Description

Handbook of Clinical Neurology: Spinal Cord Injury summarizes advances in the clinical diagnosis, monitoring, prognostication, treatment, and management of spinal cord injuries. More specifically, it looks at new and important developments in areas such as high-resolution noninvasive neuroimaging, surgery, and electrical stimulation of motor, respiratory, bladder, bowel, and sexual functions. It also reviews the latest insights into spontaneous regeneration and recovery of function following rehabilitation, with emphasis on novel therapeutic strategies, such as gene therapy, transcranial stimulation, brain-machine interfaces, pharmacological approaches, molecular target discovery, and the use of olfactory ensheathing cells, stem cells, and precursor cells.

Organized in five sections, the book begins with an overview of the development, maturation, biomechanics, and anatomy of the spinal cord before proceeding with a discussion of clinical diagnosis and prognosis as well as natural recovery, ambulation, and function following spinal cord injury. It then examines clinical neurophysiology in the prognosis and monitoring of traumatic spinal cord injury; medical, surgical and rehabilitative management of spinal cord trauma; and some new approaches for improving recovery in patients, including restoration of function by electrical stimulation, locomotor training, and the use of robotics. Other chapters cover cell transplantation, artificial scaffolds, experimental pharmacological interventions, and molecular and combinatorial strategies for repairing the injured spinal cord. This volume should be of interest to neuroscience and clinical neurology research specialists and practicing neurologists.

Key Features

  • Comprehensive coverage of the latest scientific understanding of spinal cord injuries
  • Detailed coverage of current treatment best practices and potential future treatments
  • Connects leading edge research programs to future treatment opportunities

Readership

Neuroscience and Clinical Neurology research specialists and practicing neurologists

Table of Contents

Handbook of Clinical Neurology 3rd Series

Foreword

Preface

List of contributors

Chapter 1. Development and maturation of the spinal cord

Gross embryology

Cellular and molecular embryology of the spine

Spinal cord maldevelopment

Conclusion

References

Chapter 2. Anatomy and biomechanics of the spinal column and cord

Introduction

Biomechanics: the basic concepts

Biomechanics of spinal column failure

Biomechanics of spinal cord injury

Conclusions

References

Chapter 3. Clinical diagnosis and prognosis following spinal cord injury

Introduction

Assessing injury severity following spinal cord injury

Natural recovery following traumatic spinal cord injury

Ambulation and function following spinal cord injury

The role of imaging for prognosis and functional recovery

References

Chapter 4. Clinical neurophysiology in the prognosis and monitoring of traumatic spinal cord injury

Introduction

Evaluation of sensory function

Evaluation of motor function

Autonomic evaluation

Conclusions

References

Chapter 5. Concepts of aging with paralysis

Introduction

Pathophysiology of the aging nervous system

Etiology and clinical presentation of spinal cord injury in elderly subjects

Complications and mortality

Influence of age on outcome and length of stay for rehabilitation

Aging following a spinal cord injury

References

Chapter 6. Advanced MRI strategies for assessing spinal cord injury

Introduction

Assessment of macromolecular composition, tissue orientation, and organization

Functional and metabolic markers for tissue health

What to do when the therapeutic intervention requires placement of metal hardware for stabilization

Final comments 

Details

No. of pages:
656
Language:
English
Copyright:
© 2012
Published:
Imprint:
Elsevier
Print ISBN:
9780444521378
Electronic ISBN:
9780444535078

Reviews

"Providing the latest information on all aspects of spinal cord injury, this volume supplants a 1992 work published in the Handbook of Clinical Neurology series titled Spinal Cord Trauma. Bridging the gap between bench and bedside, coverage encompasses diagnosis and prognosis; medical, surgical, and rehabilitative management of acute spinal cord injury; therapies for chronic spinal cord injury; and preclinical research." --Reference and Research Book News, October 2013