Stimuli-Responsive Nanocarriers

Recent Advances in Tailor-Made Therapeutics

1st Edition - January 4, 2022
Editors: Virendra Gajbhiye, Kavita Gajbhiye, Seungpyo Hong
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 4 4 5 6 - 2
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 9 0 4 - 2

Stimuli-Responsive Nanocarriers: Recent Advances in Tailor-Made Therapeutics compiles dispersed knowledge into a complete and comprehensive source to help researchers understan… Read more

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Stimuli-Responsive Nanocarriers: Recent Advances in Tailor-Made Therapeutics compiles dispersed knowledge into a complete and comprehensive source to help researchers understand and progress stimuli-responsive nanocarriers. The book contains recent advancements made in the field of stimuli-responsive nanocarriers with their application in controlled drug delivery against various diseases. It focuses on the design, mechanism, construction, therapeutic application and future challenges of stimuli-responsive nanocarriers which will help new researchers in designing next generation tailor-made advanced therapeutics. Finally, the book covers future aspects and challenges present in the route of development of stimuli responsive nanocarriers for disease therapeutics.

Various recent advances and biomedical applications assembled in this book will guide scientists on how to design and develop novel controlled drug release systems.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Preface
Chapter 1. An overview of stimuli-responsive nanocarriers: State of the art
Abstract
1.1 Introduction
1.2 Clinical translation of the stimuli-responsive nanocarriers
References
Chapter 2. Stimuli-responsive strategies: Role of various molecules/moieties facilitating the design of stimuli-responsive nanocarriers
Abstract
2.1 Introduction
2.2 Enzyme-responsive nanocarriers
2.3 pH-responsive
2.4 Temperature-responsive
2.5 Light-responsive
2.6 Redox-responsive
2.7 Glucose-responsive
2.8 Conclusion
References
Chapter 3. Vesicular nanocarrier based stimuli-responsive drug delivery systems
Abstract
3.1 Introduction
3.2 Endogenous stimuli-responsive nanovesicles
3.3 Exogenous stimuli-responsive nanovesicles
3.4 Current clinical status and outlook
References
Chapter 4. Stimuli-responsive polymeric nanoparticles as controlled drug delivery systems
Abstract
4.1 Introduction
4.2 Development of stimuli-responsive polymeric nanocarriers
4.3 Physicochemical properties of stimuli-responsive polymeric nanocarriers
4.4 Stimuli-responsive drug delivery nanocarriers
4.5 Obstacles and challenges
4.6 Conclusion and perspectives
Acknowledgments
References
Chapter 5. Dendrimers and dendritic nanoparticles for stimuli-responsive nanomedicine
Abstract
5.1 Introduction
5.2 Dendrimers and dendritic nanoparticles as nanomedicine platforms
5.3 Improved tumor penetration of stimuli-responsive nanomedicines with dendrimers
5.4 Cytoplasmic drug release from stimuli-responsive nanomedicines with dendrimers
5.5 Enhanced lysosomal escape from stimuli-responsive nanomedicines with dendrimers
5.6 Localized drug release from dendritic nanomedicines in response to electromagnetic stimulation
5.7 Conclusions
References
Chapter 6. Stimuli-responsive polymer-coated iron oxide nanoparticles as drug delivery platforms
Abstract
6.1 Introduction
6.2 Synthesis of magnetic iron oxide nanoparticles
6.3 Synthesis of polymer-coated magnetic nanoparticles
6.4 Stimuli-responsive polymer-coated iron oxide nanoparticles
6.5 Conclusions
References
Chapter 7. Stimuli-responsive drug delivery systems for cancer immunotherapy
Abstract
7.1 Introduction
7.2 Stimuli for tumor-responsive drug delivery systems
7.3 Application of stimuli-responsive drug delivery systems in cancer immunotherapy
7.4 Conclusion and outlook
Conflict of interest
Acknowledgments
References
Chapter 8. Quantum dots based vehicles for controlled drug release in conjunction with bio-imaging
Abstract
8.1 Introduction
8.2 General properties of quantum dots
8.3 Synthesis and characterization of quantum dots
8.4 Toxicology of quantum dots
8.5 Stimuli-responsive quantum dots for drug delivery and bio-imaging
8.6 Stimuli-responsive quantum dots for bio-imaging
8.7 Clinical status of quantum dots
8.8 Challenges and prospects
8.9 Conclusion
Acknowledgment
References
Chapter 9. Mesoporous silica nanoparticles-based stimuli-triggered drug release systems
Abstract
9.1 Introduction
9.2 Internal stimuli-responsive MSNPs
9.3 External stimuli-responsive MSNPs
9.4 Multiple trigger-responsive MSNPs
9.5 Conclusion and future perspectives
References
Chapter 10. Solid–lipid nanoparticles based vehicles for stimuli inspired delivery of bioactives
Abstract
10.1 Introduction
10.2 Journey
10.3 Stimuli-responsive SLNs
10.4 Conclusion and future perspectives
References
Chapter 11. Tailored gold nanoparticles for improved control over drug release
Abstract
11.1 Introduction
11.2 Properties of AuNPs
11.3 Stimuli-responsive AuNPs and its applications in cancer therapy and bioimaging
11.4 Application of stimuli-responsive AuNPs in other diseases
11.5 Conclusion
References
Chapter 12. Lipid–polymer hybrid nanoparticles as a smart drug delivery platform
Abstract
12.1 Introduction
12.2 Types of lipid–polymer hybrid nanoparticles
12.3 Merits and mechanisms of hybrid formation
12.4 Methods of lipid–polymer hybrid nanoparticle preparation
12.5 Stimuli-responsive lipid–polymer hybrid nanoparticles in drug delivery applications
12.6 Endogenous stimuli-responsive lipid–polymer hybrid nanoparticles
12.7 Exogenous stimuli-responsive lipid–polymer hybrid nanoparticles
12.8 Clinical studies
12.9 Future perspective and challenges
12.10 Conclusions
Acknowledgments
References
Chapter 13. Polymersomes as a promising vehicle for controlled drug delivery
Abstract
13.1 Introduction
13.2 Polymersomes responsive to physical and chemical stimuli
13.3 Chemical stimuli-responsive polymersome
13.4 Physical stimuli-responsive polymersome
13.5 Conclusion
References
Chapter 14. Carbon nanomaterial-based stimuli-responsive drug delivery strategies
Abstract
14.1 Introduction
14.2 pH-responsive carbon-based nanomaterials
14.3 Light-responsive carbon-based nanomaterials
14.4 Redox-responsive carbon-based nanomaterials
14.5 Temperature-responsive carbon-based nanomaterials
14.6 Enzyme-responsive carbon-based nanomaterials
14.7 Multiple-responsive carbon-based nanomaterials
14.8 Electro-responsive carbon-based nanomaterials
14.9 Conclusion and future perspectives
References
Chapter 15. Protein nanocapsules as a smart drug delivery platform
Abstract
15.1 Introduction
15.2 Stimuli-responsive, protein-based nanocapsules
15.3 Applications of stimuli-responsive, protein-based nanocapsules in the treatment of different carcinomas
15.4 Challenges and future prospects
15.5 Conclusion
References
Chapter 16. Copper nanoparticles-based stimuli-responsive approaches
Abstract
16.1 Introduction
16.2 Conclusion
References
Chapter 17. Stimuli-responsive nanogels as promising carriers for controlled delivery of anticancer therapeutics
Abstract
17.1 Introduction
17.2 Nanogels with endogenous trigger-responsive behavior and their biomedical application in cancer therapy
17.3 Summary and perspectives
Acknowledgments
References
Index

