Steroid Hormone Regulation of the Brain

Steroid Hormone Regulation of the Brain

Proceedings of an International Symposium Held at the Wenner-Gren Center, Stockholm, 27-28 October 1980

1st Edition - January 1, 1981

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  • Editors: Kjell Fuxe, Jan-Åke Gustafsson, Lennart Wetterberg
  • eBook ISBN: 9781483158679

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Steroid Hormone Regulation of the Brain focuses on the advancement of knowledge of the properties of brain steroid receptors and steroid target nerve cells, including the actions of gonadal steroids, adrenocortical steroids, and androgenic steroids on the brain. The selection features the work of authors who have inspiringly conducted extensive studies on the action of steroid hormones. The book starts with discussions that point out that steroid hormones not only function through intracellular steroid receptors, but possibly through steroid membrane actions as well. Studies to support this claim are presented. As to the action of steroid hormones on presynaptic transmitter mechanisms, the book suggests that adrenocortical and gonadal steroids can create alterations in noradrenaline, adrenaline, and dopamine levels and turnover within the hypothalamus and preoptic area. The effects of catecholestrogens on the brain are also elaborated. A contribution to this paper stresses that estrogens have antidopaminergic action in the extrapyramidal system. This idea is identified through a series of behavioral experiments and measurements of the levels of striatal acetylcholine. This selection is recommended to scientists interested in studying the effect of hormones on the brain.

Table of Contents

  • List of Participants

    Opening Address

    Section I Actions of Steroid Hormones

    Steroid Hormones in the Brain: Several Mechanisms?

    The Interaction of Estrogens with Intracellular Receptors and with Putative Neurotransmitter Receptors: Implications for the Mechanism of Activation of Sexual Behavior and Ovulation

    Studies on the Glucocorticoid Receptor

    Steroid Hormone Sites of Action in the Brain

    Developmental Aspects of Catecholestrogen Synthesis

    Regulation of Hepatic Steroid Metabolism by the Hypothalamo-Pituitary-Liver Axis

    Section II The Effects of Steroids on Presynaptic Transmitter Mechanisms

    Effects of Estrogen and Combined Treatment with Estrogen and Progesterone on Central Dopamine, Noradrenaline and Adrenaline Nerve Terminal Systems of the Ovariectomized Rat. Relationship of Changes in Amine Turnover to Changes in LH and Prolactin Secretion and in Sexual Behavior

    Acute Effects of Catecholestrogens on Hypothalamic and Median Eminence Catecholamines and Anterior Pituitary Gland Luteinizing Hormone and Prolactin Secretion in the Ovariectomized Rat

    Catecholestrogens in the Brain: Action on Pituitary Hormone Secretion and Catecholamine Turnover

    Effects of Androgenic and Adrenocortical Steroids on Hypothalamic and Preoptic Catecholamine Nerve Terminals and on the Secretion of Anterior Pituitary Hormones

    Modulatory Actions of Estradiol on Catecholamine and GABA Turnover and Effects on Serum Prolactin and LH Release

    Plasma Steroid—Tissue Catecholamine Relationships in Limbic and Related Areas of the Brain

    Steroids and Neurotransmitter Mechanisms in the Prenatal Period

    Section III Overview Lecture

    Electrophysiological Effects of Adrenocortical Hormones on the Brain

    Changes in the Firing Rate of Single Preoptic-Septical Neurons Induced by Direct Application of Natural and Conjugated Steroids

    Section IV Effects of Steroids on Transmitter Reception Mechanisms

    Effect of Steroid Hormones on the Level of Protein I in Rat Brain

    Biochemical Effects of Estrogens and Thyroid Hormones in the CNS

    Effects of Estrogen and Progesterone on Central α- and ß-Adrenergic Receptors in Ovariectorrized Rats: Evidence for Gonadal Steroid Receptor Regulation of Brain α- and ß-Adrenergic Receptors

    Gonadal Steroid Modification of Adrenergic and Opiate Receptor Binding in the Central Nervous System

    1α,25-(OH)2D3 Receptors in the Pituitary: Characterization and Relation to Dopaminergic Mechanisms

    Section V Steroid Hormonal Control of Behavior

    Sex Steroid Hormones and Sexual Behavior

    Progesterone, Monoamines and Sexual Behavior

    Neuroendocrine Control of Daily Rhythms in Rat Reproductive Behavior

    Hormones and Sexual Behavior in Rhesus and Talapoin Monkeys

    Behavioral and Biochemical Evidence of an Effect of Estradiol on Striatal Dopamine Receptors

    Estrogens and Striatal Cholinergic Function

    Glucocorticoids, Catecholamines and Avoidance Learning

    Modulation of 3H-Dihydroalprenolol Binding in the Hippocampus by Corticosterone

    Section VI Clinical Session

    Hypothalamo-Pituitary-Gonadal Function in Primary Endogenously Depressed Men: Preliminary Findings

    Pineal-Hypothalamic-Pituitary Function in Patients with Depressive Illness

    Subject Index

Product details

  • No. of pages: 424
  • Language: English
  • Copyright: © Pergamon 1981
  • Published: January 1, 1981
  • Imprint: Pergamon
  • eBook ISBN: 9781483158679

About the Editors

Kjell Fuxe

Affiliations and Expertise

Department of Histology, Karolinska Institutet

Jan-Åke Gustafsson

Lennart Wetterberg

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