Steroid Hormone Regulation of the Brain - 1st Edition - ISBN: 9780080268644, 9781483158679

Steroid Hormone Regulation of the Brain

1st Edition

Proceedings of an International Symposium Held at the Wenner-Gren Center, Stockholm, 27-28 October 1980

Editors: Kjell Fuxe Jan-Åke Gustafsson Lennart Wetterberg
eBook ISBN: 9781483158679
Imprint: Pergamon
Published Date: 1st January 1981
Page Count: 424
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Steroid Hormone Regulation of the Brain focuses on the advancement of knowledge of the properties of brain steroid receptors and steroid target nerve cells, including the actions of gonadal steroids, adrenocortical steroids, and androgenic steroids on the brain. The selection features the work of authors who have inspiringly conducted extensive studies on the action of steroid hormones. The book starts with discussions that point out that steroid hormones not only function through intracellular steroid receptors, but possibly through steroid membrane actions as well. Studies to support this claim are presented. As to the action of steroid hormones on presynaptic transmitter mechanisms, the book suggests that adrenocortical and gonadal steroids can create alterations in noradrenaline, adrenaline, and dopamine levels and turnover within the hypothalamus and preoptic area. The effects of catecholestrogens on the brain are also elaborated. A contribution to this paper stresses that estrogens have antidopaminergic action in the extrapyramidal system. This idea is identified through a series of behavioral experiments and measurements of the levels of striatal acetylcholine. This selection is recommended to scientists interested in studying the effect of hormones on the brain.

Table of Contents

List of Participants

Opening Address

Section I Actions of Steroid Hormones

Steroid Hormones in the Brain: Several Mechanisms?

The Interaction of Estrogens with Intracellular Receptors and with Putative Neurotransmitter Receptors: Implications for the Mechanism of Activation of Sexual Behavior and Ovulation

Studies on the Glucocorticoid Receptor

Steroid Hormone Sites of Action in the Brain

Developmental Aspects of Catecholestrogen Synthesis

Regulation of Hepatic Steroid Metabolism by the Hypothalamo-Pituitary-Liver Axis

Section II The Effects of Steroids on Presynaptic Transmitter Mechanisms

Effects of Estrogen and Combined Treatment with Estrogen and Progesterone on Central Dopamine, Noradrenaline and Adrenaline Nerve Terminal Systems of the Ovariectomized Rat. Relationship of Changes in Amine Turnover to Changes in LH and Prolactin Secretion and in Sexual Behavior

Acute Effects of Catecholestrogens on Hypothalamic and Median Eminence Catecholamines and Anterior Pituitary Gland Luteinizing Hormone and Prolactin Secretion in the Ovariectomized Rat

Catecholestrogens in the Brain: Action on Pituitary Hormone Secretion and Catecholamine Turnover

Effects of Androgenic and Adrenocortical Steroids on Hypothalamic and Preoptic Catecholamine Nerve Terminals and on the Secretion of Anterior Pituitary Hormones

Modulatory Actions of Estradiol on Catecholamine and GABA Turnover and Effects on Serum Prolactin and LH Release

Plasma Steroid—Tissue Catecholamine Relationships in Limbic and Related Areas of the Brain

Steroids and Neurotransmitter Mechanisms in the Prenatal Period

Section III Overview Lecture

Electrophysiological Effects of Adrenocortical Hormones on the Brain

Changes in the Firing Rate of Single Preoptic-Septical Neurons Induced by Direct Application of Natural and Conjugated Steroids

Section IV Effects of Steroids on Transmitter Reception Mechanisms

Effect of Steroid Hormones on the Level of Protein I in Rat Brain

Biochemical Effects of Estrogens and Thyroid Hormones in the CNS

Effects of Estrogen and Progesterone on Central α- and ß-Adrenergic Receptors in Ovariectorrized Rats: Evidence for Gonadal Steroid Receptor Regulation of Brain α- and ß-Adrenergic Receptors

Gonadal Steroid Modification of Adrenergic and Opiate Receptor Binding in the Central Nervous System

1α,25-(OH)2D3 Receptors in the Pituitary: Characterization and Relation to Dopaminergic Mechanisms

Section V Steroid Hormonal Control of Behavior

Sex Steroid Hormones and Sexual Behavior

Progesterone, Monoamines and Sexual Behavior

Neuroendocrine Control of Daily Rhythms in Rat Reproductive Behavior

Hormones and Sexual Behavior in Rhesus and Talapoin Monkeys

Behavioral and Biochemical Evidence of an Effect of Estradiol on Striatal Dopamine Receptors

Estrogens and Striatal Cholinergic Function

Glucocorticoids, Catecholamines and Avoidance Learning

Modulation of 3H-Dihydroalprenolol Binding in the Hippocampus by Corticosterone

Section VI Clinical Session

Hypothalamo-Pituitary-Gonadal Function in Primary Endogenously Depressed Men: Preliminary Findings

Pineal-Hypothalamic-Pituitary Function in Patients with Depressive Illness

Subject Index


No. of pages:
© Pergamon 1981
eBook ISBN:

About the Editor

Kjell Fuxe

Affiliations and Expertise

Department of Histology, Karolinska Institutet

Jan-Åke Gustafsson

Lennart Wetterberg

Ratings and Reviews