Virendra Gajbhiye

Dr. Virendra Gajbhiye has been working in the field of nanomedicine for the last 15 years. He has a doctoral degree (Ph.D.) in Pharmaceutical Science with post-doctoral research experience at University of Wisconsin-Madison and Oregon Health and Sciences University. Since 2013 he is working as a Scientist in Nanomedicine at Agharkar Research Institute, Pune, India. He has worked extensively with polymeric nanoparticles specially dendrimers and mesoporous silica nanoparticles. His research interest lies in Nanomedicine, Targeted drug and siRNA delivery, Biomedical application of dendrimers, Biomaterials unimolecular micelles and imaging, Multifunctional polymeric nanoparticles, Nanoparticles in tissue engineering.

Affiliations and expertise

Scientist in Nanomedicine, Agharkar Research Institute, Pune, India

Kavita Gajbhiye

Dr. Kavita Gajbhiye has been working in the field of nanomedicine for the last 15 years. She completed her M. Pharm and Ph.D. at Dr. H. S. Gour University, Sagar, MP, India. She has worked as SERB National Post-doctoral Fellow at CSIR-National Chemical Laboratory, Pune, India for two years. The major focus of her research is the synthesis and evaluation of dibolock and triblock polymer based nanoconstructs intended for drug delivery and other biomedical applications. She is presently working as Assistant Professor at Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune, India. Furthermore, as a principal investigator, she has received research grant from SERB, Govt. of India.

Affiliations and expertise

Assistant Professor, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune, India

Seungpyo Hong

Prof. Seungpyo Hong is Professor of Pharmaceutics in the Pharmaceutical Sciences Division, School of Pharmacy at the University of Wisconsin-Madison (USA). He serves as Associate Editor for Nanomedicine: Nanotechnology, Biology and Medicine (Elsevier). He graduated from Hanyang University, Seoul, Korea with BS and MS degrees in polymer engineering. He started his PhD study in Macromolecular Science and Engineering at the University of Michigan. After, he joined Massachusetts Institute of Technology (MIT) as a postdoctoral associate in the laboratory of Prof. Robert Langer. From 2008 to 2014, Seungpyo was Assistant Professor in the College of Pharmacy at the University of Illinois at Chicago (UIC) where he was promoted to Associate Professor with tenure in 2014, and subsequently joined the UW-Madison faculty as full Professor in 2016. Since 2008, he has led a research group under the major research theme of “Biomimetic Nanotechnology” for cancer diagnosis and treatment.

Affiliations and expertise

Professor of Pharmaceutics, Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, USA