Table of Contents




Chapter 1. Silicon Carbide Materials for Biomedical Applications

1.1. Introduction

1.2. Silicon Carbide—Materials Overview

1.3. Silicon Carbide Material Growth and Processing

1.4. Silicon Carbide as a Biomedical Material

1.5. Summary

Chapter 2. SiC Films and Coatings

2.1. Introduction

2.2. SiC CVD Introduction

2.3. Amorphous Silicon Carbide, a Sic

2.4. Polycrystalline SiC Films

2.5. Single-Crystalline SiC Films

2.6. 3C-SiC Heteroepitaxial Growth on Novel Substrates

2.7. Summary

Chapter 3. Multifunctional SiC Surfaces

3.1. Introduction

3.2. Surface Terminations

3.3. Organic Surface Modification via Self-Assembly Techniques

3.4. Polymer Brushes

3.5. Increased Cell Proliferation on SiC-Modified Surfaces

3.6. Conclusion

Chapter 4. SiC In Vitro Biocompatibility

4.1. Introduction

4.2. Cell Cultures on Single-Crystal SiC Surfaces

4.3. Influence of Surface Properties on Cell Adhesion and Proliferation

4.4. Cleaning of SiC Surfaces for Bioapplications: RCA versus Piranha

4.5. Summary

Chapter 5. Hemocompatibility Assessment of 3C-SiC for Cardiovascular Applications

5.1. Introduction

5.2. Biocompatibility of Materials

5.3. Platelet Adhesion and Activation

5.4. Protein Adsorption to Surfaces

5.5. Microvascular Endothelial Cell Proliferation on Semiconductor Substrates

5.6. Conclusion

Chapter 6. Biocompatibility of SiC for Neurological Applications

6.1. Introduction

6.2. The Basic Central Nervous System

6.3. In Vitro Foreign Material and Living Cell Surface Interaction

6.4. Mouse Primary Cortical Neurons on 3C-SiC

6.5. In Vivo Neuronal Tissue Reaction to Cubic Silicon Carbide



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Elsevier Science
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About the editor

Stephen Saddow

Dr. Saddow’s research interests are to develop wide-bandgap semiconductor materials for high-field and high-power device applications. His most recent work has focused on the use of SiC for Bio, Nano and MEMS applications. He is a visiting professor in Sicily where he conducts analysis and growth studies of 3C-SiC on Si substrates at the Istituto per la Microelettronica e Microsistemi - Consiglio nazionale delle ricerche (IMM-CNR), Catania, Sicily (IT). His ultimate research objective is to develop smart sensors for harsh environments and biomedical applications based on wide band gap semiconductor materials. He is a senior member of the IEEE and has over 100 publications on SiC materials and devices, with nearly half in archived journals.

Affiliations and Expertise

Dept. of Electrical Engineering, College of Engineering and Dept. of Molecular Pharmacology and Physiology, College of Medicine, University of South Florida, Tampa, Florida, USA