Site Specific and Global Epigenomic Editing

Site Specific and Global Epigenomic Editing

Principles and Applications

1st Edition - November 1, 2022

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  • Editor: Feng Zhou
  • Paperback ISBN: 9780128193983

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Description

Site Specific and Global Epigenomic Editing: Principles and Applications, Volume 33 highlights the expanding role that epigenetics plays in pathogenesis, the full range of sites for possible epigenetic modification, and the potential to target these sites to modulate disease progression. The book answers key questions, including which of the hundreds of epigenomic marks and features are relevant, and which are likely to serve a role in regulating gene expression, cell behavior and phenotypic outcomes. This volume is the first to provide a thorough, conceptual introduction to epigenetic regulation and a thorough accounting of sites for possible epigenetic edits and disease modulation. Included protocols and applied case studies examine early disease targets and likely pathways of therapeutic significance while also outlining common challenges in the field. The book addresses its topic in a comprehensive, but accessible manner, highlighting practical tools and burning questions remaining in the field to enable fresh research.

Key Features

  • Offers a full, conceptual and applied framework for implementing epigenomic editing in biological research and drug discovery
  • Discusses fundamental theory, experimental design and applied approaches alongside common research challenges and bioethical concerns
  • Examines epigenomic editing’s potential role in the modulation of developmental, neuropsychiatric and immunological disorders, as well as in viral infections and cancer

Readership

Human geneticists; human genomicists; translational researchers in genomic medicine, epigenetics; life science researchers; oncologists; immunologists; bioengineers; developmental biologists; pharmacologists in industry and academia; clinicians and graduate students in epigenetics and genomic medicine

Table of Contents

  • Part I EPIGENETICS AND EPIGENOMICS
    1. Epigenetic editing: Progress and Challenges 
    2. Epigenetic dynamics: Normal progression and abnormal alteration 
    3. Epigenomic landscape 
    4. Histone coding and its compounding influence on gene expression
    5. microRNA as a tool for gene regulation
    6. RNA editing and genetic influence 
    7. Epitranscription: Scope and engineering ability

    Part II GLOBAL EPIGENETIC EDITING
    8. Global epigenetic editing uses methods of DNA methylation alteration drugs
    9. Regulating DNA methylation for developmental disorders
    10. Histone modification drug the HDACi: Selectivity and promise
    11. Histone modification in cancer treatment
    12. Alteration of DNA Methylation in gastric cancer
    13. Epigenetic therapy for the treatment of epithelial ovarian cancer
    14. Epigenetic application on allergy treatment
    15. HDACi therapy for the treatment of depression
    16. Histone modification on neurodevelopmental and neuropsychiatric disorders
    17. Epigenetics and Addiction
    18. Epigenetic Treatment of Persistent Viral Infections
    19. MicroRNA as strategy of gene regulation

    Part III SITE SPECIFIC EPIGENETIC EDITING
    20. Strategy and Molecular tools for site-specific editing 
    21. Site-specific recruitment of epigenetic factors for spatio-temporal epigenetic editing. 
    22. Monitoring CRISPR-Cas9 mediated DNA-methylation-editing 
    23. Locus-specific editing of histone modifications
    24. Functional DNA methylation and epigenetic editing on proneuron genes during neuroglial differentiation
    25. Epigenetic editing through regulating CRISPR-Cas9 mediated non-coding RNA
    26. Epigenetic editing targeting a parkinsonian gene  
    27. Cancer gene epigenetic editing 
    28. Epigenetic editing to unveil epigenetic mechanism of breast cancer
    29. Editing DNA Methylation on Fragile X syndrome 
    30. Can RNA editing be engineered?
    31. Genetic and epigenetic interactive approaches

    Part IV TRANSLATIONAL AND CLINIC APPLICATION
    32. Tuning DNA methylation in treating breast cancer: 
    33. Imminent Epigenetic editing in cancer treatment
    34. Epigenetic editing for developmental disorders
    35. Epigenetic editing on genetic imprinting
    36. Prospective epigenetic treatment on Neurological disease
    37. Epigenetic alterations and personalized treatment in cancer

    Part V CLOSING VIEW
    38. Obstacles and prospective of changing epigenetic codes
    39. Ethical matters in modification of epigenetic codes
    40. Future epigenetic treatment

Product details

  • No. of pages: 704
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: November 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780128193983

About the Editor

Feng Zhou

Dr. Feng C. Zhou is Professor Emertus of Anatomy and Cell Biology at Indiana University School of Medicine, Indianapolis, Indiana. In his research, Dr. Zhou studies genetic contributions to gene expression that underpin the neurochemical and neuroanatomical differences contributing to alcohol addiction. His previous research has demonstrated that alcohol alters expression cohorts of neural specification genes, and cell cycling genes in the canonical developmental pathways. In recent years, Dr. Zhou has expanded his research to include the genomics and epigenetics of alcoholism, epigenetic editing by optogenetics, cell-wide DNA de-methylation and re-methylation of purkinje neurons in the developing cerebellum, and environmental alterations of epigenetics prior to the birth, among other topics. Dr. Zhou has published widely in scientific, peer reviewed journals including Scientific Reports, PLoS ONE, Oncotarget, Frontiers in Genetics, Brain Research, Cell Transplantation, and Alcohol.

Affiliations and Expertise

Professor of Anatomy, Cell Biology, Neuroscience, and Psychology, Emeritus; Adjunct Professor of Behavioral Psychology, Northwestern University, Indianapolis, IN, USA

About the Serial Editor

Trygve Tollefsbol

Trygve Tollefsbol is a Professor of Biology and a Senior Scientist in the Comprehensive Center for Healthy Aging, the Comprehensive Cancer Center, the Nutrition Obesity Research Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol has doctorate degrees in molecular biology and osteopathic medicine and has edited and co-authored numerous books on the topics of epigenetics, cancer and aging and is Series Editor of Translational Epigenetics. Dr. Tollefsbol is a Professor of Biology and a Senior Scientist in the Center for Aging, Comprehensive Cancer Center, Nutrition Obesity Research Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999 and a Steering Committee Member of the UAB Center for Aging.

Affiliations and Expertise

Professor of Biology, Senior Scientist, Comprehensive Cancer Center, Comprehensive Center for Healthy Aging, University of Alabama at Birmingham, AL, USA

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