This book covers, in a broad perspective, research on spinal cord injury, beginning with human spinal cord injury to experimental studies in animals, to molecular mechanisms of injury and regeneration.

Every year 12,000 will suffer spinal cord injury leading to permanent disability. In the last five years enormous progress has been made in the understanding of spinal cord injury, and in ways to elicit repair in animal models of spinal cord injury. The scope includes animal models of spinal cord injury, strategies for neuroprotection and regeneration, and possible roles of axon guidance molecules in injury and regeneration. Topical reviews are presented as well as new data on timely issues in spinal cord injury research.

Table of Contents

List of contributors. Foreword by Christopher Reeve. Preface. Section I. Spinal Cord Injuries in Patients. 1. Advances in imaging of spinal cord injury: implications for treatment and patient evaluation (R.M. Quencer). 2. A review of the adaptability and recovery of locomotion after spinal cord injury (H. Barbeau et al.). 3. Electrical stimulation for therapy and mobility after spinal cord injury (R.B. Stein et al.). Section 2. Spinal Cord Injuries in Animal Models. 4. Cell death in models of spinal cord injury (M.S. Beattie et al.). 5. Gray matter repair in the cervical spinal cord (P.J. Reier et al.). 6. Spinal cord neural organization controlling the urinary bladder and striated sphincter (S.J. Shefchyk). 7. Central mechanisms for autonomic dysreflexia after spinal cord injury (L.C. Weaver et al.). 8. The spinal locomotor CPG - a target after spinal cord injury (S. Grillner). 9. Activation and coordination of spinal motoneuron pools after spinal cord injury (A. Prochazka et al.). 10. Propriospinal neurons involved in the control of locomotion: potential targets for repair strategies? (L.M. Jordan, B.J. Schmidt). 11. Use of robotics in assessing the adaptive capacity of the rat lumbar spinal cord (R.D. de Leon et al.). 12. The cat model of spinal injury (S. Rossignol et al.). Section 3. Neuroprotection and transplantation. 13. Neurotrauma/neurodegeneration and mitochondrial dysfunction (M. Frantseva et al.). 14. Secondary injury mechanisms of spinal cord trauma: a novel therapeutic approach for the management of secondary pathophysiology with the sodium channel blocker Riluzole (G. Schwartz, M.G. Fehlings). 15. Strategies for regeneration and repair in spinal cord traumatic injury (M. Giménez y Ribotta et al.). 16. Locomotor recovery in chronic spinal rat: long-term pharmacol


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© 2002
Elsevier Science
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