Spinal Interneurons

Spinal Interneurons

Plasticity after Spinal Cord Injury

1st Edition - September 1, 2022

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  • Editors: Lyandysha Zholudeva, Michael Lane
  • Paperback ISBN: 9780128192603

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Spinal Interneurons: Plasticity after Spinal Cord Injury provides neuroscientists, clinicians and trainees a reference book exclusively concentrating on spinal interneurons and the techniques and experiments employed to identify and study these cells as part of normal, diseased and injured neural circuits. In addition, the book highlights the therapeutic potential of these cells by presenting relevant pre-clinical and clinical work that has been performed. The book's focus on the latest in therapeutic strategies for targeting spinal interneurons, considerations for the development and use of treatments, and how such treatments work make this a comprehensive source of information.

Key Features

  • Provides a comprehensive overview of the techniques used to identify, characterize and classify spinal interneurons and their role in neural circuits
  • Presents an in-depth discussion of the therapeutic potential of spinal interneurons for SCI injury and/or disease
  • Represents the first book to discuss spinal interneurons and translational research


Neuroscientists, clinicians, and trainees with an interest in the spinal cord

Table of Contents

  • Section 1: Spinal Interneurons: Motor and Sensory Neuronal Networks
    1. Spinal Interneurons: coordination and modulation in the adult spinal cord
    2. Identifying spinal interneurons: lessons from developmental biology and genetics
    3. Spinal Interneurons and Motor Function
    4. Spinal interneurons and Sensory Function
    5. Lessons from computational models

    Section 2: Spinal Interneurons: A role in injury and disease
    6. Spinal interneurons after spinal cord injury: Adaptive vs maladaptive neuroplasticity
    7. Spinal interneurons and Breathing
    8. Spinal interneurons and Bladder function
    9. Spinal interneurons and Pain
    10. Spinal interneurons in pre-clinical models of ALS

    Section 3: Spinal Interneurons: A therapeutic target for plasticity, repair and recovery
    11. Introduction: Therapeutic potential of spinal interneurons Electrical stimulation

Product details

  • No. of pages: 300
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: September 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780128192603

About the Editors

Lyandysha Zholudeva

After completing her Bachelor of Science in Chemistry with a Minor in Biophysics at Creighton University, where she used non-invasive imaging techniques for quantifying cellular metabolism, Lyandysha (Lana) Zholudeva then pursued her doctoral work with Dr. Michael Lane in the Department of Neurobiology & Anatomy, and the Marion Murray Spinal Cord Research Center at Drexel University. After completing her graduate thesis on transplanting neural progenitor cells to repair respiratory networks of the injured cervical spinal cord, with a focus on improving respiratory function, she began a postdoctoral position at the Gladstone Institutes with Dr. Todd McDevitt, where she is focusing on engineering human spinal interneurons for spinal cord repair and disease modeling. Her research aims to identify spinal interneuronal subsets that can be engineered from human induced pluripotent stem cells for transplantation and spinal cord repair.

Affiliations and Expertise

Gladstone Institutes, University of California, San Francisco, CA, USA

Michael Lane

Dr. Michael Aron Lane is an Associate Professor in the Department of Neurobiology and Anatomy at the Drexel University College of Medicine. He is a Primary Investigator at the Spinal Cord Research Center. His research focuses on spinal cord injury, neuroplasticity and strategies to optimize lasting functional recovery. He also served as a lecturer in the annual NIH-funded Spinal Cord Injury Training Program at The Ohio State University from 2009 to 2013.

Affiliations and Expertise

Drexel University College of Medicine, Department of Neurobiology and Anatomy, Philadelphia, PA, USA

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