Stem Cells in Development and Disease - 1st Edition - ISBN: 9780124160224, 9780123914354

Stem Cells in Development and Disease, Volume 107

1st Edition

Serial Volume Editors: Michael Rendl
eBook ISBN: 9780123914354
Hardcover ISBN: 9780124160224
Imprint: Academic Press
Published Date: 31st January 2014
Page Count: 472
Tax/VAT will be calculated at check-out Price includes VAT (GST)
30% off
30% off
30% off
30% off
30% off
20% off
20% off
30% off
30% off
30% off
30% off
30% off
20% off
20% off
30% off
30% off
30% off
30% off
30% off
20% off
20% off
160.00
112.00
112.00
112.00
112.00
112.00
128.00
128.00
128.00
89.60
89.60
89.60
89.60
89.60
102.40
102.40
210.00
147.00
147.00
147.00
147.00
147.00
168.00
168.00
Unavailable
Price includes VAT (GST)
× DRM-Free

Easy - Download and start reading immediately. There’s no activation process to access eBooks; all eBooks are fully searchable, and enabled for copying, pasting, and printing.

Flexible - Read on multiple operating systems and devices. Easily read eBooks on smart phones, computers, or any eBook readers, including Kindle.

Open - Buy once, receive and download all available eBook formats, including PDF, EPUB, and Mobi (for Kindle).

Institutional Access

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Table of Contents

Contributors

Preface

Chapter One: Mechanisms of Pluripotency In Vivo and In Vitro

Abstract

1 Introduction

2 Phases of Lineage Restriction

3 First Lineage Specification—ICM Versus TE Cell Fate

4 Second Lineage Specification—EPI Versus PE Cell Fate

5 Maintenance of Early Cell Lineages—Relevance to Pluripotent Stem Cells

6 Growth Factor Signaling Requirements in EPI-Derived Stem Cells: In Vivo Similarities and Differences

7 Concluding Remarks

Acknowledgments

Chapter Two: Hematopoietic Stem Cell Development

Abstract

1 Introduction

2 Principles of Epigenetic Regulation

3 Epigenetic Regulation of Hematopoiesis

4 Role of Epigenetic Regulators in Hematopoietic Malignancies

5 Conclusions

Acknowledgments

Chapter Three: Intestinal Stem Cells and Their Defining Niche

Abstract

1 The Mammalian Small Intestine

2 Intestinal Stem Cells

3 Characterizing Stem Cell Behavior During Homeostasis and Disease

4 Reconciling the Opposing ISC Models

5 The Stem Cell Niche

6 Studying ISCs Ex Vivo

7 Conclusion

Acknowledgments

Chapter Four: Epithelial Stem Cells in Adult Skin

Abstract

1 Introduction

2 Stem Cells in the Interfollicular Epidermis

3 Stem Cells in the Pilosebaceous Unit

4 Stem Cells in the Sweat Gland

5 Components of Adult Stem Cell Niches in the Skin

6 Stem Cells in Epithelial Skin Cancers

7 Concluding Remarks

Acknowledgments

Chapter Five: The Mammary Stem Cell Hierarchy

Abstract

1 Introduction

2 Identification of Adult Mouse MaSCs

3 The Isolation of Distinct Mammary Luminal Progenitor Cells

4 In Vivo Lineage Tracing in the Mammary Gland

5 Evidence for the Existence of Fetal MaSCs

6 Elucidation of a Functionally Analogous Epithelial Hierarchy in Human Breast

7 Control of MaSCs by Steroid Hormones

8 Molecular Regulators of the Mammary Epithelial Hierarchy

9 Implications of the Differentiation Hierarchy for Breast Cancer

10 Concluding Remarks

Acknowledgments

Chapter Six: Satellite Cells

Abstract

1 Introduction

2 Embryonic Origin of Satellite Cells

3 Adult Satellite Cells: A Heterogeneous Population of Stem Cells and Committed Progenitors

4 Age and Disease-Related Decline in Satellite Cell Function

5 Satellite Cell Transplantation Therapy

6 Concluding Remarks

Acknowledgments

Chapter Seven: Neural Stem Cell of the Hippocampus

Abstract

1 Introduction

2 Origin of Adult Hippocampal Neural Stem Cells: Embryonic Development of the DG

3 Adult Hippocampal Neurogenesis: Heterogeneous Neurogenic NSCs and Niche

4 Adult DG NSC in Epilepsy, Aging, and Depression

5 Conclusions

Acknowledgments

Chapter Eight: Lung Stem and Progenitor Cells in Tissue Homeostasis and Disease

Abstract

1 Introduction

2 Endogenous Lung Stem and Progenitor Cells

3 The Others: Lung Mesenchymal Stromal Cells and Lung Endothelial Progenitor Cells

4 Directing Differentiation: Embryonic Stem Cells and Induced Pluripotent Stem Cells

5 MSCs: Potential Role of Cell-Based Therapy in Lung Disease

6 Stem Cells in Lung Cancer

7 Future Directions

Acknowledgments

Chapter Nine: Spermatogonial Stem Cell Functions in Physiological and Pathological Conditions

