- Chromatin in pluripotency
2. Epigenetic regulation of reprogramming
3. DNA methylation regulation of stem cells
4. Histone modifications in stem cells and differentiation
5. Higher-order chromatin conformation in pluripotent cells
6. Epigenetics and disease modelling
7. Organoids from pluripotent cells
8. Transcriptional regulation in stem cells and differentiation
9. Non-coding RNAs in pluripotency and early differentiation
Growing evidence suggests that epigenetic mechanisms play a central role in stem cell biology, vital for determining gene expression during cellular differentiation and governing mammalian development. In Stem Cell Epigenetics, leading international researchers examine how epigenetics are involved in stem cell differentiation, how a stem cell rapidly transitions into a molecularly distinct cell type, and how this process may be reversed or managed via epigenetic reprogramming. Topics discussed include chromatin in pluripotency, epigenetic regulation of reprogramming, stem cells and DNA methylation, histone modifications in stem cells and differentiation, higher-order chromatin conformation in pluripotent cells, epigenetics and disease modeling, organoids from pluripotent cells, transcriptional regulation in stem cells and differentiation, non-coding RNAs in pluripotency and early differentiation, and diseases caused by epigenetic alterations in stem cells. Additionally, the potential implementation of stem cell epigenetics in drug discovery, regenerative medicine, and disease treatment is discussed in detail, helping researchers and physicians bring this exciting and fast evolving field to the clinic.
- Offers an in-depth analysis of the role epigenetics play in regulating embryonic stem cell differentiation and mammalian development
- Provides genetic researchers, students, and physicians with evidence indicating epigenetic mechanisms involved in stem cell differentiation, highlighting those epigenetic modifications and misregulations that may result in disease pathogenesis
- Examines the potential application of stem cell epigenetics towards developing therapeutic interventions for disease and advancing regenerative medicine, providing a foundation for researchers and physicians to bring this exciting and fast evolving field to the clinic
- Features chapter contributions by leading international experts
Researchers, clinicians and graduate students in genomic medicine, epigenetics, stem cell epigenetics, and stem cell biology
- No. of pages:
- © Academic Press 2019
- 1st November 2018
- Academic Press
- Hardcover ISBN:
The Meshorer lab, which has received funding from various Israeli and international organizations, studies nuclear processes in embryonic and neuronal stem cells, as well as in pluripotent models of neurodegenerative diseases, including chromatin dynamics and structure, nuclear architecture, transcription and splicing as well as epigenetic processes, in attempt to understand the mechanisms governing self-renewal, pluripotency and neuronal differentiation and function. Dr. Meshorer has published widely in the fields of stem cell epigenetics and stem cell biology, with over seventy-five papers published in peer reviewed journals. Dr. Meshorer received his PhD in molecular neuroscience at Hebrew University in 2003. Additionally, he has received awards and honors from Hebrew University, the National Institute for Psychobiology of Israel, the Israeli Council for Higher Education, and the University of Sydney.
Associate Professor, Department of Genetics, The Institute of Life Sciences, The Edmond and Lily Safra Center for Brain Sciences (ELSC), Hebrew University of Jerusalem, Israel
where he is also Deputy Principal Investigator in the Research Unit on Biomedical Humanities. He is the cofounder of the interdisciplinary PhD program FOLSATEC (Foundations of the Life Sciences and Their Ethical Consequences) in Milan. His lab focuses on modeling disease through cell reprogramming, epigenetic regulation of neural fate, and aberrant genome programming in brain cancer, and he has received funding from various Italian and international organizations including European Research Council Consolidator Grant, the Italian Association for Cancer Research, the Italian Health Ministry, the Association for International Cancer Research, the Italian National Research Council, and the Federation of European Biochemical Societies. Dr. Meshorer has published widely in the fields of stem cell epigenetics and molecular medicine, with over forty-five papers published in peer reviewed journals.
Laboratory of Stem Cell Epigenetics, European Institute for Oncology (IEO), Milan, Italy