Steroid Biochemistry

Steroid Biochemistry

1st Edition - October 1, 2023

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  • Editor: T. M. Penning
  • Hardcover ISBN: 9780443185960

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Description

Steroid Biochemistry, Volume 688 in the Methods of Enzymology series, highlights new advances in the field, containing chapters on a variety of timely topics, including Cytochrome P450 Enzyme, Steroidogenic P450s (CYP11A1, 17A1, 21A2, 11B1, and 11B5), Steroid 17 alpha-hydroxylase/17,20-lyase (Cytochrome P450 17A1), Enzymes of Estrogen Biosynthesis, Aromatase and Steroid Sulfatase, Estrogenic 17b-Hydroxysteroid Dehydrogenase,  Hydroxysteroid Dehydrogenases (HSD), 3a-Hydroxyssteroid Dehydrogenase,  Approaches to Measuring 3b-Hydroxysteroid Dehydrogenase Type 1, 3b-Hydroxysteroid Dehydrogenase Type 2, and much more.

Key Features

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in Methods in Enzymology serials
  • Updated release includes the latest information on Steroid Biochemistry

Readership

Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

Table of Contents

  • Section I. Cytochrome P450 Enzymes
    1. Steroidogenic P450s (CYP11A1, 17A1, 21A2, 11B1, and 11B5)
    Emily Scott
    2. Steroid 17alpha-hydroxylase/17,20-lyase (Cytochrome P450 17A1)
    F. Peter Guengerich, Yasuhiro Tateishi, Kevin D. McCarty and Lu Liu

    Section 2. Enzymes of Estrogen Biosynthesis
    3. Aromatase and Steroid Sulfatase
    Debashi Ghosh
    4. Estrogenic 17b-Hydroxysteroid Dehydrogenase

    Section 3. Hydroxysteroid Dehydrogenases (HSD)
    5. 3a-Hydroxyssteroid Dehydrogenase(s)
    6. Approaches to Measuring 3b-Hydroxysteroid Dehydrogenase Type 1
    Nima Sharifi
    7. 3b-Hydroxysteroid Dehydrogenase Type 2
    8. 11b-Hydroxysteroids Dehydrogenase Type 1
    Alex Odermatt
    9. 11b-Hydroxysteroids Dehydrogenase Type 2
    Alex Odermatt
    10. 17b-Hydroxysteroid Dehydrogenases
    Tea Lanisnik Rizner

    Section 4. Steroid Reductases
    11. Approaches for evolutionary, biochemical, and structural analysis of bacterial steroid 5a-reductases
    Ren Ruobing
    12. Mammalian Steroid 5a-Reductase
    Richard J. Auchus
    13. Human Steroid 5b-Reductase (AKR1D1)
    Trevor Martin Penning
    14. Human Aldo-Keto Reductases (AKR1C1-AKR1C4)-Cloning & Expression of Recombinant Enzymes
    Trevor Martin Penning and Andrea Detlefsen

    Section 5. Steroid Conjugating Enzymes
    15. Steroid sulfotransferases-X SULT2A1, 2B1b and 1E1
    Charles Napoleon Falany
    16. Steroid UGT-Glucuronsyl Transfereases

    Section 6. Steroid Analytical Chemistry
    17. Mass spectrometry of Glucocorticiids
    18. Mass spectrometry of Progestins
    19. LC-MS Quantitation of Hydroxy- and Keto-Androgens
    Clementina Mesaros, Andrea Detlefsen and Ryan Paulukinas
    20. Quantification of 11-oxygenated androgens by RP-UV-HPLC post 2,4-dinitrophenylhydrazine derivatization
    Ryan Paulukinas
    21. 11-Oxygenated Androgens
    Amanda Swart
    22. LC-MS Quantitation of Estrogens
    Clementina Mesaros

Product details

  • No. of pages: 412
  • Language: English
  • Copyright: © Academic Press 2023
  • Published: October 1, 2023
  • Imprint: Academic Press
  • Hardcover ISBN: 9780443185960

About the Serial Volume Editor

T. M. Penning

Dr. Trevor Penning, the Thelma Brown and Henry Charles Molinoff Professor of Pharmacology, is a professor of Systems Pharmacology and Translational Therapeutics at the University of Pennsylvania and has been the Director of the Center of Excellence in Environmental Toxicology (CEET) since its founding in 2006. He formulated the strategic vision of the CEET from its inception and built the environmental health science identity of the CEET at the University, regional, and national level. As Director of the CEET, Dr. Penning has focused the center’s research around the connections between human disease and environmental exposures and emphasized the importance of using this research to mitigate health impacts on vulnerable communities both locally and globally. Throughout his time as Director, Dr. Penning has focused his research on the connections between human health and anthropogenic pollution. Air pollution is responsible for more than 200,000 deaths globally each year and has been identified as a known human carcinogen by the World Health Organization.

Affiliations and Expertise

Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, USA

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