Skin Tissue Models

Skin Tissue Models provides a translational link for biomedical researchers on the interdisciplinary approaches to skin regeneration. As the skin is the largest organ in the body, engineered substitutes have critical medical application to patients with disease and injury – from burn wounds and surgical scars, to vitiligo, psoriasis and even plastic surgery. This volume offers readers preliminary description of the normal structure and function of mammalian skin, exposure to clinical problems and disease, coverage of potential therapeutic molecules and testing, skin substitutes, models as study platforms of skin biology and emerging technologies.

The editors have created a table of contents which frames the relevance of skin tissue models for researchers as platforms to study skin biology and therapeutic approaches for different skin diseases, for clinicians as tissue substitutes, and for cosmetic and pharmaceutical industries as alternative test substrates that can replace animal models.

• Offers descriptions of the normal structure/function of mammalian skin, exposure to clinical problems, and more
• Presents coverage of skin diseases (cancer, genodermatoses, vitiligo and psoriasis) that extends to clinical requirements and skin diseases in vitro models
• Addresses legal requirements and ethical concerns in drugs and cosmetics in vitro testing
• Edited and authored by internationally renowned group of researchers, presenting the broadest coverage possible

Researchers in regenerative medicine, tissue engineering, cell biology and biomedical engineering; clinicians in dermatology and plastic surgery

Section 1 – Therapeutic Molecules and Cosmetics Testing
1. Cosmetic industry requirements regarding skin models for cosmetic testing
Christian Pellevoisin, Charbel Bouez, José Cotovio
2. Overall perspective on the clinical importance of skin models
Yusef Yousuf, Saeid Amini-Nik, Marc G. Jeschke,

Section 2 - Skin Diseases: clinical demands and diseased-skin in vitro models
3. In vitro models of Melanoma
Dagmar Kulms, Friedegund Meier
4. Organotypic and humanized animal models of genodermatoses
Esteban Chacón-Solan, Sara Guerrero-Aspizua, Lucía Martínez-Santamaría, Marcela Del Rio, Fernando Larcher
5. In vitro models of Psoriasis
Bryan Roy, Mélissa Simard, Isabelle Lorthois, Audrey Bélanger, Maxim Maheux, Alexandra Duque-Fernandez, Geneviève Rioux, Philippe Simard, Marianne Deslauriers, Louis-Charles Masson, Alexandre Morin and Roxane Pouliot
6. In vitro models of Vitiligo
Muriel Cario-André, Katia Boniface, François-Xavier Bernard, Alain Taieb, Maria Lucia Dell’Anna, Julien Seneschal
7. In vitro models of squamous cell carcinoma
Elizabeth Pavez Loriè, Hans-Jürgen Stark, Manuel Berning, Petra Boukamp

Section 3 – Skin Substitutes: Clinical demands and skin tissue equivalents
8. Strategies to promote the vascularization of skin substitutes after transplantation
Jennifer Bourland, Julie Fradette
9. On the path to scarring-free skin regeneration approaches
Mohammed Ashrafi, Adam Hague, Mohamed Baguneid, Teresa Alonso-Rasgado, Ardeshir Bayat
10. Pre-clinical Models for Wound Healing Studies
Irena Pastar, Liang Liang, Andrew P Sawaya, Tongyu Cao Wikramanayake, George D Glinos, Stephan Drakulich, Vivien Chen, Olivera Stojadinovic, Stephen C Davis, and Marjana Tomic-Canic
11. The importance of targeting inflammation in skin regeneration
Megan Schrementi, Lin Chen, Luisa Ann DiPietro

Section 4 – In Vitro Models as study platforms of skin Biology
12. In Vitro Models to study hair follicles generation
Ana Korosec, Beate Maria Lichtenberger
13. In Vitro Models to study cutaneous innervation mechanisms
Nicolas Lebonvallet, Christelle Le Gall-Ianotto, Jérémy Chéret, Raphaël Leschiera, Matthieu Talagas, Raphaële Le Garrec, Virginie Buhé, Killian L’herondelle, Olivier Gouin, Mehdi Sakka, Nicholas Boulais, Ulysse Pereira, Jean-Luc Carré, Laurent Misery
14. Skin in vitro models to study dermal white adipose tissue role in skin healing
Manuela E. L. Lago, Mariana T. Cerqueira, Rogério P. Pirraco, Rui L. Reis, Alexandra P. Marques
15. Immunocompetent in vitro skin models
Victoria Hutter, Stewart B Kirton, David YS Chau

Section 5 - Emerging technologies for the development of 3D skin models
16. Additive manufacturing in the development of 3D skin models
Kelsey Retting, Deborah G. Nguyen
17. Induced Pluripotent Stem Cells Potential to generate skin tissue models
Olga Kashpur, Avi Smith, Nailia Mukhamedshina, Jeremy Baskin, Yulia Shamis, Kyle Hewitt, Behzad Gerami-Naini, Jonathan A. Garlick
18. Requirements of skin tissue models for high throughput screening
Stephanie H. Mathes, Christian N. Parker