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SERS for Point-of-care and Clinical Applications
1st Edition - August 12, 2022
Editor: Andrew Fales
Language: English
Paperback ISBN:9780128205488
9 7 8 - 0 - 1 2 - 8 2 0 5 4 8 - 8
eBook ISBN:9780128209103
9 7 8 - 0 - 1 2 - 8 2 0 9 1 0 - 3
SERS for Point-of-care and Clinical Applications focuses on the use of Surface-Enhanced Raman Spectroscopy (also known as Surface-Enhanced Raman Scattering) techniques in clinical…Read more
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SERS for Point-of-care and Clinical Applications focuses on the use of Surface-Enhanced Raman Spectroscopy (also known as Surface-Enhanced Raman Scattering) techniques in clinical and point-of-care settings. Sections provide an overview of SERS biomedical applications, providing in-depth information about point-of-care and clinical applications of SERS using specific examples from current literature. These applications are not always immediately evident to newcomers in the field, as Raman and SERS are often introduced as analytical methods for chemical analysis. This book offers a concise introduction to the biomedical applications of SERS for graduate students, scientists and researchers in all related fields.
Highlights point-of-care applications for SERS
Covers the recent biomedical applications of SERS carried out by leaders in the field
Includes chapters on SERS probes and labels and label-free uses of SERS
Scientists, researchers, and graduate students using Surface-Enhanced Raman Spectroscopy (SERS) in the fields of chemistry, biology, biophotonics, nanotechnology, and physics who are interested applying SERS in clinical and point-of-care settings
Cover image
Title page
Table of Contents
Copyright
Contributors
Editor biography
Chapter 1. Data analysis in SERS diagnostics
Introduction
General data processing workflow
Data preprocessing
Models
Verification of results
Hyperparameter optimization
Concluding remarks
Chapter 2. Label-free SERS techniques in biomedical applications
Introduction
Oncological diseases
Neurological diseases
Infectious diseases
Future challenges and perspectives
Chapter 3. SERS probes and tags for biomedical applications
Introduction
Design considerations
Chapter 4. SERS biosensors for point-of-care infectious disease diagnostics
Development of the iMS nanoprobe for label-free homogenous biosensing
Detection of miRNA biomarkers within biological samples
Multiplexed detection of miRNA biomarkers
Conclusion
Chapter 6. SERS detection of oral and gastrointestinal cancers
Introduction
Oral cancer
Esophageal cancer
Stomach cancer
Intestinal cancer
Concluding remarks
Chapter 7. In vivo imaging with SERS nanoprobes
Introduction
Raman imaging with SERS nanoprobes
In vivo imaging with SERS nanoparticles—multiplexing potential
Biological barriers and opportunities
Passive tumor targeting
Opsonization/sequestration by the mononuclear phagocyte system
Sequestration based on physicochemical properties
Blood–brain barrier
Molecular targeting
Ex vivo SERS-based molecular imaging
In vivo molecular imaging with SERS nanoprobes
Multimodal imaging using SERS nanoprobes
The future of in vivo Raman imaging
Imaging deeper
SERS and endoscopy
Spatially offset optics
Imaging faster
Nanoprobe administration
Conclusion
Index
No. of pages: 256
Language: English
Edition: 1
Published: August 12, 2022
Imprint: Elsevier
Paperback ISBN: 9780128205488
eBook ISBN: 9780128209103
AF
Andrew Fales
Andrew Fales is a Staff Fellow in Biomedical Engineer and works in the Division of Biomedical Physics, Office of Science and Engineering Laboratories at the Center for Devices and Radiological Health, U.S. Food and Drug Administration.
Affiliations and expertise
Staff Fellow, Biomedical Engineer, Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration
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