This book provides a unique and timely multidisciplinary synthesis of our current knowledge of the anatomy, pharmacology, physiology and behavioral data of the serotonin (5-HT)-dopamine (DA) interactions. Central serotonergic and dopaminergic systems play a critical role in the regulation of normal and abnormal behaviors. Moreover, recent evidence suggests that the dysfunction of the DA and 5-HT neurotransmitter systems contribute to various mental disorders including depression, schizophrenia, drug addiction and Parkinson’s disease. This extremely important topic is of wide interest within the scientific community, with relevance not only to specialists but also to general practitioners and students. The book provides a valuable contribution to the debate on new pharmacological approaches for several psychopathological states, with contributions from expert neuroscientists and pharmacologists who comprehensively survey the most significant currently active areas of dopamine/serotonin interactions.

Key Features

* Provides an understanding of the interaction between Serotonin and Dopamine. * Appeals equally to specialists, general practitioners, students and researchers. * Contributes to the debate on new pharmacological approaches to several psychopathological states * Gives a comprehensive anatomical description plus the physiology and pharmacology of dopaminergic and serotonergic systems * Singles out neuropsychiatric and suggests new therapeutic approaches.


Clinical Psychiatrists, Primary Care Physicians, and specialists in the behavioral health community. Also Graduate students and researchers involved with serotonergic and dopaminergic systems. Possibly Pharmaceutical companies who market dopaminergic and serotonergic drugs

Table of Contents

1. SEROTONIN-DOPAMINE INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM 1. Serotonin-Dopamine Interaction: an overview E. Esposito, V. Di Matteo and G. Di Giovanni (Santa Maria Imbaro, Chieti and Palermo, Italy) 2. Serotonin control of central dopaminergic function: focus on in vivo microdialysis studies V. Di Matteo, G. Di Giovanni, M. Pierucci and E. Esposito (Santa Maria Imbaro, Chieti and Palermo, Italy) 3. Serotonin-Dopamine Interaction: electrophysiological evidence G. Di Giovanni, V. Di Matteo, M. Pierucci and E. Esposito (Palermo and Santa Maria Imbaro, Chieti, Italy 4. Functional genetic polymorphisms in serotonin and dopamine gene systems and their significance in behavioural disorders U.M. D’Souza and I.W. Craig (London, UK) 2. SEROTONIN-DOPAMINE INTERACTIONS IN SCHIZOPHRENIA 5. Distribution of 5-HT and DA receptors in primate prefrontal cortex: implications for pathophysiology and treatment J. de Almeida, J.M. Palacios and G. Mengod (Barcelona, Spain) 6. Alterations of dopamine and serotonin transmission in schizophrenia G. Remington (Toronto, ON, Canada) 7. Serotonin and dopamine interactions in psychosis prevention N.M. Richtand and R.K. McNamara (Cincinnati, OH, USA) 8. Role of serotonin and dopamine receptor binding in antipsychotic efficacy N.M. Richtand, J.A. Welge, A.D. Logue, P.E. Keck, Jr., S.M. Strakowski and R.K. McNamara (Cincinnati, OH, USA) 9. In vivo actions of atypical antipsychotic drug on serotonergic and dopaminergic systems H.Y. Meltzer and M. Huang (Nashville, TN, USA) 10. Neuropharmacology of second-generation antipsychotic drugs: a


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© 2008
Elsevier Science
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About the editors

Giuseppe Di Giovanni

Affiliations and Expertise

Dipartimento di Medicina Sperimentale, Sezione di Fisiologia Umana, ‘‘G. Pagano’’, Universita` di Palermo, Italy

Vincenzo Di Matteo

Affiliations and Expertise

Istituto di Ricerche Farmacologiche Mario Negri, Italy

Ennio Esposito

Affiliations and Expertise

Istituto di Ricerche Farmacologiche Mario Negri, Italy