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Sex differences in Cardiac Diseases - 1st Edition - ISBN: 9780128193693, 9780128193709

Sex differences in Cardiac Diseases

1st Edition

Pathophysiology, Presentation, Diagnosis and Management

Editors: Niti R. Aggarwal Malissa J. Wood
Paperback ISBN: 9780128193693
eBook ISBN: 9780128193709
Imprint: Elsevier
Published Date: 26th January 2021
Page Count: 720
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Significant biological differences exist between men and women that contribute to sex-specific differences in cardiovascular disease (CVD) risk factors, pathophysiology, presentation, response to therapy, and prognosis. It is essential for clinicians to be cognizant of these sex-specific differences in order to reduce the disparity in diagnosis and management of cardiovascular diseases in both genders.

Sex Differences in Cardiac Disease provides a timely review of the contemporary data on these sex-specific differences in pathophysiology, clinical presentation, diagnostic evaluation, and management of cardiovascular diseases that fills a void for clinicians in practice and training. With contributions from renowned experts in the field and guideline writers, the text provides a state-of-the-art review of each topic encompassing the full spectrum of CVD in men and women. Sex-specific guideline-based recommendations are highlighted when available. Tailored to meet the needs of the busy clinicians and researchers, this text provides concise practical data to care for men and women at risk for or with CVD. The book serves as an essential resource for researchers, cardiologists, obstetricians, gynecologists, internists, family practitioners, nurse practitioners and physician assistants, and respective trainees who treat men and women with CVD.

Key Features

  • Provides a comprehensive state-of-the-art text written by internationally renowned experts in the field of CVD disease, serving as an indispensable resource for clinicians and researchers
  • Enables the reader to understand the sexual dimorphism in the pathophysiology, diagnosis, management, and outcomes of the full spectrum of cardiovascular issues including ischemic heart disease, valvular disorders, arrhythmias, and heart failure
  • Provides a concise evidence-based practical review of medical topics, with key points and eye-catching visual infographics to meet the needs of the busy clinicians, policy makers and researchers.


Researchers interested in clinical sex-differences in cardiovascular disease, Health care professionals who want to better understand and more effectively treat heart disease in women, including clinicians (physicians, physician assistants, nurse practitioners, nurses), cardiologists, obstetricians, gynecologists, internists, family practitioners, nurse practitioners and physician assistants, and respective trainees who treat women with CVD

Table of Contents

Section I. Introduction

1. Introduction: Past, Present, and Future of Heart Disease in Men and Women

Section II: Epidemiology and Prevalence

2. Epidemiology and Prevalence

Section III: Ischemic Heart Disease

3. Prevention of Cardiovascular Disease

4. Acute Coronary Syndrome

5. Spontaneous Coronary Artery Dissection

6. Interventions in Ischemic Heart Disease

7. Stable Ischemic Heart Disease

8. Coronary Microvascular Dysfunction

9. Myocardial Infarction with Nonobstructive Coronary Disease

Section IV: Heart Failure

10. Heart Failure with Reduced Ejection Fraction

11. Heart failure with Preserved Ejection fraction

12. Pulmonary Arterial Hypertension

13. Takotsubo Syndrome

14. Peripartum Cardiomyopathy

Section V: Valvular Heart Disease

15. Valvular Heart Disease

Section VI: Arrhythmias

16. Atrial Fibrillation

17. Ventricular Arrhythmias

18. Role of ICD and CRT

Section VII: Vascular Disease

19. Peripheral Arterial Disease

Section VIII: Congenital Heart Disease

20. Congenital Heart Disease

Section IX: Pregnancy-Related Heart Disease

21. Pregnancy and Cardiovascular Disease

22. Unique Features of Cardiovascular Pharmacology in Pregnancy and Lactation

Section X: Cardiac Disorders Unique or More Specific to Women

23. CardioRheumatology

24. CardioOncology

25. Sex Hormones and Their Impact on Cardiovascular Health

Section XI: Psychological Health in CVD

26. Psychosocial Issues in Cardiovascular Disease

Section XII: Pharmacotherapy Considerations in Men and Women

27. Cardiovascular Medications

Section XIII: Current Challenges, Opportunities and Next Steps for Clinicians

28. Disparity in Care Across the CVD Spectrum

29. Women’s Heart Programs


No. of pages:
© Elsevier 2021
26th January 2021
Paperback ISBN:
eBook ISBN:

About the Editors

Niti R. Aggarwal

Niti R. Aggarwal, MD, FACC, FASNC is a Senior Associate Consultant of Cardiovascular Medicine, an Assistant Professor of Medicine at Mayo Clinic- Rochester, MN and a Fellow of the American College of Cardiology (ACC). She is recognized nationally and internationally for her research and clinical expertise focused on heart disease in women and multimodal cardiac imaging. As a faculty at the Mayo Clinic’s Women Heart Center, she attracts patients from all over the world. A thought-leader in her field, she has authored numerous publications, and serves on the editorial board for the Journal of Nuclear Cardiology, the ACC’s Women in Cardiovascular Disease Committee, and the program committees for multiple annual scientific meetings. She also serves on the ACC’s Solution Set Oversight Committee overseeing curation and dissemination of national scientific guidelines.

Affiliations and Expertise

Senior Associate Consultant, Mayo Clinic, Assistant Professor of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, United States

Malissa J. Wood

Malissa J. Wood, MD, FACC, is an Associate Professor of Medicine at Harvard Medical School where she serves as the Co-director of Massachusetts General Hospital Heart Center Corrigan Women’s Heart Health Program, and the Cathy E. Minehan Chair of Cardiovascular Disease in Women. Dr. Wood is the Principal Director of the Massachusetts General Hospital Spontaneous Coronary Artery Dissection Registry and is a member of Steering Committee of the International Spontaneous Coronary Dissection Registry (iSCAD). Dr. Wood is also the Governor of the Massachusetts American College of Cardiology Chapter. She is the author of numerous manuscripts, chapters and reviews addressing cardiovascular disease in women as well as development of effective approaches designed to address diversity in cardiovascular medicine. Dr. Wood is also the author of two books, Smart at Heart and Thinfluence.

Affiliations and Expertise

Associate Professor of Medicine, Harvard Medical School, Co-director Corrigan Women’s Heart Health Program, Massachusetts General Hospital, Massachusetts General Hospital, Boston, MA

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