Steroidal Activity in Experimental Animals and Man

1st Edition - January 1, 1964
Editor: Ralph I. Dorfman
Language: English
eBook ISBN:
9 7 8 - 1 - 4 8 3 2 - 7 2 9 9 - 3

Methods in Hormone Research, Volume III: Steroidal Activity in Experimental Animals and Man, Part A focuses on protection against irradiation damage, anti-mammary tumor activity,… Read more

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Methods in Hormone Research, Volume III: Steroidal Activity in Experimental Animals and Man, Part A focuses on protection against irradiation damage, anti-mammary tumor activity, body lipids, anti-aldosterone, central depressant action, and copulatory reflex activity. The selection first offers information on estrogens and anti-estrogens, including relative potencies in vaginal smear tests, vaginal tests, and uterine weight tests, mechanism of estrogen action, and mode action of anti-estrogens. The book then examines irradiation protection and anti-mammary tumor activities in rats and mice. The publication surveys steroids and lipid metabolism and the activities of adrenocorticosteroids in experimental animals and man. Discussions focus on adrenocortical, estrogenic, and androgenic and anabolic steroids; relative activities of corticosteroids assessed by laboratory and clinical methodology; and comparative efficacies of corticosteroids. The manuscript then ponders on anti-aldosterones, steroid central depressants, and copulatory reflex response to steroids. The selection is a vital source of data for readers interested in steroidal activity in man and animals.

Contents

Contributors to Volume III

Preface

Contents of Volumes I, II, and IV

1. Estrogens

I. Types of Estrogen

II. Relative Potencies in Vaginal Smear Tests

III. Relative Potencies in Other Vaginal Tests

IV. Relative Potencies in Uterine Weight Tests

V. Relative Potencies in Other Tests

VI. Relative Potencies in Man

VII. Interruption of Early Pregnancy

VIII. Investigations in Vitro

IX. Mechanism of Estrogen Action

References

2. Anti-Estrogens

I. Types of Anti-Estrogens

II. Relative Potencies in Vaginal Smear Tests

III. Relative Potencies in Other Vaginal Tests

IV. Relative Potencies in Uterine Weight Tests

V. In Vitro Tests

VI. Other Activities

VII. Mode of Action of Anti-Estrogens

References

3. Irradiation Protection

I. Introduction

II. Corticoids

III. Estrogens

IV. Androgens

V. Progestational Steroids

VI. Summary

References

4. Anti-Mammary Tumor Activities in Rats and Mice

I. Introduction

II. Steroids Showing Activity Against Mouse Mammary Tumors

III. Steroids Showing Activity Against Rat Mammary Tumors

IV. Activity of Steroids Against a Spectrum of Rat and Mouse Mammary Tumors

References

5. Steroids and Lipid Metabolism

I. Introduction

II. Adrenocortical Steroids

III. Estrogenic Steroids

IV. Androgenic and Anabolic Steroids

V. Progestational Steroids

VI. Steroid Inhibitors of Cholesterol Biosynthesis

References

6. Activities of Adrenocorticosteroids in Experimental Animals and Man

I. Introduction

II. Relative Activities of Corticosteroids Assessed by Laboratory and Clinical Methodology

III. Comparative Efficacies of Corticosteroids

IV. Structure-Activity Relationships

References

7. Anti-Aldosterones

I. Introduction

II. Steroidal Spirolactones

III. Progesterone and Derivatives

IV. Testosterone and Derivatives

V. Corticoids

VI. Estrogenic Steroids

References

8. Steroid Central Depressants

I. Introduction

II. Relationship of Steroid Structure to Anesthetic Activity

III. Pharmacology of Hydroxydione

References

9. Copulatory Reflex Response to Steroids

I. Introduction

II. Response to Progestational Compounds

III. Response to Nonprogestational Steroids

IV. Relation Between Copulatory Reflex Activity and Progestational Activity

V. Summary

References

Author Index

Subject Index