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Solid-Phase Peptide Synthesis - 1st Edition - ISBN: 9780121821906, 9780080884011

Solid-Phase Peptide Synthesis, Volume 289

1st Edition

Editors in Chief: John Abelson Melvin Simon
Serial Volume Editor: Gregg Fields
eBook ISBN: 9780080884011
Imprint: Academic Press
Published Date: 21st October 1997
Page Count: 780


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Table of Contents

B. Merrifield, Concept and Early Development of Solid-Phase Peptide Synthesis. Methods for Solid-Phase Assembly of Peptides: P.F. Alewood, D. Alewood, L. Miranda, S. Love, W. Meutermans, and D. Wilson, Rapid in Situ Neutralization Protocols for Boc and Fmoc Solid-Phase Chemistries. J.M. Stewart, Cleavage Methods Following Boc-Based Solid-Phase Peptide Synthesis. D.A. Wellings and E. Atherton, Standard Fmoc Protocols. C.G. Fields and G.B. Fields, Trifluoroacetic Acid Cleavage and Deprotection of Resin-Bound Peptides Following Synthesis by Fmoc Chemistry. M. Meldal, Properties of Solid Supports. F. Albericio and L.A. Carpino, Coupling Reagents and Activation. M.F. Songster and G. Barany, Handles in Solid-Phase Peptide Synthesis. C. Blackburn and S.A. Kates, Solid-Phase Synthesis of Cyclic Homodetic Peptides. I. Annis, B. Hargittai, and G. Barany, Disulfide Bond Formation in Peptides. J. Kihlberg, M. Elofsson, and L.A. Salvador, Direct Synthesis of Glycosylated Amino Acids from Carbohydrate Peracetates and Fmoc Amino Acids: Solid-Phase Synthesis of Biomedicinally Interesting Glycopeptides. J.W. Perich, Synthesis of Phosphopeptides Using Modern Chemical Approaches. S.B.H. Kent, Chemoselective Ligation. A.C. Braisted, J.K. Judice, and J.A. Wells, Synthesis of Proteins by Subtiligase. F. Albericio, P. Lloyd-Williams, and E. Giralt, Convergent Solid-Phase Synthesis. M. Lebl and V.Krchnak, Peptide Libraries. Analytical Techniques: G.A. Grant, M.W. Crankshaw, and J. Gorka, Edman Sequencing as Tool for Characterization of Synthetic Peptides. A.J. Smith, Amino Acid Analysis. C.T. Mant, L.H. Kondejewski, P.J. Cachia, O.D. Monera, and R.S. Hodges, Analysis of Synthetic Peptides by High-performance Liquid Chromatography. A. Sanchez and A.J. Smith, Capillary Electrophoresis. S. Beranova-Giorgianni and D.M. Desiderio, Fast Atom Bombardment Mass Spectrometry of Synthetic Peptides. D.J. Burdick and J.T. Stults, Analysis of Peptide Synthesis Products by Electrospary Ionization Mass Spectrometry. W.T. Moore, Laser Desorption. Specialized Applications: T.W. Muir, P.E. Dawson, M.C. Fitzgerald, and S.B.H. Kent, Protein Signature Analysis for Studying Structure-Activity Relationships in Peptides and Proteins. J.L. Lauer and G.B. Fields, In Vitro Incorporation of Synthetic Peptides into Cells. Y-C. Yu, T. Pakalns, Y.Dori, J.B. McCarthy, M. Tirrell, and G.B. Fields, Construction of Biologically Active Protein Molecular Architecture Using Self-Assembling Peptide-Amphiphiles. E. Barbar, C. Woodward, and G. Barany, Nuclear Magnetic Resonance Characterization of Synthetically Derived Partially Folded Proteins. J.P. Tam and J.C. Spetzler, Multiple Antigen Peptide System. J.D. Wade and G.W. Tregear, Relaxin. K.H. Mayo, Solution Nuclear Magnetic Resonance Characterization of Peptide Folding. T.A. Cross, Solid-State NMR Characterization of the Gramicidin Channel Structure. R.H. Angeletti, L.F. Bonewald, G.B. Fields, Six-Year Study of Peptide Synthesis. Index.


The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volumehas been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 275 volumes have been published (all of them still in print) and much of the material is relevant even today-truly an essential publication for researchers in all fields of life sciences.

Key Features

@introbul:Key Features @bul:* Solid-phase peptide synthesis

  • Applications of peptides for structural and biological studies
  • Characterization of synthetic peptides


Biochemists, molecular biologists, immunologists, cell biologists, pharmacologists, and biomedical researchers.


No. of pages:
© Academic Press 1997
21st October 1997
Academic Press
eBook ISBN:


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About the Editors in Chief

John Abelson

Affiliations and Expertise

California Institute of Technology, Division of Biology, Pasadena, U.S.A.

Melvin Simon

Affiliations and Expertise

The Salk Institute, La Jolla, CA, USA

About the Serial Volume Editor

Gregg Fields

Affiliations and Expertise

Biomedical Engineering Center, University of Minnesota, Minneapolis, U.S.A.