Sertoli Cell Biology

1st Edition

Editors: Michael Skinner Michael Griswold Michael Griswold
Hardcover ISBN: 9780126477511
eBook ISBN: 9780080492285
Imprint: Academic Press
Published Date: 15th October 2004
Page Count: 512
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Description

Sertoli cells assist in the production of sperm in the male reproductive system. This book provides a state-of-the-art update on the topic of sertoli cells and male reproduction. It addresses such highly topical areas as stem cells, genomics, and molecular genetics, as well as provides historical information on the discovery of this type of cell, and the pathophysiology of male infertility.

Key Features

  • Presents the state-of-the-art research on topics such as stem cell research, transplantation and genomics
  • Includes contributions from leaders in the field, including several members of the National Academy of Science

Readership

Researchers, investigators and students in the fields of male reproduction, cell and developmental biology, and genomics.

Table of Contents

Introduction. History of the Sertoli Cell Discovery; Perspective on the Function of Sertoli Cells; Structure of the Sertoli Cell. Sertoli Cell Development; Embryonic Sertoli Cell Differentiation; Sertoli Cell Biology in Fish and Amphibians; Sertoli Cell Biology in Seasonal Breeders; Sertoli Cell Function and Gene Expression; Sertoli Cell Gene Expression and Protein Secretion; Secretion of Regulatory Factors; Proteases and Protease Inhibitors; Sertoli Cell Endocrinology and Signal Transduction; FSH Regulation at the Molecular and Cellular Level; Mechanisms of Action and Function Effects; In Vivo FSH Actions; Sertoli Cell Endocrinology and Signal Transduction: Androgen Regulation; Thyroid Hormone Regulation of Sertoli Cell Development; The Transforming Growth Factor â (TGFâ) Superfamily in Sertoli Cell Biology; Sertoli Cell Signal Tansduction (cAMP and JAK); Sertoli Cells Transcriptional Regulation; Transcription Factors in Sertoli Cells; Structure & Regulation of the FSH Receptor Gene; Sex Determination Genes in Sertoli Cells; Cell-Cell Interactions Involving Sertoli Cells; The Role of the Sertoli Cell in Spermatogonial Stem Cell Fate; Sertoli Cell-Somatic Cell Interactions; Sertoli Cell Lines; Sertoli Cell Pathophysiology; Sertoli Cell Toxicants; Conditions Affecting Sertoli Cells. Spermatogonial Stem Cells: Gonocyte Development; Hormones and Spermatogonial Development; Long-Term Cultures of Mammalian Spermatogonia; Transplantation.

Details

No. of pages:
512
Language:
English
Copyright:
© Academic Press 2004
Published:
Imprint:
Academic Press
eBook ISBN:
9780080492285
Hardcover ISBN:
9780126477511

About the Editor

Michael Skinner

Affiliations and Expertise

Washington State University, School of Molecular Bioscience, Center for Reproductive Biology, Pullman, U.S.A.

Michael Griswold

Excerpt from Hartman Award from Society for the Study of Reproduction Carl G. Hartman Award (Supported by a grant from Cook Medical) This award is the most prestigious award conferred by the Society for the Study of Reproduction. Each year, this award recognizes an exemplary research career in reproductive biology. The 2013 recipient of the Carl G. Hartman Award is Michael D. Griswold, Ph.D. Dr. Michael D. Griswold, Regents Professor of Molecular Biosciences at Washington State University (WSU), is world-renowned for his contributions to our understanding of Sertoli cell structure and functions and the crucial role of Vitamin A in spermatogenesis and a loyal member of SSR. Mike received a B.S. in Chemistry and Ph.D. in Biochemistry from the University of Wyoming. He conducted postdoctoral studies with Dr. Philip Cohen at the University of Wisconsin, funded by an NIH Postdoctoral Fellowship, working on amphibian metampophosis, and with Dr. Flauco P. Tocchini-Valentini in Rome, funded by an EMBO Fellowship, on Xenopus RNA. Mike spent a year as an Assistant Professor of Pharmacology at Baylor College of Medicine in Houston. He then spent two years as a Research Associate in the laboratory of Dr. Irving Fritz at the University of Toronto, where he acquired what would become a life-long interest in Sertoli cells. Mike joined the faculty of WSU in 1976 as an Assistant Professor of Biochemistry and Basic Medical Sciences, was promoted to Associate and then full Professor, appointed Chair of the Department of Biochemistry and Biophysics in 1994, Director of the School of Molecular Biosciences in 1999, and Dean of the College of Sciences, a position he held from 2003-2010. Mike became a Regents Professor of Molecular Biosciences in 2008, and in 2011, received the WSU Eminent Faculty Award, the highest faculty honor at WSU. Mike’s research has been continuously funded by the NIH since 1977 (with the same grant “Hormonal Control of the Maturation of Sertoli Cells”),

Affiliations and Expertise

School of Molecular Biosciences, Center for Reproductive Biology, College of Veterinary Medicine, Washington State University, Pullman, WA, U.S.A.

Michael Griswold

Excerpt from Hartman Award from Society for the Study of Reproduction Carl G. Hartman Award (Supported by a grant from Cook Medical) This award is the most prestigious award conferred by the Society for the Study of Reproduction. Each year, this award recognizes an exemplary research career in reproductive biology. The 2013 recipient of the Carl G. Hartman Award is Michael D. Griswold, Ph.D. Dr. Michael D. Griswold, Regents Professor of Molecular Biosciences at Washington State University (WSU), is world-renowned for his contributions to our understanding of Sertoli cell structure and functions and the crucial role of Vitamin A in spermatogenesis and a loyal member of SSR. Mike received a B.S. in Chemistry and Ph.D. in Biochemistry from the University of Wyoming. He conducted postdoctoral studies with Dr. Philip Cohen at the University of Wisconsin, funded by an NIH Postdoctoral Fellowship, working on amphibian metampophosis, and with Dr. Flauco P. Tocchini-Valentini in Rome, funded by an EMBO Fellowship, on Xenopus RNA. Mike spent a year as an Assistant Professor of Pharmacology at Baylor College of Medicine in Houston. He then spent two years as a Research Associate in the laboratory of Dr. Irving Fritz at the University of Toronto, where he acquired what would become a life-long interest in Sertoli cells. Mike joined the faculty of WSU in 1976 as an Assistant Professor of Biochemistry and Basic Medical Sciences, was promoted to Associate and then full Professor, appointed Chair of the Department of Biochemistry and Biophysics in 1994, Director of the School of Molecular Biosciences in 1999, and Dean of the College of Sciences, a position he held from 2003-2010. Mike became a Regents Professor of Molecular Biosciences in 2008, and in 2011, received the WSU Eminent Faculty Award, the highest faculty honor at WSU. Mike’s research has been continuously funded by the NIH since 1977 (with the same grant “Hormonal Control of the Maturation of Sertoli Cells”),

Affiliations and Expertise

School of Molecular Biosciences, Center for Reproductive Biology, College of Veterinary Medicine, Washington State University, Pullman, WA, U.S.A.

Reviews

"5 Stars!...Experienced investigators who are deeply (passionately) interested in the biology of the testis and the biochemical and molecular mechanisms of male reproduction wrote this book. This is an important and valuable contribution to the field that presents state-of-the-art information. It will be a treasured resource and source of inspiration for years to come." --Bruce A Fenderson, Ph.D.(Thomas Jefferson University) in DOODY REVIEWS (March 2005) "This is a well written book filled with cutting edge and up-to-date information by authors eminent within their field." --VETERINARY PATHOLOGY (2005, 42:6)