Stem Cells and COVID-19

Stem Cells and COVID-19

1st Edition - April 21, 2022

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  • Editors: Chandra Sharma, Devendra Agrawal, Finosh Thankam
  • Paperback ISBN: 9780323899727
  • eBook ISBN: 9780323886239

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Description

Stem Cells and COVID-19 presents up-to-date knowledge on the effect of hematopoietic and mesenchymal stem cells to combat SARS-CoV-2 infection in its diagnosis, treatment and prevention. In addition, the book critically discusses challenges, highlighting outstanding questions and future perspectives. Written by global experts in the field for both pre-clinical and clinical practitioners, this comprehensive book delves into how stem cells have a strong potential in developing better diagnostic, treatment and preventive strategies in SARS-CoV-2 infection. Both hematopoietic and mesenchymal stem cells are critical to better understand the response of immune system to coronavirus infection in both healthy and co-morbid conditions in the development of effective vaccines and immunotherapies.

Key Features

  • Focuses on diagnosis, treatment and prevention
  • Presents different aspects to enable researchers in the field to move toward designing novel therapeutics in the treatment of COVID-19
  • Provides coverage of challenges and future perspectives in this fast-moving field

Readership

Researchers in universities, various translational research laboratories, pharma industries and also graduate students

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Contributors
  • Preface
  • 1: Introduction
  • References
  • 2: Characteristics and immunobiology of COVID-19
  • Abstract
  • Introduction
  • Structure and etiology
  • Pathology of infection
  • Immunology and signaling mechanisms
  • Cytokine storm
  • Current treatment approaches
  • Translational avenues and perspectives
  • References
  • 3: An insight into the molecular mechanisms of mesenchymal stem cells and their translational approaches to combat COVID-19
  • Abstract
  • Introduction and background
  • Pathophysiology of SARS-CoV-2
  • Conventional and contemporary translational approaches to combat COVID-19
  • Stem cell therapy as a novel translation approach against the COVID-19 pandemic
  • Conclusion and outlook for the future
  • References
  • 4: Inflammatory multisystem syndrome in COVID-19: Insights on off-target organ system in susceptible and recovering population
  • Abstract
  • Introduction
  • Antigen processing and immune responses in COVID-19
  • Cytokine storm
  • Inflammation in COVID-19
  • Respiratory system failure
  • Cardiovascular manifestations in COVID-19
  • Neurological and renal manifestation of COVID-19
  • GI tract manifestations
  • Conclusion
  • Acknowledgment
  • References
  • 5: Cytokine storm and stem cell activation in unveiling potential targets for diagnosis and therapy
  • Abstract
  • Acknowledgments
  • Introduction
  • Cytokine storms
  • Cytokine storms in viral respiratory infections
  • Cytokine storms and stem cells
  • Conclusion
  • References
  • 6: Mesenchymal stem cells: Novel avenues in combating COVID-19
  • Abstract
  • Introduction
  • Alveolar cell and SARS-COVID-19
  • Cytokine storm
  • The reason behind using mesenchymal stem cells
  • Conclusion
  • References
  • 7: Immunomodulatory properties of mesenchymal stem cells and hematopoietic stem cells—Potential therapeutic target for COVID-19
  • Abstract
  • Acknowledgments
  • Introduction
  • MSC as a cellular therapy
  • Hematopoietic stem cells
  • Translational potential of MSCs
  • Conclusion
  • References
  • 8: COVID-19 and acute myocardial injury: Stem cell driven tissue remodeling in COVID-19 infection
  • Abstract
  • Introduction
  • COVID-19: Etiology, transmission, structure, and pathophysiology
  • COVID-19-CVD comorbidity
  • Stem cells in cardiac remodeling
  • ACE2 signaling and cardiac pathology COVID-19 infection
  • Stem cell activation and signaling in ACE2 upregulation
  • Cytokine surge and stem cell activation in MI
  • Sheddases’ response in cardiac stem cell differentiation (major focus to TMPRSS2, CTSL, and ADAM17)
  • Perspectives in COVID-19 and cardiac responses
  • Translational avenues and future
  • References
  • 9: Stem cell-driven tissue regeneration as treatment for COVID-19
  • Abstract
  • Introduction
  • Management of COVID-19 by stem cells
  • Stem cell activation during pathology
  • Growth factors as a vital target
  • COVID-19 clinical trials
  • Summary and significance
  • References
  • 10: Stem cell transplantation for COVID-19 management: Translational possibilities and future
  • Abstract
  • Introduction
  • Sources of stem cells
  • Use of different types of stem cells in translational research
  • Current COVID-19 related clinical trials using stem cells
  • Challenges of using stem cells and future perspective
  • Conclusion
  • References
  • 11: Therapeutic scale stem cell-derived exosomes for COVID-19: Models—Validation, management, and strategies
  • Abstract
  • Introduction to Covid-19
  • Pathophysiology
  • Interventions
  • Stem cell population/product condition addressed outcome
  • Exosome for management
  • Exosome challenges
  • References
  • 12: Current strategies and future perspectives in COVID-19 therapy
  • Abstract
  • Acknowledgments
  • Introduction
  • COVID-19: An overview
  • COVID-19 diagnosis
  • Current treatment strategies
  • Future perspectives
  • Conclusion
  • References
  • Index

