Stem Cells in Development and Disease - 1st Edition - ISBN: 9780124160224, 9780123914354

Stem Cells in Development and Disease, Volume 107

1st Edition

Serial Volume Editors: Michael Rendl
eBook ISBN: 9780123914354
Hardcover ISBN: 9780124160224
Imprint: Academic Press
Published Date: 31st January 2014
Page Count: 472
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Table of Contents



Chapter One: Mechanisms of Pluripotency In Vivo and In Vitro


1 Introduction

2 Phases of Lineage Restriction

3 First Lineage Specification—ICM Versus TE Cell Fate

4 Second Lineage Specification—EPI Versus PE Cell Fate

5 Maintenance of Early Cell Lineages—Relevance to Pluripotent Stem Cells

6 Growth Factor Signaling Requirements in EPI-Derived Stem Cells: In Vivo Similarities and Differences

7 Concluding Remarks


Chapter Two: Hematopoietic Stem Cell Development


1 Introduction

2 Principles of Epigenetic Regulation

3 Epigenetic Regulation of Hematopoiesis

4 Role of Epigenetic Regulators in Hematopoietic Malignancies

5 Conclusions


Chapter Three: Intestinal Stem Cells and Their Defining Niche


1 The Mammalian Small Intestine

2 Intestinal Stem Cells

3 Characterizing Stem Cell Behavior During Homeostasis and Disease

4 Reconciling the Opposing ISC Models

5 The Stem Cell Niche

6 Studying ISCs Ex Vivo

7 Conclusion


Chapter Four: Epithelial Stem Cells in Adult Skin


1 Introduction

2 Stem Cells in the Interfollicular Epidermis

3 Stem Cells in the Pilosebaceous Unit

4 Stem Cells in the Sweat Gland

5 Components of Adult Stem Cell Niches in the Skin

6 Stem Cells in Epithelial Skin Cancers

7 Concluding Remarks


Chapter Five: The Mammary Stem Cell Hierarchy


1 Introduction

2 Identification of Adult Mouse MaSCs

3 The Isolation of Distinct Mammary Luminal Progenitor Cells

4 In Vivo Lineage Tracing in the Mammary Gland

5 Evidence for the Existence of Fetal MaSCs

6 Elucidation of a Functionally Analogous Epithelial Hierarchy in Human Breast

7 Control of MaSCs by Steroid Hormones

8 Molecular Regulators of the Mammary Epithelial Hierarchy

9 Implications of the Differentiation Hierarchy for Breast Cancer

10 Concluding Remarks


Chapter Six: Satellite Cells


1 Introduction

2 Embryonic Origin of Satellite Cells

3 Adult Satellite Cells: A Heterogeneous Population of Stem Cells and Committed Progenitors

4 Age and Disease-Related Decline in Satellite Cell Function

5 Satellite Cell Transplantation Therapy

6 Concluding Remarks


Chapter Seven: Neural Stem Cell of the Hippocampus


1 Introduction

2 Origin of Adult Hippocampal Neural Stem Cells: Embryonic Development of the DG

3 Adult Hippocampal Neurogenesis: Heterogeneous Neurogenic NSCs and Niche

4 Adult DG NSC in Epilepsy, Aging, and Depression

5 Conclusions


Chapter Eight: Lung Stem and Progenitor Cells in Tissue Homeostasis and Disease


1 Introduction

2 Endogenous Lung Stem and Progenitor Cells

3 The Others: Lung Mesenchymal Stromal Cells and Lung Endothelial Progenitor Cells

4 Directing Differentiation: Embryonic Stem Cells and Induced Pluripotent Stem Cells

5 MSCs: Potential Role of Cell-Based Therapy in Lung Disease

6 Stem Cells in Lung Cancer

7 Future Directions


Chapter Nine: Spermatogonial Stem Cell Functions in Physiological and Pathological Conditions


1 Introduction

2 Spermatogenesis and SSC Biology

3 Origin of SSC Pool

4 Molecular Mechanisms Regulating Maintenance of the SSC Pool

5 TGCT Formation

6 Concluding Remarks

Chapter Ten: The Origin, Biology, and Therapeutic Potential of Facultative Adult Hepatic Progenitor Cells


1 Introduction

2 Conditions That Activate HPC Proliferation

3 Origins and Markers for HPCs

4 The Contribution of HPCs to Liver Regeneration

5 Signaling Pathways and Niches That Regulate the Behavior of HPCs

6 Cell Therapy

7 Concluding Remarks


Chapter Eleven: Nephron Progenitor Cells


1 Introduction

2 Setting the Scene: The Developing Urinary System of the Mammal

3 The Nephrogenic Niche

4 A Subdivision Within the Nephron Progenitor Population: Evidence for More Than One State

5 Roles Played by the CM

6 Balancing Self-Renewal and Differentiation: Signals from the Stroma

7 Influences from Other Cellular Compartments

8 Transcriptional Regulation of the CM

9 Renal Hypoplasia: Time to Reassess What We Know

10 Cessation of Nephrogenesis

11 Conclusion


Chapter Twelve: Adult Stem Cell Niches


1 Introduction

2 Cellular Organization of Adult SC Niches

3 Molecular Regulators of Adult SC Niches

4 SC Niche Dysfunction in Aging and Cancer

5 Concluding Remarks


Chapter Thirteen: Cancer Stem Cells, Pluripotency, and Cellular Heterogeneity


1 Cancer Stem Cells: An Overview

2 Control of (Cancer) Stemness by Signaling Pathways: The Embryonic/Germ Cell Connection

3 Conclusions and Future Perspective


Chapter Fourteen: Cellular Mechanisms of Somatic Stem Cell Aging


1 Introduction

2 Molecular Players of Cellular Aging

3 Extrinsic Regulation of Aged Cellular and Tissue Homeostasis

4 Aging in Tissue-Specific Stem Cells

5 Discussion and Concluding Comments




This new volume of Current Topics in Developmental Biology covers Stem Cells in Development and Disease. The chapters provide a comprehensive set of reviews covering such topics as the mechanisms of pluripotency in vivo and in vitro, hematopoietic stem cell development, intestinal stem cells and their defining niche, epithelial stem cells in adult skin, the mammary stem cell hierarchy, satellite cells, neural stem cells of the hippocampus, lung stem and progenitor cells in tissue homeostasis and disease, spermatogonial stem cell functions in physiological and pathological conditions, the origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells, nephron progenitor cells, adult stem cell niches, cancer stem cells, pluripotency and cellular heterogeneity, and cellular mechanisms of somatic stem cell aging

Key Features

  • Covers the area of Stem Cells in Development and Disease
  • International board of authors
  • Provides a comprehensive set of reviews covering such topics as Intestinal Stem Cells, Nephron Stem Cells/Progenitors, Skin epithelial Stem Cells and Lung Stem Cells


Researchers in cell, developmental, and molecular biology; genetics


No. of pages:
© Academic Press 2014
Academic Press
eBook ISBN:
Hardcover ISBN:


"...contains especially strong content on adult stem cells, as well as additional chapters that focus on the more universal themes of pluripotency itself, cancer stem cells, and aging of resident adult stem cell populations." --The Quarterly Review of Biology, Stem Cells in Development and Disease

Ratings and Reviews

About the Serial Volume Editors

Michael Rendl Serial Volume Editor

Affiliations and Expertise

Black Family Stem Cell Institute, Department of Developmental and Regenerative Biology; Icahn School of Medicine at Mount Sinai, NY, USA