Abstract

1 Introduction

2 Spermatogenesis and SSC Biology

3 Origin of SSC Pool

4 Molecular Mechanisms Regulating Maintenance of the SSC Pool

5 TGCT Formation

6 Concluding Remarks

Chapter Ten: The Origin, Biology, and Therapeutic Potential of Facultative Adult Hepatic Progenitor Cells

Abstract

1 Introduction

2 Conditions That Activate HPC Proliferation

3 Origins and Markers for HPCs

4 The Contribution of HPCs to Liver Regeneration

5 Signaling Pathways and Niches That Regulate the Behavior of HPCs

6 Cell Therapy

7 Concluding Remarks

Acknowledgments

Chapter Eleven: Nephron Progenitor Cells

Abstract

1 Introduction

2 Setting the Scene: The Developing Urinary System of the Mammal

3 The Nephrogenic Niche

4 A Subdivision Within the Nephron Progenitor Population: Evidence for More Than One State

5 Roles Played by the CM

6 Balancing Self-Renewal and Differentiation: Signals from the Stroma

7 Influences from Other Cellular Compartments

8 Transcriptional Regulation of the CM

9 Renal Hypoplasia: Time to Reassess What We Know

10 Cessation of Nephrogenesis

11 Conclusion

Acknowledgments

Chapter Twelve: Adult Stem Cell Niches

Abstract

1 Introduction

2 Cellular Organization of Adult SC Niches

3 Molecular Regulators of Adult SC Niches

4 SC Niche Dysfunction in Aging and Cancer

5 Concluding Remarks

Acknowledgments

Chapter Thirteen: Cancer Stem Cells, Pluripotency, and Cellular Heterogeneity

Abstract

1 Cancer Stem Cells: An Overview

2 Control of (Cancer) Stemness by Signaling Pathways: The Embryonic/Germ Cell Connection

3 Conclusions and Future Perspective

Acknowledgments

Chapter Fourteen: Cellular Mechanisms of Somatic Stem Cell Aging

Abstract

1 Introduction

2 Molecular Players of Cellular Aging

3 Extrinsic Regulation of Aged Cellular and Tissue Homeostasis

4 Aging in Tissue-Specific Stem Cells

5 Discussion and Concluding Comments

Acknowledgments

Index


Description

This new volume of Current Topics in Developmental Biology covers Stem Cells in Development and Disease. The chapters provide a comprehensive set of reviews covering such topics as the mechanisms of pluripotency in vivo and in vitro, hematopoietic stem cell development, intestinal stem cells and their defining niche, epithelial stem cells in adult skin, the mammary stem cell hierarchy, satellite cells, neural stem cells of the hippocampus, lung stem and progenitor cells in tissue homeostasis and disease, spermatogonial stem cell functions in physiological and pathological conditions, the origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells, nephron progenitor cells, adult stem cell niches, cancer stem cells, pluripotency and cellular heterogeneity, and cellular mechanisms of somatic stem cell aging

Key Features

  • Covers the area of Stem Cells in Development and Disease
  • International board of authors
  • Provides a comprehensive set of reviews covering such topics as Intestinal Stem Cells, Nephron Stem Cells/Progenitors, Skin epithelial Stem Cells and Lung Stem Cells

Readership

Researchers in cell, developmental, and molecular biology; genetics


Details

No. of pages:
472
Language:
English
Copyright:
© Academic Press 2014
Published:
Imprint:
Academic Press
eBook ISBN:
9780123914354
Hardcover ISBN:
9780124160224

Reviews

"...contains especially strong content on adult stem cells, as well as additional chapters that focus on the more universal themes of pluripotency itself, cancer stem cells, and aging of resident adult stem cell populations." --The Quarterly Review of Biology, Stem Cells in Development and Disease


About the Serial Volume Editors

Michael Rendl Serial Volume Editor

Affiliations and Expertise

Black Family Stem Cell Institute, Department of Developmental and Regenerative Biology; Icahn School of Medicine at Mount Sinai, NY, USA