges present in the route of development of stimuli responsive nanocarriers for disease therapeutics. Various recent advances and biomedical applications assembled in this book will guide scientists on how to design and develop novel controlled drug release systems.

Key Features

  • Provides comprehensive knowledge of basic design, mechanism and construction of nanocarrier based stimuli-responsive drug releases
  • Explores various nanocarriers characteristically used in the development of stimuli-responsive drug release systems
  • Envisages future opportunities, challenges and implementation of nanocarrier based stimuli-responsive drug release systems in disease therapeutics


Pharmaceutical researchers and medical personnel involved in the development of advanced techniques and methods for diagnosis and treatment of various diseases. Postgraduate students will also find this useful. Biomedical professionals working in drug delivery

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • List of contributors
  • Preface
  • Chapter 1. An overview of stimuli-responsive nanocarriers: State of the art
  • Abstract
  • 1.1 Introduction
  • 1.2 Clinical translation of the stimuli-responsive nanocarriers
  • References
  • Chapter 2. Stimuli-responsive strategies: Role of various molecules/moieties facilitating the design of stimuli-responsive nanocarriers
  • Abstract
  • 2.1 Introduction
  • 2.2 Enzyme-responsive nanocarriers
  • 2.3 pH-responsive
  • 2.4 Temperature-responsive
  • 2.5 Light-responsive
  • 2.6 Redox-responsive
  • 2.7 Glucose-responsive
  • 2.8 Conclusion
  • References
  • Chapter 3. Vesicular nanocarrier based stimuli-responsive drug delivery systems
  • Abstract
  • 3.1 Introduction
  • 3.2 Endogenous stimuli-responsive nanovesicles
  • 3.3 Exogenous stimuli-responsive nanovesicles
  • 3.4 Current clinical status and outlook
  • References
  • Chapter 4. Stimuli-responsive polymeric nanoparticles as controlled drug delivery systems
  • Abstract
  • 4.1 Introduction
  • 4.2 Development of stimuli-responsive polymeric nanocarriers
  • 4.3 Physicochemical properties of stimuli-responsive polymeric nanocarriers
  • 4.4 Stimuli-responsive drug delivery nanocarriers
  • 4.5 Obstacles and challenges
  • 4.6 Conclusion and perspectives
  • Acknowledgments
  • References
  • Chapter 5. Dendrimers and dendritic nanoparticles for stimuli-responsive nanomedicine
  • Abstract
  • 5.1 Introduction
  • 5.2 Dendrimers and dendritic nanoparticles as nanomedicine platforms
  • 5.3 Improved tumor penetration of stimuli-responsive nanomedicines with dendrimers
  • 5.4 Cytoplasmic drug release from stimuli-responsive nanomedicines with dendrimers
  • 5.5 Enhanced lysosomal escape from stimuli-responsive nanomedicines with dendrimers
  • 5.6 Localized drug release from dendritic nanomedicines in response to electromagnetic stimulation
  • 5.7 Conclusions
  • References
  • Chapter 6. Stimuli-responsive polymer-coated iron oxide nanoparticles as drug delivery platforms
  • Abstract
  • 6.1 Introduction
  • 6.2 Synthesis of magnetic iron oxide nanoparticles
  • 6.3 Synthesis of polymer-coated magnetic nanoparticles
  • 6.4 Stimuli-responsive polymer-coated iron oxide nanoparticles
  • 6.5 Conclusions
  • References
  • Chapter 7. Stimuli-responsive drug delivery systems for cancer immunotherapy
  • Abstract
  • 7.1 Introduction
  • 7.2 Stimuli for tumor-responsive drug delivery systems
  • 7.3 Application of stimuli-responsive drug delivery systems in cancer immunotherapy
  • 7.4 Conclusion and outlook
  • Conflict of interest
  • Acknowledgments
  • References
  • Chapter 8. Quantum dots based vehicles for controlled drug release in conjunction with bio-imaging
  • Abstract
  • 8.1 Introduction
  • 8.2 General properties of quantum dots
  • 8.3 Synthesis and characterization of quantum dots
  • 8.4 Toxicology of quantum dots
  • 8.5 Stimuli-responsive quantum dots for drug delivery and bio-imaging
  • 8.6 Stimuli-responsive quantum dots for bio-imaging
  • 8.7 Clinical status of quantum dots
  • 8.8 Challenges and prospects
  • 8.9 Conclusion
  • Acknowledgment
  • References
  • Chapter 9. Mesoporous silica nanoparticles-based stimuli-triggered drug release systems
  • Abstract
  • 9.1 Introduction
  • 9.2 Internal stimuli-responsive MSNPs
  • 9.3 External stimuli-responsive MSNPs
  • 9.4 Multiple trigger-responsive MSNPs
  • 9.5 Conclusion and future perspectives
  • References
  • Chapter 10. Solid–lipid nanoparticles based vehicles for stimuli inspired delivery of bioactives
  • Abstract
  • 10.1 Introduction
  • 10.2 Journey
  • 10.3 Stimuli-responsive SLNs
  • 10.4 Conclusion and future perspectives
  • References
  • Chapter 11. Tailored gold nanoparticles for improved control over drug release
  • Abstract
  • 11.1 Introduction
  • 11.2 Properties of AuNPs
  • 11.3 Stimuli-responsive AuNPs and its applications in cancer therapy and bioimaging
  • 11.4 Application of stimuli-responsive AuNPs in other diseases
  • 11.5 Conclusion
  • References
  • Chapter 12. Lipid–polymer hybrid nanoparticles as a smart drug delivery platform
  • Abstract
  • 12.1 Introduction
  • 12.2 Types of lipid–polymer hybrid nanoparticles
  • 12.3 Merits and mechanisms of hybrid formation
  • 12.4 Methods of lipid–polymer hybrid nanoparticle preparation
  • 12.5 Stimuli-responsive lipid–polymer hybrid nanoparticles in drug delivery applications
  • 12.6 Endogenous stimuli-responsive lipid–polymer hybrid nanoparticles
  • 12.7 Exogenous stimuli-responsive lipid–polymer hybrid nanoparticles
  • 12.8 Clinical studies
  • 12.9 Future perspective and challenges
  • 12.10 Conclusions
  • Acknowledgments
  • References
  • Chapter 13. Polymersomes as a promising vehicle for controlled drug delivery
  • Abstract
  • 13.1 Introduction
  • 13.2 Polymersomes responsive to physical and chemical stimuli
  • 13.3 Chemical stimuli-responsive polymersome
  • 13.4 Physical stimuli-responsive polymersome
  • 13.5 Conclusion
  • References
  • Chapter 14. Carbon nanomaterial-based stimuli-responsive drug delivery strategies
  • Abstract
  • 14.1 Introduction
  • 14.2 pH-responsive carbon-based nanomaterials
  • 14.3 Light-responsive carbon-based nanomaterials
  • 14.4 Redox-responsive carbon-based nanomaterials
  • 14.5 Temperature-responsive carbon-based nanomaterials
  • 14.6 Enzyme-responsive carbon-based nanomaterials
  • 14.7 Multiple-responsive carbon-based nanomaterials
  • 14.8 Electro-responsive carbon-based nanomaterials
  • 14.9 Conclusion and future perspectives
  • References
  • Chapter 15. Protein nanocapsules as a smart drug delivery platform
  • Abstract
  • 15.1 Introduction
  • 15.2 Stimuli-responsive, protein-based nanocapsules
  • 15.3 Applications of stimuli-responsive, protein-based nanocapsules in the treatment of different carcinomas
  • 15.4 Challenges and future prospects
  • 15.5 Conclusion
  • References
  • Chapter 16. Copper nanoparticles-based stimuli-responsive approaches
  • Abstract
  • 16.1 Introduction
  • 16.2 Conclusion
  • References
  • Chapter 17. Stimuli-responsive nanogels as promising carriers for controlled delivery of anticancer therapeutics
  • Abstract
  • 17.1 Introduction
  • 17.2 Nanogels with endogenous trigger-responsive behavior and their biomedical application in cancer therapy
  • 17.3 Summary and perspectives
  • Acknowledgments
  • References
  • Index

