Sirtuin Biology in Medicine

Sirtuin Biology in Medicine

Targeting New Avenues of Care in Development, Aging, and Disease

1st Edition - February 25, 2021

Write a review

  • Editor: Kenneth Maiese
  • eBook ISBN: 9780128141199
  • Paperback ISBN: 9780128141182

Purchase options

Purchase options
DRM-free (Mobi, EPub, PDF)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order


Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease provides a fascinating and in-depth analysis of sirtuins in the body during normal physiology as well during disease highlighting the targeting of sirtuin-controlled pathways for the development of innovative, efficacious, and safe therapeutic strategies for multiple disorders in the body that ultimately can affect lifespan extension. Sirtuins are expressed throughout the body, have broad biological effects, and can significantly impact both cellular survival and longevity during acute and long-term illnesses. These histone deacetylases play an intricate role in the pathology, progression, and treatment of several disease entities ranging from neurodegenerative disorders, cardiovascular disease, immune system dysfunction, reproductive dysfunction, endocrine disorders, gastrointestinal disease, drug dependency, and aging-related disorders. Implementing a translational medicine format, this unique reference highlights novel signaling pathways for sirtuins that promote stem cell proliferation, enhance cellular protection, modulate pathways of apoptosis and autophagy, and extend life span. Each chapter is presented with insightful detail that will be of interest and a comprehensive resource to audiences that include scientists, physicians, pharmaceutical industry experts, nutritionists, and students.

Key Features

  • Chapters are authored by internationally recognized experts who discuss the broad role of sirtuins in health and disease
  • Details the basic and clinical role of sirtuins for the development of new clinical treatments
  • Summarizes the multidiscipline views and publications for the compelling discipline of sirtuins by covering systems throughout the body
  • Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings


Researchers (endocrinologists, cell biologists, molecular biologists, pharmacologists, vascular biologists, neuroscientists, etc.), Physicians (all disciplines including internal medicine, oncologists, neurologists, psychiatrists, cardiologists, etc.), pharmaceutical industry experts

Table of Contents

  • Section I: Sirtuins, neurodegenerative disease, lifespan extension, and aging
    1. Novel treatment strategies for neurodegenerative disease with sirtuins
    Kenneth Maiese
    2. NAD1: a crucial regulator of sirtuin activity in aging
    Nady Braidy And Maria Villalva (D.)
    3. Sirtuins and life span extension
    Shin-Hae Lee and Kyung-Jin Min
    4. Sirtuins and aging
    Brian J. Morris
    5. Sirtuins in the biology of aging
    Mateusz Wątroba And Dariusz Szukiewicz
    6. Sirtuins as regulators and the regulated molecules of exosomes
    Qing Han, Yirui Cheng, and Weiliang Xia
    7. Sirtuins in aging, age-related pathologies and their association with circadian rhythm
    Sankarathi Balaiya
    8. Sirtuins, mitochondria, and the melatonergic pathway in Alzheimer’s disease
    G. Anderson and M. Maes
    9. Sirtuins, melatonin, and the relevancevof circadian oscillators
    Rüdiger Hardeland
    10. Epigenetic role of sirtuins in neurodegenerative brain disorders
    Archita Khanna, Anamika, and Surendra Kumar Trigun
    11. Sirtuins and stem cell maintenance, proliferation, and differentiation
    Ryan A. Denu and Peiman Hematti
    12. Sirtuins in mechanistic target of rapamycin complex 1 signaling
    J. Burillo, P. Marqués, B. Jiménez, C. González-Blanco, M. Benito, and C. Guillén
    13. Free-radical redox timer, sirtuins and aging: from chemistry of free radicals to systems theory of reliability
    Vitaly K. Koltover and Tatjana A. Skipa
    14. Sirtuins, mitochondria, and exercise in health and disease
    Anibh M. Das and Partha Dabke

    Section II: Sirtuins, cardiovascular disease and end-organ disease
    15. Scope to develop sirtuins modulators as a therapy to attenuate cardiac complications
    Bugga Paramesha and Sanjay K. Banerjee
    16. Role of sirtuins in cardiovascular diseases
    Venkatraman Ravi, Sneha Mishra, and Nagalingam Ravi Sundaresan
    17. Targeting sirtuins to modulate energy metabolism in heart disease
    Tsunehisa Yamamoto and Ken Shinmura
    18. Sirtuin 1 mediates hepatoprotective effects of resveratrol-like compounds in experimental liver injury
    Hassan Farghali, Mighty Kgalalelo Kemelo, and Nikolina Kutinová Canová
    19. Sirtuins as key players in aging and kidney dysfunction
    Luca Perico and Ariela Benigni
    20. Role of sirtuins in liver diseases
    D. Ezhilarasan and M. Najimi
    22. Vitagenes in avian biology: protective functions of sirtuins
    Peter F. Surai, Ivan I. Kochish, and Vladimir I. Fisinin
    23. Sirtuins in hematopoiesis and blood malignancies
    Berta N. Vazquez, Irene Fernández-Duran, and Alejandro Vaquero

Product details

  • No. of pages: 420
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: February 25, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780128141199
  • Paperback ISBN: 9780128141182

About the Editor

Kenneth Maiese

Kenneth Maiese
Kenneth Maiese, MD, is an internationally recognized physician-scientist whose investigations are designed to translate basic science into successful therapeutic treatments. He maintains therapeutic and scientific expertise in multiple medical disciplines and has been fortunate to receive recognition with outstanding teaching and investigator awards, election to America’s Top Physicians and The Best of U.S. Physicians, recipient of Albert Nelson Marquis Lifetime Achievement Award, and elected as an America’s Health Insurance Plans (AHIP) Executive Leadership Fellow. His work has received the distinction of “High Impact Research and Potential Public Health Benefit” by the National Institutes of Health. As an internationally recognized physician researcher and “C-suite” healthcare leader, he has extensive experience in academic medicine, healthcare delivery, business development, managed care, biotechnology, and drug development holding positions as member and advisor for the National Institutes of Health Biotechnology and Venture Capital Development, National Institutes of Health Innovation Network, Chief Medical Officer, tenured Professor and Chair and Chief of Service of the Department of Neurology and Neurosciences of Rutgers University, Global Head of Translational Medicine and External Innovation, Board Member of the Cancer Institute of New Jersey, Steering Committee Member for the Foundation for the National Institutes of Health, tenured Professor in Neurology, Anatomy & Cell Biology, Molecular Medicine, the Barbara Ann Karmanos Cancer Institute, and the National Institute of Health Center at Wayne State University, and Founding Editor and Editor-in-Chief of multiple highly successful international journals.

Affiliations and Expertise

Biotechnology and Venture Capital Development, Office of Translational Alliances and Coordination, National Heart, Lung, and Blood Institute; Cellular and Molecular Signaling, New York, NY, United States

Ratings and Reviews

Write a review

There are currently no reviews for "Sirtuin Biology in Medicine"