Spine Phenotypes - 1st Edition - ISBN: 9780128227787

Spine Phenotypes

1st Edition

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Editors: Dino Samartzis
Hardcover ISBN: 9780128227787
Imprint: Academic Press
Published Date: 1st October 2020
Page Count: 300
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The era of personalized spine care has arrived. Within that, imaging and clinical phenotypes are key in establishing personalized algorithms for patient care. This is particularly important in developing novel diagnostics and therapeutics as well as predicting outcomes and establishing preventative measures for various spinal disorders. Spine Phenotypes is a comprehensive resource that outlines phenotype descriptions, their radiographic measurement and epidemiological classification and provides an in-depth discussion regarding spine pathology and its clinical relevance.

Multi-authored, with multi-disciplinary contributions from world leaders in the field of imaging, spine research and clinical practice, each chapter is rich in visual depiction of imaging phenotypes, providing examples of some established phenotypic measurements with a range of normal and pathologic images.

Spine Phenotypes will be a first of its kind reference for researchers, orthopedists, spine specialists and many more.

Key Features

  • Book chapters devoted to specific imaging phenotypes with discussion of their clinical correlates
  • Imaging phenotypes provided with examples of established phenotypic measurements and a range of normal and pathologic images
  • Multi-author, multi-disciplinary contributions comprising world leaders in the field of imaging, spine research and clinical practice


Researchers, Orthopedists, Spine Specialists (including chiropractors, physiatrists, physical therapists, neurosurgeons, pain management physicians and many rheumatologists and neurologists). Medical Students, Nurses, Residents, Physician Assistants, and Undergraduate Students

Table of Contents

  1. Anatomy of the spine
    2. Biomechanics of the spine
    3. Biomechanical models to study spinal phenotypes
    4. Animal models to study spinal phenotypes
    5. Imaging technologies of the spine
    6. Disc degeneration
    7. Osteophytes and disc space narrowing
    8. Disc displacement
    9. High intensity zones and radial tears
    10. Vertebral endplate changes, abnormalities, and defects
    11. Subchondral bone marrow changes (Modic)
    12. Spinal ligament changes and abnormalities
    13. Spinal stenosis
    14. Facet joint changes and orientation
    15. Muscle morphology, changes and association with spinal phenotypes
    16. Spinal alignment


No. of pages:
© Academic Press 2021
1st October 2020
Academic Press
Hardcover ISBN:

About the Editor

Dino Samartzis

Dr. Samartzis obtained his undergraduate degree from Northwestern University, and further pursued graduate studies in biological sciences, evidence-based health care, clinical epidemiology, medical sciences, and international studies at Harvard University, University of Oxford (UK), University of Cambridge (UK), Erasmus University (The Netherlands), Charles University (Czech Republic), and London School of Economics and Political Science (UK). He completed a postdoctoral fellowship at the The University of Hong Kong. He went on to become the Gilbert Beebe Fellow of the Radiation and Nuclear Board of the National Academies of Science in Washington D.C. and the United States Department of Energy, the Radiation Epidemiology Branch of the National Institutes of Health in Bethesda, Maryland, and at the Radiation Effects Research Foundation (a.k.a. Atomic Bomb Casualty Commission) in Hiroshima, Japan. He has published over 350 peer-reviewed studies in high-impact journals (e.g., Lancet, Arthritis & Rheumatism, JBJS, etc.), book chapters and web-based articles.

Affiliations and Expertise

Director, International Spine Research and Innovation Initiative (ISRII) and an Associate Professor, Department of Orthopedic Surgery, Rush Medical College

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