Product details

  • No. of pages: 484
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: January 4, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780128244562
  • eBook ISBN: 9780323859042

About the Editors

Virendra Gajbhiye

Dr. Virendra Gajbhiye has been working in the field of nanomedicine for the last 15 years. He has a doctoral degree (Ph.D.) in Pharmaceutical Science with post-doctoral research experience at University of Wisconsin-Madison and Oregon Health and Sciences University. Since 2013 he is working as a Scientist in Nanomedicine at Agharkar Research Institute, Pune, India. He has worked extensively with polymeric nanoparticles specially dendrimers and mesoporous silica nanoparticles. His research interest lies in Nanomedicine, Targeted drug and siRNA delivery, Biomedical application of dendrimers, Biomaterials unimolecular micelles and imaging, Multifunctional polymeric nanoparticles, Nanoparticles in tissue engineering.

Affiliations and Expertise

Scientist in Nanomedicine, Agharkar Research Institute, Pune, India

Kavita Gajbhiye

Dr. Kavita Gajbhiye has been working in the field of nanomedicine for the last 15 years. She completed her M. Pharm and Ph.D. at Dr. H. S. Gour University, Sagar, MP, India. She has worked as SERB National Post-doctoral Fellow at CSIR-National Chemical Laboratory, Pune, India for two years. The major focus of her research is the synthesis and evaluation of dibolock and triblock polymer based nanoconstructs intended for drug delivery and other biomedical applications. She is presently working as Assistant Professor at Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune, India. Furthermore, as a principal investigator, she has received research grant from SERB, Govt. of India.

Affiliations and Expertise

Assistant Professor, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune, India

Seungpyo Hong

Prof. Seungpyo Hong is Professor of Pharmaceutics in the Pharmaceutical Sciences Division, School of Pharmacy at the University of Wisconsin-Madison (USA). He serves as Associate Editor for Nanomedicine: Nanotechnology, Biology and Medicine (Elsevier). He graduated from Hanyang University, Seoul, Korea with BS and MS degrees in polymer engineering. He started his PhD study in Macromolecular Science and Engineering at the University of Michigan. After, he joined Massachusetts Institute of Technology (MIT) as a postdoctoral associate in the laboratory of Prof. Robert Langer. From 2008 to 2014, Seungpyo was Assistant Professor in the College of Pharmacy at the University of Illinois at Chicago (UIC) where he was promoted to Associate Professor with tenure in 2014, and subsequently joined the UW-Madison faculty as full Professor in 2016. Since 2008, he has led a research group under the major research theme of “Biomimetic Nanotechnology” for cancer diagnosis and treatment.

Affiliations and Expertise

Professor of Pharmaceutics, Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, USA

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