Stem Cells

Stem Cells

Scientific Facts and Fiction

3rd Edition - January 20, 2021

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  • Authors: Christine Mummery, Anja van de Stolpe, Bernard Roelen, Hans Clevers
  • eBook ISBN: 9780128226773
  • Paperback ISBN: 9780128203378

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Description

Stem Cells: Scientific Facts and Fiction, Third Edition, provides a state-of-the-art overview on the field of stem cells and their current applications. The book incorporates the history and firsthand commentaries in the field from clinical and research leaders, covering interesting topics of note, including the first clinical trials to treat Parkinson disease, macular degeneration, and corneal replacement, the cloning of monkeys, the organoid field, and CRISPR-edited genomics. In addition, coverage of adult, embryonic stem cells and iPS cells is included. This new edition distinguishes itself from the multiplicity of websites about stem cells with a broad view of the field.

Key Features

  • Explains, in a straightforward, nonspecialist language, the basic biology of stem cells and their applications in modern medicine and future therapy
  • Provides new and expanded coverage of cloning, organoids, “synthetic” embryos, and much more
  • Includes detailed illustrations to assist users with learning on how research is done

Readership

Biotech and biomedical researchers who need to understand stem cells to enhance their work and extend collaborations; specialists in all medical disciplines

Table of Contents

  • 1. The Biology of the Cell
    2. Embryonic Development
    3. What are Stem Cells?
    4. Of Mice and Men: The History of Embryonic Stem Cells
    5. Origins and Types of Stem Cells: What’s in a Name?
    6. Cloning: History and Current Applications
    7. Regenerative Medicine: Clinical Applications of Stem Cells
    8. Stem Cells in Veterinary Medicine
    9. Cardiomyocytes from Stem Cells: What can we do with them?
    10. Adult Stem Cells: Generation of Self-Organizing Mini-Organs in a Dish
    11. Stem Cell Tourism
    12. Cancer Stem Cells: Where do they come from and where are they going?
    13. Human Stem Cells for Organ-on-Chips: Clinical Trials without Patients
    14. Stem Cells for Discovery of Effective and Safe New Drugs
    15. Patients, Opportunities, and Challenges: Legal and Intellectual Property Issues associated with Stem Cells
    16. Stem Cell Perspectives: A Vision of the Future

Product details

  • No. of pages: 424
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: January 20, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780128226773
  • Paperback ISBN: 9780128203378

About the Authors

Christine Mummery

Christine Mummery
Christine Mummery is a Professor of Developmental Biology at Leiden University Medical Centre in the Netherlands and head of the Department of Anatomy and Embryology. Her research concerns heart development and the differentiation of pluripotent human stem cells into the cardiac and vascular lineages and using these cells as disease models, for safety pharmacology, drug discovery and future cardiac repair. Immediate interests are on developing biophysical techniques for characterization and functional analysis of cardiovascular cells from hPSC. She was recently awarded a multimillion grant for this purpose and is awardee of a prestigious European Research Council Advanced Grant. A member of the Royal Netherlands Academy of Science, and former board member of the International Society of Stem Cell research and the Netherlands Medical Research Council, she’s editor in chief of the ISSCR journal Stem Cell Reports and is also on the editorial boards of Cell Stem Cell, Cardiovascular Research and Stem Cells.

Affiliations and Expertise

Leiden University Medical Centre, Leiden, the Netherland

Anja van de Stolpe

Anja van de Stolpe is Medical Scientific Advisor and Research Fellow (Senior Director level) at Philips Research. She is by background a registered clinical internist specialized in hematology with 10 years of experience in clinical internal medicine and hemato-oncology / blood coagulation in academic and peripheral hospital settings. A current research interest is innovative molecular diagnostics, especially related to oncology. She is scientifically involved in multiple translational research projects within Philips Research, ranging from circulating tumor cells to sequencing and array-based diagnostics, and oncogenic pathway modelling. She is also actively involved in Business Development, for which she received the Philips Research Entrepreneurs Award. She is cofounder and member of the Scientific Advisory Board of the stem cell company Pluriomics; and a co-founder of the European School for Science Education (ESSE) for post-academic education of medical specialists.

Affiliations and Expertise

Philips Molecular Pathway Dx, Eindhoven, The Netherlands

Bernard Roelen

Bernard Roelen is Associate professor at the Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University in Utrecht, the Netherlands. His research is focused on mammalian germ cells, early embryos stem cells and. He is author of >70 scientific publications.

Affiliations and Expertise

Utrecht University, Utrecht, The Netherlands

Hans Clevers

Hans Clevers is obtained his MD degree in 1984 and his PhD degree in 1985 from the University Utrecht, the Netherlands. His postdoctoral work (1986-1989) was done with Cox Terhorst at the Dana-Farber Cancer Institute of the Harvard University, Boston, USA. From 1991-2002 Dr. Clevers was Professor in Immunology at the University Utrecht and, since 2002, Professor in Molecular Genetics. Since 2002, he is director of the Hubrecht Institute in Utrecht. He has been a member of the Royal Netherlands Academy of Arts and Sciences since 2000 and is the recipient of several awards, including the Dutch Spinoza Award in 2001, the Swiss Louis Jeantet Prize in 2004, the Memorial Sloan-Kettering Katharine Berkan Judd Award in 2005, the Israeli Rabbi Shai Shacknai Memorial Prize in 2006, and the Dutch Josephine Nefkens Prize for Cancer Research and the German Meyenburg Cancer Research Award in 2008.

Affiliations and Expertise

Hubrecht Institute, UMC Utrecht and Utrecht University, Utrecht, The Netherlands

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