Serotonin

Serotonin: The Mediator That Spans Evolution provides a comprehensive review of the widespread roles for serotonin in respiratory, cardiovascular and thermoregulatory control, and for growth and development in early life. This important resource highlights serotonin’s role in normal (unstressed) conditions, and in response to a variety of physiological stressors. It focuses on new animal models, comparing and contrasting data from mice and rats. In addition, the book compares and contrasts the physiological effects of brain and blood serotonin systems and includes new data suggesting that the influence of serotonin is in part through the regulation of gene expression.

Finally, it discusses the role of serotonin system dysfunction in a variety of pathophysiological conditions, including sleep apnea, obesity and hypertension, and presents compelling evidence that this dysfunction is involved in Sudden Infant Death Syndrome (SIDS).

• Includes the latest information on new animal models of serotonin system dysfunction
• Explores the wide scope of serotonin’s influence on multiple organ and physiological systems
• Highlights the autonomous functioning of the brain and body serotonin systems
• Provides compelling evidence of serotonin dysfunction in SIDS, a leading cause of death in infancy

Basic and clinical researchers of systems physiology as well as clinicians

BIOPHYSICS OF SEROTONIN
1. Biophysics of Serotonin and the Serotonin1A Receptor: Fluorescence and Dynamics
Amitabha Chattopadhyay
2. Serotonin in plants: origin, function, and implications
Praveen Saxena

ANATOMY
3. The anatomy of the serotonin system　in different model systems: rat fish, flies and C. Elegans
Patricia Gaspar and Christina Lillesaar
4. Serotonin in the endocrine pancreas
Malin Fex
5. Serotonin and platelets
Simone Marianne Schoenwaelder
6. Anatomy of the Serotonin Transporter
Arnauld Belmer, Kate Beecher and Selena E. Bartlett

PHYSIOLOGY IN THE PERIPHERY
7. Cellular regulation of peripheral serotonin
Damien Keating
8. Role of 5-HT in the control of gut motility
Nicholas John Spencer
9. Phenotype of animals deficient in peripheral serotonin
Michael Bader
10. Serotonin and immune system
Luc Maroteaux and Anne Roumier
11. Serotonin and Adipocyte Function
Malin Fex and Karin Stenkula
12. Serotonin and cardiovascular diseases
Luc Maroteaux and Laurent Monassier
13. Involvement of 5-HT in afferent modulation of brainstem circuits regulating cardiovascular homeostasis
Andrew Ramage and Patrick Hosford
14. Regulation of nociceptor signalling by serotonin
Stefan Boehm and Isabella Salzer

PHYSIOLOGY IN THE BRAIN
15. Brain serotonin and energy homeostasis
Yong Xu
16. Serotonin in central cardiovascular control
Paul M. Pilowsky
17. Serotonin receptors and cardiovascular control
Caroline Sevoz-Couche
18. Serotonin receptors as the therapeutic target for central nervous system disorders
Yukihiro Ohno
19. Serotonin and the reconfiguration of the eupneic respiratory pattern
Daniel Zoccal
20. Life without brain serotonin: phenotype of animals deficient in central serotonin synthesis
Valentina Mosienko and Natalia Alenina