Under the supervision of the series editors, an international team of expert authors have gathered together the latest information on adverse drug effects from the international literature. In addition to describing new reports of adverse drug effects, the authors have subjected those reports to critical analysis, setting them into context in terms of clinical relevance and importance, and cross-referring to previous reports where necessary. New adverse effects are reported and evaluated and previously reported adverse effects are re-evaluated in the light of the most recent information. A special feature is the reviews, in which selected adverse effects are discussed in depth. The use of the book is enhanced by three separate indexes, allowing the reader to enter the text by drug name, adverse effect name, or drug interaction.

Table of Contents

Contributors. In memoriam. List of Special Reviews. How to use this book. Essay: Databases, privacy, and confidentiality - effect of proposed new legislation on pharmacoepidemiology and drug safety monitoring (R.D. Mann). Central nervous system stimulants and drugs that suppress appetite (R.P. Sequeira). Antidepressant drugs (A.H. Young, P.J. Cowen). Lithium (M. Schou). Drugs of abuse (E. Wong, J.K. Patel, A.I. Green). Hypnotics and sedatives (T.C. Jerram). Antipsychotic drugs (D. Capellà, A. Figueras). Anticonvulsant drugs (E. Perucca). Opioid analgesics and narcotic antagonists (A.H. Ghodse, R.E. Edwards). Antipyretic analgesics (A. Iorio, G. Agnelli). Anti-inflammatory analgesics and drugs used in gout (A. Del Favero). General anesthetics and therapeutic gases (Y. Guédès, D. Carlhant). Local anesthetics (J.K. Aronson). Neuromuscular blocking agents and skeletal muscle relaxants (F.J. Richardson, S. Agoston). Drugs affecting autonomic functions or the extrapyramidal system (M. Schachter). Dermatologic drugs, topical drugs and cosmetics (A.C. de Groot). Antihistamines (L. Turner, V. Harris). Positive notropic drugs and drugs used in dysrhythmias (J.K. Aronson). bgr;-adrenoceptor antagonists and antianginal drugs (A.P. Maggioni, M.G. Franzosi, R. Latini). Drugs acting on the cerebral and peripheral circulation (R. Verhaeghe). antihypertensive drugs (F. Zannad). Diuretic drugs (G.T.McInnes). Metals (G.B. van der Voet, F.A. de Wolff). Metal antagonists (R.H.B. Meyboom, I.A. Jaffe). Antiseptic drugs and disinfectants (P. Magee). Penicillins, cephalosporins and other &bgr;-lactam antibiotics (T. Midtvedt). Miscellaneous antibacterial drugs (T. Midtvedt, D. Greenwood). Antifungal drugs (V.K. Lephakhin, A.V. Astakhova). Antiprotozoal drugs (M. Pirmohamed, P.A. Winstanley). Antiviral drugs (P. Reiss, M.D. de Jong). Drugs used in tuberculosis and leprosy (A. Noble, C.J. Ellis). Anthelminthics (A.G.C. B


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Elsevier Science
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