Slow Brain Oscillations of Sleep, Resting State and Vigilance, Volume 193

1st Edition

Serial Volume Editors: E J Van Someren
Hardcover ISBN: 9780444538390
eBook ISBN: 9780444538383
Imprint: Elsevier
Published Date: 23rd August 2011
Page Count: 384
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Table of Contents



Slow brain oscillations of sleep, resting state, and vigilance


Slow oscillations of sleep: When, where, who, and why?

Even slower: The when, where, who, and why of ISOs


Electrophysiological correlates of sleep homeostasis in freely behaving rats

Behavior and brain activity in waking and sleep

Global and local regulation of sleep

Homeostatic sleep pressure is reflected in the amplitude and slopes of sleep slow waves

Homeostatic sleep pressure is reflected in slopes of the early and late components of electrically evoked cortical responses

Increased homeostatic sleep pressure affects cortical plasticity

Homeostatic sleep pressure is reflected in synchronization of cortical neurons

Concluding remarks


Involvement of cytokines in slow wave sleep


IL1β and TNFα in sleep regulation

Upstream and downstream events in the cytokine sleep regulatory cascade

Brain organization of sleep

Sleep function


Genetic determination of sleep EEG profiles in healthy humans


Sleep–wake regulation

Heritability of waking EEG

Trait-like nature of sleep and sleep EEG characteristics

Heritability of sleep EEG

Genetic polymorphisms affecting sleep and sleep EEG

Concluding remarks


Developmental aspects of sleep slow waves



Characteristics of slow waves

Development of slow waves—disparities in infants, children and adolescents

Developmental aspects and their relation to the function of slow waves

Slow waves and their relation to behavior

Discussion of the inverted U-shape time course of SWA

Conclusion and future perspe


This volume of Progress in Brain Research documents research presented at the 26th International Summer School of Brain Research (Amsterdam, Jun/Jul 2010) and looks at how the oscillations that characterize brain activity vary between task performance - the EEG power and performance modulations, rest - the MRI default mode and other networks, and sleep - the cortical slow oscillations. Studies over the past decade indicate that the study of these slow oscillations is essential for our understanding of plasticity, memory, brain structure from synapse to default mode network, cognition, consciousness and ultimately for our understanding of the mechanisms and functions of sleep and vigilance.

Key Features

  • Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research
  • Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
  • All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist


Neuroscientists, psychologists, neurologists


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About the Serial Volume Editors

E J Van Someren Serial Volume Editor

Affiliations and Expertise

Netherlands Institute for Neuroscience, VU University Amsterdam, The Netherlands