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Woodhead Publishing Series in Biomaterials
Part I: Methods for cell and tissue engineering
Chapter 1: Fundamentals of cell and matrix biology for tissue engineering
1.2 Extracellular matrices (ECMs)
1.3 ECM and cell interaction
1.4 ECM and mechanical signalling
1.5 Future trends
Chapter 2: Three-dimensional collagen biomatrix development and control
2.1 Engineering cell-rich and matrix-rich tissues using collagen scaffolds
2.2 Controlling the mechanical properties of collagen
2.3 Architectural features: introducing elements of tissue complexity
2.4 Future trends
Chapter 3: Two- and three-dimensional tissue culture bioprocessing methods for soft tissue engineering
3.2 Bioreactor configurations
3.3 Selecting scaffold materials and architectures for your bioreactor
3.4 Mass transfer in tissue engineering bioreactors
3.5 Important parameters and taking measurements of bioreactor cultures
3.6 Tissue engineering process design
3.7 Future trends
3.9 Sources of further information and advice
Chapter 4: Two- and three-dimensional tissue culture methods for hard tissue engineering
4.2 Culture of bone and cartilage cells
4.3 Cell culture parameters: bone tissue culture
4.4 Cell culture parameters: cartilage tissue culture
4.5 Two-dimensional tissue culture methods for hard tissues
4.6 Two-and-a-half- and three-dimensional tissue culture methods for hard tissues
Chapter 5: Vascularisation of tissue-engineered constructs
5.2 Growth of healthy vessels â€’ embryonic vasculogenesis
5.3 Angiogenic diseases
5.4 Angiogenesis and bone formation
5.5 Cell sources for vascular tissue engineering
5.6 Co-culture of cells: the interactions between angiogenesis and osteogenesis
5.7 Strategies to induce in vitro prevascularisation
5.8 Tubular formation
Part II: Standards and protocols in cell and tissue engineering
Chapter 6: Standards in cell and tissue engineering
6.2 How and by whom are standards produced?
6.3 The importance of an agreed lexicon
6.4 Drivers for standardization
6.5 How will standards help me?
6.6 What standards currently exist in tissue engineering?
6.7 Characterization of biomaterials and biomolecules
6.8 Characterization of tissue scaffolds
6.9 Characterization of cell-seeded scaffolds
6.10 Manufacture, processing and storage
6.11 Characterization of cells and cell-surface interactions
Chapter 7: Principles of good laboratory practice (GLP) for in vitro cell culture applications
7.2 GLP governing bodies
7.3 Resources required for GLP compliance
7.5 Standards and regulations
7.6 Documentation of results
7.7 Independent monitoring of research processes and quality assurance (QA) personnel
7.8 Application of GLP to human cell culture systems
Chapter 8: Quality control in cell and tissue engineering
8.2 Quality control to ensure a well-defined cell therapy product
8.3 Commercial quality control/quality assurance in large-scale manufacture
Chapter 9: Standardised chemical analysis and testing of biomaterials
9.1 Introduction: why we need standard methods for testing biomaterials
9.2 Standardised chemical analysis: when and why we assess chemistries
9.3 Chemical properties
9.4 Imaging methods for measuring porosity
9.5 Physical characterisation – permeability
9.6 Surface properties
9.7 Degradation and stability in physiological fluids
9.8 Implant–tissue interface tests
9.9 Limitations of current standardised testing methods
Chapter 10: Sterilisation procedures for tissue allografts
10.2 Interaction of ionising radiation with matter
10.3 Sources of ionising radiation
10.4 Validation and international standards of sterilisation by ionising radiation
10.5 Conclusions and future trends
10.6 Sources of further information and advice
Chapter 11: Commercial manufacture of cell therapies
11.1 Introduction: cells as therapies
11.2 The transition from laboratory to commercial- scale manufacture of cell therapies
11.3 Key regulatory requirements for commercial manufacture of cell therapies
11.4 Cell-based therapy versus monoclonal antibody therapies: lessons from existing biopharmaceutical manufacture
The increased use of biodegradable synthetic or natural scaffolds combined with cells and/or biological molecules, in order to create functional replacement tissue in a damaged tissue site, has led to the need for the development of ‘best practice’ methods in the area of tissue engineering to help ensure the creation of safe, high quality products. Standardisation in cell and tissue engineering introduces concepts and current practice in the field of cell and tissue engineering to a wide audience and aims to provide awareness of the importance of standardisation in this area while suggesting directions for further investigation.
Part one provides an overview of methods for cell and tissue engineering and includes chapters on the fundamentals of cell and matrix biology for tissue engineering, 3D collagen biomatrix development, and control and vascularisation of tissue-engineered constructs. Part two begins with a chapter exploring the methods and protocols of standardisation in cell and tissue engineering before moving on to highlight issues of quality control in cell and tissue engineering, standardised chemical analysis and testing of biomaterials and principles of good laboratory practice (GLP) for in vitro cell culture applications.
Standardisation in cell and tissue engineering is a standard reference for leading research groups, government agencies, regulatory bodies, and researchers and technicians at all levels across the whole range of disciplines using cell culture within the pharmaceutical, biotechnology and biomedical industries.
- Introduces concepts and current practice in the field of cell and tissue engineering
- Highlights the importance of standardisation in cell and tissue engineering and suggests directions for further investigation
- Explores methods and protocols of standardisation in cell and tissue engineering and issues of quality control in cell and tissue engineering
Biomaterials scientists; Tissue and cell engineers
- No. of pages:
- © Woodhead Publishing 2013
- 31st July 2013
- Woodhead Publishing
- Hardcover ISBN:
- eBook ISBN:
"...a comprehensive overview of the current standards in cell and tissue engineering, and biomaterials, which is of interest to a broad public including biologists, biomedical engineers and chemists."--Biomat.net, December 2014
“A text such as this is needed to begin (at last) to crystalize some of the most common concepts and approaches and alert early entrants or students to the need for, and demands of standardisation…as a teaching primer and as a dip-in reference book, this is a really useful text.”--MaterialsView.com,July 1, 2014
Dr Vehid Salih is Reader at Peninsula Dental School, Plymouth University Schools of Medicine and Dentistry, UK.
Plymouth University Schools of Medicine and Dentistry, UK
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