Silicon Carbide Biotechnology

1st Edition

A Biocompatible Semiconductor for Advanced Biomedical Devices and Applications

Print ISBN: 9780128103548
eBook ISBN: 9780123859075
Imprint: Elsevier Science
Published Date: 28th November 2011
Page Count: 495
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Silicon Carbide (SiC) is a wide-band-gap semiconductor biocompatible material that has the potential to revolutionize advanced biomedical applications. SiC devices offer higher power densities and lower energy losses, enabling lighter, more compact and higher efficiency products for biocompatible and long-term in vivo applications ranging from heart stent coatings and bone implant scaffolds to neurological implants and sensors.

The main problem facing the medical community today is the lack of biocompatible materials that are also capable of electronic operation. Such devices are currently implemented using silicon technology, which either has to be hermetically sealed so it cannot interact with the body or the material is only stable in vivo for short periods of time.

For long term use (permanent implanted devices such as glucose sensors, brain-machine-interface devices, smart bone and organ implants) a more robust material that the body does not recognize and reject as a foreign (i.e., not organic) material is needed. Silicon Carbide has been proven to be just such a material and will open up a whole new host of fields by allowing the development of advanced biomedical devices never before possible for long-term use in vivo.

This book provides not only the materials and biomedical engineering communities with a seminal reference book on SiC that they can use to further develop the technology, but to also provide a technology resource for medical doctors and practitioners who are hungry to identify and implement advanced engineering solutions to their everyday medical problems that currently lack long term, cost effective solutions.

Table of Contents




Chapter 1. Silicon Carbide Materials for Biomedical Applications

1.1. Introduction

1.2. Silicon Carbide—Materials Overview

1.3. Silicon Carbide Material Growth and Processing

1.4. Silicon Carbide as a Biomedical Material

1.5. Summary

Chapter 2. SiC Films and Coatings

2.1. Introduction

2.2. SiC CVD Introduction

2.3. Amorphous Silicon Carbide, a Sic

2.4. Polycrystalline SiC Films

2.5. Single-Crystalline SiC Films

2.6. 3C-SiC Heteroepitaxial Growth on Novel Substrates

2.7. Summary

Chapter 3. Multifunctional SiC Surfaces

3.1. Introduction

3.2. Surface Terminations

3.3. Organic Surface Modification via Self-Assembly Techniques

3.4. Polymer Brushes

3.5. Increased Cell Proliferation on SiC-Modified Surfaces

3.6. Conclusion

Chapter 4. SiC In Vitro Biocompatibility

4.1. Introduction

4.2. Cell Cultures on Single-Crystal SiC Surfaces

4.3. Influence of Surface Properties on Cell Adhesion and Proliferation

4.4. Cleaning of SiC Surfaces for Bioapplications: RCA versus Piranha

4.5. Summary

Chapter 5. Hemocompatibility Assessment of 3C-SiC for Cardiovascular Applications

5.1. Introduction

5.2. Biocompatibility of Materials

5.3. Platelet Adhesion and Activation

5.4. Protein Adsorption to Surfaces

5.5. Microvascular Endothelial Cell Proliferation on Semiconductor Substrates

5.6. Conclusion

Chapter 6. Biocompatibility of SiC for Neurological Applications

6.1. Introduction

6.2. The Basic Central Nervous System

6.3. In Vitro Foreign Material and Living Cell Surface Interaction

6.4. Mouse Primary Cortical Neurons on 3C-SiC

6.5. In Vivo Neuronal Tissue Reaction to Cubic Silicon Carbide



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