Stem Cell Epigenetics

Stem Cell Epigenetics

1st Edition - August 5, 2020

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  • Editors: Eran Meshorer, Giuseppe Testa
  • eBook ISBN: 9780128140864
  • Hardcover ISBN: 9780128140857

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Description

Growing evidence suggests that epigenetic mechanisms play a central role in stem cell biology and are vital for determining gene expression during cellular differentiation and governing mammalian development. In Stem Cell Epigenetics, leading international researchers examine how chromatin regulation and bona fide epigenetic mechanisms underlie stem cell renewal and differentiation. Authors also explore how the diversity of cell types, including the extent revealed by single cell omic approaches, is achieved, and how such processes may be reversed or managed via epigenetic reprogramming.Topics discussed include chromatin in pluripotency, stem cells and DNA methylation, histone modifications in stem cells and differentiation, higher-order chromatin conformation in pluripotent cells, stem cells and cancer, epigenetics and disease modeling, brain organoids from pluripotent cells, transcriptional regulation in stem cells and differentiation, non-coding RNAs in pluripotency and early differentiation, and diseases caused by epigenetic alterations in stem cells. Additionally, the book discusses the potential implementation of stem cell epigenetics in drug discovery, regenerative medicine, and disease treatment. Stem Cell Epigenetics will provide researchers and physicians with a state-of-the-art map to orient across the frontiers of this fast-evolving field.

Key Features

  • Analyzes the role of epigenetics in embryonic stem cell regulation
  • Indicates the epigenetic mechanisms involved in stem cell differentiation and highlights modifications and misregulations that may result in disease pathogenesis
  • Examines the potential applications of stem cell epigenetics in therapeutic disease interventions and regenerative medicine, providing a foundation for researchers and physicians to bring this exciting and fast-evolving field into a clinical setting
  • Features chapter contributions by leading international experts

Readership

Researchers, clinicians and graduate students in genomic medicine, epigenetics, stem cell epigenetics, and stem cell biology

Table of Contents

  • 1. Epigenetic processes and DNA repair in embryonic stem cells
    2. Stem cell epigenomics
    3. A change in culture; modelling human germ cell development in vitro
    4. Higher order chromatin structure
    5. Polycomb
    6. Mitotic bookmarking by transcription factors and the preservation of pluripotency
    7. Roles and regulation of endogenous retroviruses in pluripotency and early development
    8. Single stem cell biology
    9. Stem cell chromatin plasticity
    10. Transcriptional and epigenetic regulatory mechanisms in glioblastoma
    11. 3D Models of the Human Brain
    12. Stem cell epigenetic proteomics

Product details

  • No. of pages: 318
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: August 5, 2020
  • Imprint: Academic Press
  • eBook ISBN: 9780128140864
  • Hardcover ISBN: 9780128140857

About the Series Volume Editors

Eran Meshorer

Prof. Meshorer is the Arthur Gutterman Family Chair for Stem Cell research. He completed his PhD at the Hebrew University and performed his post-doctoral studies at the National Cancer Institute, NIH. In 2007, he returned to the Hebrew University as an Alon Fellow and is currently heading the ‘Epigenetics, Stem cells & Neurons’ laboratory in the Department of Genetics and the Edmond and Lily Safra Center for Brain Sciences (ELSC). Meshorer's lab research focuses on single cell and genome-wide approaches to understand chromatin plasticity and epigenetic regulation in embryonic and neuronal stem cells, during reprogramming, and in pluripotent models of neurodegenerative diseases. Meshorer’s lab identified the unique features of chromatin plasticity in pluripotent stem cells, the mechanisms supporting chromatin plasticity in pluripotent cells, developed epigenomic tools for the stem cell community, and established unique neurodegenerative disease models in human pluripotent stem cells. In recent years, Prof. Meshorer co-pioneered the field of Paleo-epigenetics, having reconstructed the first DNA methylation maps of ancient genomes, including the Neanderthal and the Denisovan, a method which led to the first reconstruction of the Denisovan and the 2019 ‘Breakthrough of the year’ award by Science magazine. Prof. Meshorer has been a past and/or present member of five European consortium’s, one of which (EpiSyStem), he currently coordinates. He also currently serves on the International Society for Stem Cell Research (ISSCR) Publication Committee, is a board member of several national societies, and he is the current Head of the Department of Genetics, institute of Life Sciences, Hebrew University.

Affiliations and Expertise

The Arthur Gutterman Family Chair in Stem Cell Biology; Full Professor of Molecular Biology, Department of Genetics, The Institute of Life Sciences and The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem, Israel

Giuseppe Testa

Giuseppe Testa holds an MD from the University of Perugia, a PhD from the European Molecular Biology Laboratory in Heidelberg, and an MA in Health Care Ethics and Law from the University of Manchester. A three-time European Research Council (ERC) awardee, Prof. Giuseppe Testa is Full Professor of Molecular Biology at the University of Milan, Head of the Center for Neurogenomics of the Human Technopole and Director of the High Definition Disease Modelling Laboratory at the European Institute of Oncology. His lab spearheads stem cell and organoid-based patient-specific models for neurodevelopmental disorders and cancer, focusing on genetic and environmental causes of chromatin dysregulation as a shared and increasingly relevant layer of pathogenic mechanisms. Starting from densely phenotyped clinical cohorts and integrating multi-layered omics, single cell dynamics and high-end computing, the aim is to advance a foundational framework for precision oncology and neuropsychiatry. Key accomplishments include the development of new genome engineering technologies, the characterization of novel enzymes required for neural development, the first reprogramming-based models of human diseases caused by symmetric gene dosage imbalances, the single cell omics-based mechanistic dissection of human corticogenesis in brain organoids, and the identification of the master regulator gene underlying the evolution of the modern human face. A further unique accomplishment is the successful pursuit of a parallel career as practicing life scientist and scholar in Bioethics and Science and Technology Studies (STS). His first book ‘Naked genes: Reinventing the Human in the Molecular Age’, co-authored with Helga Nowotny, published in German, English and Italian, was widely reviewed in the leading press. He is the recipient of several scientific prizes, including in 2003 the Roche Prize for leading bioscientist of the next decade.

Affiliations and Expertise

Full Professor of Molecular Biology, Department of Oncology and Hemato-Oncology, University of Milan; Head of the Center for Neurogenomics, Human Technopole; Director of the High Definition Disease Modelling Laboratory, European Institute of Oncology, Milan, Italy

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