Handbook of Clinical Neurology: Spinal Cord Injury summarizes advances in the clinical diagnosis, monitoring, prognostication, treatment, and management of spinal cord injuries. More specifically, it looks at new and important developments in areas such as high-resolution noninvasive neuroimaging, surgery, and electrical stimulation of motor, respiratory, bladder, bowel, and sexual functions. It also reviews the latest insights into spontaneous regeneration and recovery of function following rehabilitation, with emphasis on novel therapeutic strategies, such as gene therapy, transcranial stimulation, brain-machine interfaces, pharmacological approaches, molecular target discovery, and the use of olfactory ensheathing cells, stem cells, and precursor cells. Organized in five sections, the book begins with an overview of the development, maturation, biomechanics, and anatomy of the spinal cord before proceeding with a discussion of clinical diagnosis and prognosis as well as natural recovery, ambulation, and function following spinal cord injury. It then examines clinical neurophysiology in the prognosis and monitoring of traumatic spinal cord injury; medical, surgical and rehabilitative management of spinal cord trauma; and some new approaches for improving recovery in patients, including restoration of function by electrical stimulation, locomotor training, and the use of robotics. Other chapters cover cell transplantation, artificial scaffolds, experimental pharmacological interventions, and molecular and combinatorial strategies for repairing the injured spinal cord. This volume should be of interest to neuroscience and clinical neurology research specialists and practicing neurologists.

Key Features

*Comprehensive coverage of the latest scientific understanding of spinal cord injuries
*Detailed coverage of current treatment best practices and potential future treatments
*Connects leading edge research programs to future treatment opportunities 


Neuroscience and Clinical Neurology research specialists and practicing neurologists.

Table of Contents

Handbook of Clinical Neurology 3rd Series



List of contributors

Chapter 1. Development and maturation of the spinal cord

Gross embryology

Cellular and molecular embryology of the spine

Spinal cord maldevelopment



Chapter 2. Anatomy and biomechanics of the spinal column and cord


Biomechanics: the basic concepts

Biomechanics of spinal column failure

Biomechanics of spinal cord injury



Chapter 3. Clinical diagnosis and prognosis following spinal cord injury


Assessing injury severity following spinal cord injury

Natural recovery following traumatic spinal cord injury

Ambulation and function following spinal cord injury

The role of imaging for prognosis and functional recovery


Chapter 4. Clinical neurophysiology in the prognosis and monitoring of traumatic spinal cord injury


Evaluation of sensory function

Evaluation of motor function

Autonomic evaluation



Chapter 5. Concepts of aging with paralysis


Pathophysiology of the aging nervous system

Etiology and clinical presentation of spinal cord injury in elderly subjects

Complications and mortality

Influence of age on outcome and length of stay for rehabilitation

Aging following a spinal cord injury


Chapter 6. Advanced MRI strategies for assessing spinal cord injury


Assessment of macromolecular composition, tissue orientation, and organization

Functional and metabolic markers for tissue health

What to do when the therapeutic intervention requires placement of metal hardware for stabilization

Final comments 


No. of pages:
© 2012
Print ISBN:
Electronic ISBN:

About the editors

Joost Verhaagen

Affiliations and Expertise

Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

John McDonald

Affiliations and Expertise

Executive Vice President and Director, The International Center for Spinal Cord Injury, Baltimore, MD, USA


"Providing the latest information on all aspects of spinal cord injury, this volume supplants a 1992 work published in the Handbook of Clinical Neurology series titled Spinal Cord Trauma. Bridging the gap between bench and bedside, coverage encompasses diagnosis and prognosis; medical, surgical, and rehabilitative management of acute spinal cord injury; therapies for chronic spinal cord injury; and preclinical research."--Reference & Research Book News, October 2013