Sex Differences in Neurology and Psychiatry

Sex Differences in Neurology and Psychiatry

1st Edition - September 30, 2020

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  • Editors: Rupert Lanzenberger, Georg S. Kranz, Ivanka Savic
  • eBook ISBN: 9780444641243
  • Hardcover ISBN: 9780444641236

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Sex Differences in Neurology and Psychiatry, Volume 175, addresses this important issue by viewing major neurological and psychiatric conditions through the lens of sexual dimorphism, providing an entirely novel approach to understanding vulnerability factors, as well as potential new treatment strategies in several common neuropsychiatric disorders. The handbook comprises four major sections: (1) Introduction to sex differences in neuroanatomy and neurophysiology, (2) Description of the impact of genetic, epigenetic, sex hormonal and other environmental effects on cerebral sex dimorphism, (3) Review of sex differences in neurologic disorders, and (4) Review of sex differences in psychiatric disorders.

Key Features

  • Explores sex differences in human neuroanatomy and neurophysiology
  • Offers a pathway toward a gender-specific treatment of neurologic and psychiatric disorders
  • Provides an overview of the genetics of sex hormones, human brain structure, and function, as well as the epigenetics, environment and social context


Fellows, residents, and practicing clinicians in neurology and psychiatry; clinical researchers and graduate students in neuroscience

Table of Contents

  • Section I. Sex Differences in Neuroanatomy and Neurophysiology
    1. Structural differences between male and female brains
    2. Beyond sex differences and a male-female continuum: mosaic brains in a multidimensional space
    3. Brain development
    4. HPA axis, stress
    5. Spatial skills
    6. Gender differences in language are small but matter for disorders
    7. Sex differences in cognition and aging and the influence of sex hormones
    8. Sex and the serotonin system
    9. Sex and the dopaminergic system:  Insights from addiction studies
    10. Sex and the noradrenergic system

    Section II. Genes, Hormones, and Epigenetic Mechanisms
    11. Genetics of sex differences in neuroanatomy and function
    12. Sex hormones and human brain function
    13. Environmental epigenetics of sex differences in the brain

    Section III. Sex Differences in Neurologic Disorders
    14. Brain structural and neuroendocrine basis of sex differences in epilepsy 
    15. Neuroinflammation
    16. Sex difference in Alzheimer Disease: an updated, balanced and emerging perspective on differing vulnerabilities
    17. Sex differences in movement disorders
    18. Autism spectrum disorder
    19. Sex differences in stroke

    Section IV. Sex Differences in Psychiatric Disorders
    20. Schizophrenia spectrum and other psychotic disorders
    21. Sex differences in stress-related disorders: major depressive disorder, bipolar disorder and posttraumatic stress disorder
    22. The role of sex and gender in anxiety disorders: being scared ‘like a girl’?
    23. Obsessive-compulsive and related disorders
    24. Feeding and eating disorders
    25. Sex differences in antisocial and aggressive disorders that onset in childhood and persist into adulthood
    26. Addiction among women and sexual minority groups

    Section V. Gender Medicine: Towards a Gender-Specific Treatment of Neuropsychiatric Disorders
    27. Gender medicine: towards a gender-specific treatment of neuropsychiatric disorders

Product details

  • No. of pages: 476
  • Language: English
  • Copyright: © Elsevier 2020
  • Published: September 30, 2020
  • Imprint: Elsevier
  • eBook ISBN: 9780444641243
  • Hardcover ISBN: 9780444641236

About the Series Volume Editors

Rupert Lanzenberger

Dr. Lanzenberger’s research areas include multimodal neuroimaging using PET and fMRI in both psychiatric and neurological patients in comparison to healthy controls, neuroimaging in psychopharmacology, psychoneuroendocrinology including gender medicine, cognitive neuroscience, genetic neuroimaging and experimental neuronuclear medicine. Recently, new multimodal neuroimaging approaches combining pharmacological MRI (phMRI) and PET have been developed. These methodological advancements allow for the evaluation of drug effects in the brain of healthy subjects and patients. By combining molecular and functional imaging information regarding relationship between neurochemical, structural and functional alterations in psychiatric and neurological disorders may be gleaned.

Affiliations and Expertise

NEUROIMAGING LABs (NIL) - PET & MRI & EEG & Chemical Lab, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Wien, Austria

Georg S. Kranz

Georg S. Kranz works at The Hong Kong Polytechnic University, Department of Rehabilitation Sciences, Hong Kong, SAR, China, and at the Medical University of Vienna, Department of Psychiatry and Psychotherapy, Division of General Psychiatry, NEUROIMAGING LABs (NIL) - PET, MRI, EEG, TMS and Chemical Lab, Vienna, Austria.

Affiliations and Expertise

The Hong Kong Polytechnic University, Department of Rehabilitation Sciences, Hong Kong, SAR, China

Ivanka Savic

Dr. Savic’s group is a member of the Stockholm Brain Institute (SBI), a center at the Karolinska Institute for Cognitive and Computational Neuroscience. Her research focuses on the cognitive and emotional decline related to chronic stress as a recognized phenomenon and understanding the underlying mechanisms. They are applying several brain imaging techniques, including PET, to investigate how the human brain is affected by psychosocial stress, and explain the reported emotional and cognitive decline related to stress. The aim is to find biochemical markers of chronic psychosocial stress and develop new treatment strategies.

Affiliations and Expertise

Department of Women's and Children's Health (KBH), Karolinska Universitet and Neurology Clinic, Karolinska Hospital, Stockholm, Sweden

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