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Stem Cells and COVID-19 - 1st Edition - ISBN: 9780323899727

Stem Cells and COVID-19

1st Edition

Editors: Chandra Sharma Devendra Agrawal Finosh Thankam
Paperback ISBN: 9780323899727
Imprint: Academic Press
Published Date: 2nd May 2022
Page Count: 300
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Stem cells have a strong potential in developing better diagnostic, treatment and preventive strategies in SARS-CoV-2 infection. Both hematopoietic and mesenchymal stem cells are critical to better understand the response of immune system to coronavirus infection in both healthy and co-morbid conditions in the development of effective vaccines and immunotherapies.

Stem Cells and COVID-19 presents up-to-date knowledge on the effect of hematopoietic and mesenchymal stem cells to combat SARS-CoV-2 infection in its diagnosis, treatment and prevention, critically discuss the challenges, highlight outstanding questions and future perspectives. Written by global experts in the field for both pre-clinical and clinical practitioners.

Key Features

  • Focuses on diagnosis, treatment and prevention
  • Presents different aspects to enable researchers in the field to move toward designing novel therapeutics in the treatment of COVID-19
  • Provides coverage of the challenges and future perspectives in this fast-moving field


Researchers in universities, various translational research laboratories, pharma industries and also graduate students

Table of Contents

  1. Introduction
    2. Characteristics and Immunobiology of COVID19
    3. Molecular Mechanism and translation approaches
    4. Inflammatory multisystem syndrome in COVID19: Insights on off-target organ system in susceptible and recovering population
    5. Cytokine storm and stem cell activation in unveiling potential targets for diagnosis and therapy
    6. Mesenchymal and hematopoietic stem cells: Novel avenues in combating COVID19
    7. Immunomodulatory properties of mesenchymal and hematopoietic stem cells – potential therapeutic target for COVID-19
    8. COVID19 and acute myocardial injury: Stem cell driven tissue remodeling in COVID19 infection
    9. Stem cell born signals and tissue regeneration in COVID19 infection
    10. Stem cell transplantation COVID19 management: Translational possibilities and future
    11. Therapeutic scale stem cell-derived exosomes for COVID - 19: Models – Validation, Management & Strategies
    12. Therapy: present & future clinical perspective


No. of pages:
© Academic Press 2022
2nd May 2022
Academic Press
Paperback ISBN:

About the Editors

Chandra Sharma

Dr. Chandra P. Sharma is former Senior Scientist G and Head, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Trivandrum and has been Head, Biosurface Technology Division, SCTIMST, Trivandrum from January 1980 to February 2014. He has also been Associate Head, Biomedical Technology Wing, and Associate Dean, PhD Affairs, SCTIMST Trivandrum. Presently he is Adjunct Professor, Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal University. His basic activities relate understanding of blood/tissue – material interactions at the interface. In case of chitosan, an encouraging wound healing material, his group demonstrated during 1990s that its hemostatic potential is independent of classical coagulation cascade and appears to be an interaction between the cell membrane of erythrocytes and chitosan. His research interests include: biomaterials and artificial organs and nano-systems for oral delivery of insulin.

Affiliations and Expertise

Adjunct Professor, Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India

Devendra Agrawal

Dr. Devendra K. Agrawal moved to Canada and earned PhD (Medical Sciences) in 1984 from McMaster University, Canada followed by a Postdoctoral Fellowship at the University of British Columbia, Vancouver, Canada. In 1985, he was recruited as an Asst Professor at Creighton University School of Medicine, Omaha, Nebraska where he rose to the rank of Full Professor in 1997. Dr. Agrawal also earned MBA in 2004 and MS in 2005 from Creighton University. In 2009, Dr. Agrawal founded the Center for Clinical & Translational Research at Creighton University, which later developed into an independent Department. Dr. Agrawal was the Founding Chairman of this Department. Dr. Agrawal also served as the Senior Associate Dean of Clinical & Translational Sciences at Creighton. In July 2019, he moved to California as Senior Vice President for Research and Professor of Translational Research at the Western University of Health Sciences, Pomona, CA.

Affiliations and Expertise

Senior Vice President for Research and Professor, Translational Research, Western University of Health Sciences, Pomona, California, USA

Finosh Thankam

Dr. Finosh Thankam is an assistant professor and researcher in Tissue Engineering and Regenerative Medicine, in the Department of Translational Research, at the Western University of Health Sciences, in Pomona, CA. His undergraduate studies were in Biochemistry, before completing his post-graduate degree in Medical Biochemistry from Mahatma Gandhi University, in India. As a research fellow he was exposed to the new world of tissue engineering and regenerative medicine and published many original articles on various aspects of cardiac tissue engineering. His current research interests include investigating the pathogenesis of various musculoskeletal disorders, and cardiovascular diseases, and applying the knowledge and principles of tissue engineering to develop artificial tissue constructs to improve the care for the sufferers.

Affiliations and Expertise

Assistant Professor, Tissue Engineering and Regenerative Medicine, Department of Translational Research, Western University of Health Sciences, Pomona, California, USA

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