Description

This new volume of Current Topics in Developmental Biology covers Stem Cells in Development and Disease. The chapters provide a comprehensive set of reviews covering such topics as the mechanisms of pluripotency in vivo and in vitro, hematopoietic stem cell development, intestinal stem cells and their defining niche, epithelial stem cells in adult skin, the mammary stem cell hierarchy, satellite cells, neural stem cells of the hippocampus, lung stem and progenitor cells in tissue homeostasis and disease, spermatogonial stem cell functions in physiological and pathological conditions, the origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells, nephron progenitor cells, adult stem cell niches, cancer stem cells, pluripotency and cellular heterogeneity, and cellular mechanisms of somatic stem cell aging

Key Features

  • Covers the area of Stem Cells in Development and Disease
  • International board of authors
  • Provides a comprehensive set of reviews covering such topics as Intestinal Stem Cells, Nephron Stem Cells/Progenitors, Skin epithelial Stem Cells and Lung Stem Cells

Readership

Researchers in cell, developmental, and molecular biology; genetics

Table of Contents

Contributors

Preface

Chapter One: Mechanisms of Pluripotency In Vivo and In Vitro

Abstract

1 Introduction

2 Phases of Lineage Restriction

3 First Lineage Specification—ICM Versus TE Cell Fate

4 Second Lineage Specification—EPI Versus PE Cell Fate

5 Maintenance of Early Cell Lineages—Relevance to Pluripotent Stem Cells

6 Growth Factor Signaling Requirements in EPI-Derived Stem Cells: In Vivo Similarities and Differences

7 Concluding Remarks

Acknowledgments

Chapter Two: Hematopoietic Stem Cell Development

Abstract

1 Introduction

2 Principles of Epigenetic Regulation

3 Epigenetic Regulation of Hematopoiesis

4 Role of Epigenetic Regulators in Hematopoietic Malignancies

5 Conclusions

Acknowledgments

Chapter Three: Intestinal Stem Cells and Their Defining Niche

Abstract

1 The Mammalian Small Intestine

2 Intestinal Stem Cells

3 Characterizing Stem Cell Behavior During Homeostasis and Disease

4 Reconciling the Opposing ISC Models

5 The Stem Cell Niche

6 Studying ISCs Ex Vivo

7 Conclusion

Acknowledgments

Chapter Four: Epithelial Stem Cells in Adult Skin

Abstract

1 Introduction

2 Stem Cells in the Interfollicular Epidermis

3 Stem Cells in the Pilosebaceous Unit

4 Stem Cells in the Sweat Gland

5 Components of Adult Stem Cell Niches in the Skin

6 Stem Cells in Epithelial Skin Cancers

7 Concluding Remarks

Acknowledgments

Chapter Five: The Mammary Stem Cell Hierarchy

Abstract

1 Introduction

2 Identification of Adult Mouse MaSCs

3 The Isolation of Distinct Mammary Luminal Progenitor Cells

4 In Vivo Lineage Tracing in the Mammary Gland

5 Evidence for the Existence of Fetal MaSCs

6 Elucidat

Details

No. of pages:
472
Language:
English
Copyright:
© 2014
Published:
Imprint:
Academic Press
Print ISBN:
9780124160224
Electronic ISBN:
9780123914354