Small GTPases in Disease, Part A

Small GTPases in Disease, Part A

1st Edition - April 25, 2008
This is the Latest Edition
  • Editors: W. Balch, Channing Der, Alan Hall
  • Hardcover ISBN: 9780123739681
  • eBook ISBN: 9780080877600

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The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 400 volumes (all of them still in print), the series contains much material still relevant today—truly an essential publication for researchers in all fields of life sciences. Methods in Enzymology is now available online at ScienceDirect — full-text online of volumes 1 onwards. For more information about the Elsevier Book Series on ScienceDirect Program, please visit: This volume is the first of two planned volumes on the topic of small GTPases and their role in disease.


Researchers in academics and industry studying biochemistry.

Table of Contents

  • Chapter 1
    Rab1b silencing using small interfering RNA for analysis of disease specific function
    Darren M. Hutt, William E. Balch

    Chapter 2
    Rab8-optineurin-myosin VI: Analysis of interactions and functions in the secretory pathway
    Margarita V. Chibalina, Rhys C. Roberts, Susan D. Arden, John Kendrick-Jones and Folma Buss

    Chapter 3
    Characterization of Rab27a and JFC1 as constituents of the secretory machinery of prostate specific antigen in prostate carcinoma cells
    Sergio D. Catz

    Chapter 4
    In vitro assays to characterize inhibitors of the activation of small G proteins by their guanine nucleotide exchange factors
    Jean-Christophe Zeeh, Bruno Antonny, Jacqueline Cherfils, Mahel Zeghouf

    Chapter 5
    Analysis of small GTPase function in trypanosomes
    Mark C. Field, David Horn and Mark Carrington

    Chapter 6
    Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis
    Tom Kirchhausen, Eric Macia, Henry E. Pelish

    Chapter 7
    Identification and verification of Sro7p as an effector of the Sec4p rab GTPase
    Bianka Grosshans1 and Peter Novick

    Chapter 8
    Characterization of Rab18, a Lipid Droplet Associated Small GTPase
    Sally Martin, Robert G. Parton

    Chapter 9
    Analysis on the Emerging Role of of Rab3 GTPase-activating Protein in Warburg Micro and Martsolf Syndrome
    Ayuko Sakane, Jun Miyoshi, Yoshimi Takai, Takuya Sasaki

    Chapter 10
    Identification and Characterization of JRAB/MICAL-L2, a Junctional Rab13-binding Protein
    Noriyuki Nishimura and Takuya Sasaki

    Chapter 11
    A SMAP Gene Family Encoding ARF GTPase-activating Proteins and Its Implication in Membrane Trafficking

    Chapter 12
    In vitro and in vivo analysis of neurotrophin-3 activation of Arf6 and Rac-1.
    Pedro F. Esteban, Paola Caprari, Hye-Young Yoon, Paul A. Randazzo & Lino Tessarollo

    Chapter 13
    Methods for analysis of rab27a/munc13-4 in secretory lysosome release in haematopoietic cells
    Peter van der Sluijs, Maaike Neeft, Thijs van Vlijmen, Edo Elstak, and Marnix Wieffer

    Chapter 14
    Analysis and expression of Rab38 in Oculocutaneous Lung Disease
    Kazuhiro Osanai, Dennis R. Voelker

    Chapter 15
    Analysis of Rab1 function in cardiomyocyte growth
    Guangyu Wu, Catalin M. Filipeanu, Fuguo Zhou

    Chapter 16
    Regulation of the Trafficking and Function of G Protein-coupled Receptors by Rab1 GTPase in Cardiomyoctyes
    Guangyu Wu

    Chapter 17
    Regulation of endosome dynamics by Rab5 and its Huntingtin-HAP40 effector complex in physiological versus pathological conditions
    Arun Pal, Fedor Severin, Sebastian Höpfner and Marino Zeria

    Chapter 18
    Sonia Terrillon and Dafna Bar-Sagi

    Chapter 19
    Biochemical Characterization of Novel Germline BRAF and MEK Mutations in Cardio-facio-cutaneous Syndrome
    Pablo Rodriguez-Viciana and Katherine A. Rauen

    Chapter 20
    Biochemical and biological characterization of tumor-associated mutations of p110a
    Adam Denley, Marco Gymnopolous, Jonatha R. Hart, Hao Jiang, Li Zhao, Peter K. Vogt

    Chapter 21
    Characterization of the Rheb-mTOR signaling pathway in mammalian cells:
    Constitutive active mutants of Rheb and mTOR
    Tatsuhiro Sato, Akiko Umetsu, Fuyuhiko Tamanoi

    Chapter 22
    Characterization of RalB-Sec5-TBK1 Function in Human Oncogenesis
    Yuchen Chien and Michael A. White

    Chapter 23
    High-throughput lung cancer cell line screening for genotype-correlated sensitivity to an EGFR kinase inhibitor
    Ultan McDermott, Sreenath V. Sharma, Jeffrey Settleman

    Chapter 24
    In vitro signalling by MAPK and NFkB pathyways inhibited by Yersinia YopJ
    Sohini Mukherjee, Kim Orth

    Chapter 25
    Biological and biochemical characterization of anthrax lethal factor, a proteolytic inhibitor of MEK signaling pathways.
    Jennifer L. Bromberg-White and Nicholas S. Duesbery

    Chapter 26
    Genetic analyses of the role of RCE1 in RAS membrane association and transformation
    Martin O. Bergo, Annika M. Wahlstrom, Loren G. Fong, Stephen G. Young

    Chapter 27
    Characterization of Kras Mediated Pancreatic Tumorigenesis in Zebrafish
    Jon M. Davison, Seung Woo Park, Jerry M. Rhee, Steven D. Leach

    Chapter 28
    Genetic Modeling of Ras-Induced Human Rhabdomyosarcoma
    Corinne M. Linardic, Christopher M. Counter

Product details

  • No. of pages: 512
  • Language: English
  • Copyright: © Academic Press 2008
  • Published: April 25, 2008
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123739681
  • eBook ISBN: 9780080877600

About the Serial Volume Editors

W. Balch

Affiliations and Expertise

The Scripps Research Institute, La Jolla, CA, USA

Channing Der

Affiliations and Expertise

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA

Alan Hall

Affiliations and Expertise

University College of London, U.K.