Steroidal Activity in Experimental Animals and Man

Steroidal Activity in Experimental Animals and Man

1st Edition - January 1, 1964

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  • Editor: Ralph I. Dorfman
  • eBook ISBN: 9781483272993

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Description

Methods in Hormone Research, Volume III: Steroidal Activity in Experimental Animals and Man, Part A focuses on protection against irradiation damage, anti-mammary tumor activity, body lipids, anti-aldosterone, central depressant action, and copulatory reflex activity. The selection first offers information on estrogens and anti-estrogens, including relative potencies in vaginal smear tests, vaginal tests, and uterine weight tests, mechanism of estrogen action, and mode action of anti-estrogens. The book then examines irradiation protection and anti-mammary tumor activities in rats and mice. The publication surveys steroids and lipid metabolism and the activities of adrenocorticosteroids in experimental animals and man. Discussions focus on adrenocortical, estrogenic, and androgenic and anabolic steroids; relative activities of corticosteroids assessed by laboratory and clinical methodology; and comparative efficacies of corticosteroids. The manuscript then ponders on anti-aldosterones, steroid central depressants, and copulatory reflex response to steroids. The selection is a vital source of data for readers interested in steroidal activity in man and animals.

Table of Contents


  • Contents

    Contributors to Volume III

    Preface

    Contents of Volumes I, II, and IV

    1. Estrogens

    I. Types of Estrogen

    II. Relative Potencies in Vaginal Smear Tests

    III. Relative Potencies in Other Vaginal Tests

    IV. Relative Potencies in Uterine Weight Tests

    V. Relative Potencies in Other Tests

    VI. Relative Potencies in Man

    VII. Interruption of Early Pregnancy

    VIII. Investigations in Vitro

    IX. Mechanism of Estrogen Action

    References

    2. Anti-Estrogens

    I. Types of Anti-Estrogens

    II. Relative Potencies in Vaginal Smear Tests

    III. Relative Potencies in Other Vaginal Tests

    IV. Relative Potencies in Uterine Weight Tests

    V. In Vitro Tests

    VI. Other Activities

    VII. Mode of Action of Anti-Estrogens

    References

    3. Irradiation Protection

    I. Introduction

    II. Corticoids

    III. Estrogens

    IV. Androgens

    V. Progestational Steroids

    VI. Summary

    References

    4. Anti-Mammary Tumor Activities in Rats and Mice

    I. Introduction

    II. Steroids Showing Activity Against Mouse Mammary Tumors

    III. Steroids Showing Activity Against Rat Mammary Tumors

    IV. Activity of Steroids Against a Spectrum of Rat and Mouse Mammary Tumors

    References

    5. Steroids and Lipid Metabolism

    I. Introduction

    II. Adrenocortical Steroids

    III. Estrogenic Steroids

    IV. Androgenic and Anabolic Steroids

    V. Progestational Steroids

    VI. Steroid Inhibitors of Cholesterol Biosynthesis

    References

    6. Activities of Adrenocorticosteroids in Experimental Animals and Man

    I. Introduction

    II. Relative Activities of Corticosteroids Assessed by Laboratory and Clinical Methodology

    III. Comparative Efficacies of Corticosteroids

    IV. Structure-Activity Relationships

    References

    7. Anti-Aldosterones

    I. Introduction

    II. Steroidal Spirolactones

    III. Progesterone and Derivatives

    IV. Testosterone and Derivatives

    V. Corticoids

    VI. Estrogenic Steroids

    References

    8. Steroid Central Depressants

    I. Introduction

    II. Relationship of Steroid Structure to Anesthetic Activity

    III. Pharmacology of Hydroxydione

    References

    9. Copulatory Reflex Response to Steroids

    I. Introduction

    II. Response to Progestational Compounds

    III. Response to Nonprogestational Steroids

    IV. Relation Between Copulatory Reflex Activity and Progestational Activity

    V. Summary

    References

    Author Index

    Subject Index

Product details

  • No. of pages: 544
  • Language: English
  • Copyright: © Academic Press 1964
  • Published: January 1, 1964
  • Imprint: Academic Press
  • eBook ISBN: 9781483272993

About the Editor

Ralph I. Dorfman

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