Product details

  • No. of pages: 248
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: April 21, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323899727
  • eBook ISBN: 9780323886239

About the Editors

Chandra Sharma

Dr. Chandra P. Sharma is former Senior Scientist G and Head, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Trivandrum and has been Head, Biosurface Technology Division, SCTIMST, Trivandrum from January 1980 to February 2014. He has also been Associate Head, Biomedical Technology Wing, and Associate Dean, PhD Affairs, SCTIMST Trivandrum. Presently he is Adjunct Professor, Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal University. His basic activities relate understanding of blood/tissue – material interactions at the interface. In case of chitosan, an encouraging wound healing material, his group demonstrated during 1990s that its hemostatic potential is independent of classical coagulation cascade and appears to be an interaction between the cell membrane of erythrocytes and chitosan. His research interests include: biomaterials and artificial organs and nano-systems for oral delivery of insulin.

Affiliations and Expertise

Adjunct Professor, Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India

Devendra Agrawal

Dr. Devendra K. Agrawal moved to Canada and earned PhD (Medical Sciences) in 1984 from McMaster University, Canada followed by a Postdoctoral Fellowship at the University of British Columbia, Vancouver, Canada. In 1985, he was recruited as an Asst Professor at Creighton University School of Medicine, Omaha, Nebraska where he rose to the rank of Full Professor in 1997. Dr. Agrawal also earned MBA in 2004 and MS in 2005 from Creighton University. In 2009, Dr. Agrawal founded the Center for Clinical & Translational Research at Creighton University, which later developed into an independent Department. Dr. Agrawal was the Founding Chairman of this Department. Dr. Agrawal also served as the Senior Associate Dean of Clinical & Translational Sciences at Creighton. In July 2019, he moved to California as Senior Vice President for Research and Professor of Translational Research at the Western University of Health Sciences, Pomona, CA.

Affiliations and Expertise

Senior Vice President for Research and Professor, Translational Research, Western University of Health Sciences, Pomona, California, USA

Finosh Thankam

Dr. Finosh Thankam is an assistant professor and researcher in Tissue Engineering and Regenerative Medicine, in the Department of Translational Research, at the Western University of Health Sciences, in Pomona, CA. His undergraduate studies were in Biochemistry, before completing his post-graduate degree in Medical Biochemistry from Mahatma Gandhi University, in India. As a research fellow he was exposed to the new world of tissue engineering and regenerative medicine and published many original articles on various aspects of cardiac tissue engineering. His current research interests include investigating the pathogenesis of various musculoskeletal disorders, and cardiovascular diseases, and applying the knowledge and principles of tissue engineering to develop artificial tissue constructs to improve the care for the sufferers.

Affiliations and Expertise

Assistant Professor, Tissue Engineering and Regenerative Medicine, Department of Translational Research, Western University of Health Sciences, Pomona, California, USA

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