Serotonin and Behavior

Serotonin and Behavior

1st Edition - January 1, 1973

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  • Editor: Jack Barchas
  • eBook ISBN: 9780323143660

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Description

Serotonin and Behavior contains the proceedings of the 1972 symposium on the behavioral effects of changes in brain serotonin, held at Stanford University in California. The papers explore the role of serotonin in behavior as well as the key biochemical and pharmacological issues involved in behavioral studies of severe psychiatric disorders in both humans and animals. The book is organized into eight sections comprised of 65 chapters, with topics ranging from the fundamental biochemistry and pharmacology of the enzymes synthesizing serotonin, particularly, tryptophan hydroxylase and its inhibitors, to the physiology and pharmacology of serotonin. Some papers discuss the link between the telencephalic content of serotonin and pain sensitivity. Other papers focus on the effects of altering serotonin on neurons in the central nervous system. There are chapters that explain the effects of altering serotonin on animal behavior, the relationship between serotonin and sleep, the use of high doses of probenecid to estimate central serotonin turnover in affective disorders and addicts, the behavioral and metabolic effects of L-tryptophan in unipolar depressed patients taking methadone, and amygdala unit activity as a reflection of functional changes in brain serotonergic neurons. Biochemists, pharmacologists, psychiatrists, psychologists, and anyone interested in psychopharmacology will find this book extremely useful.

Table of Contents


  • Contributors

    Preclinical Psychopharmacology Research Review Committee

    Preface

    Welcoming Statement

    Session 1. Biochemistry and Pharmacology: Tryptophan Hydroxylase and Inhibitors of Tryptophan Hydroxylase

    Introduction

    Does the Total Turnover of Brain 5-HT Reflect the Functional Activity of 5-HT in Brain?

    Metabolism of p-Chlorophenylalanine and the Molecular Aspects of Its Action

    Assays and Properties of Tryptophan 5-Hydroxylase

    Comparative Studies on the Effect of Psrachlorophenylalanine on Hydroxylation of Tryptophan in Pineal and Brain of Rat

    Physiologic and Drug-Induced Regulation of Serotonin Synthesis

    Tryptophan Hydroxylase Inhibitors Other than PCPA

    Some Drug Effects on the Functions of the Two Measurable Forms of Tryptophan-5-Hydroxylase: Influence on Hydroxylation and Uptake of Substrate

    Discussion

    Session 2. Physiology and Pharmacology: Localization, Uptake, and Metabolism of Serotonin

    Introduction

    Localization and Transport of Serotonin

    Serotonin Uptake Systems in Brain Tissue

    The Role of Serotonin /V-Acetyltransferase in the Adrenergic

    Regulation of Indole Metabolism in the Pineal Gland

    Control of Brain 5-HT Content by Dietary Carbohydrates

    The Normal Occurrence of Tryptamine in Brain and Its Conversion to N-Methyl and N-Dimethyltryptamine in Vitro and in Vivo

    The Role of Brain Serotonin in the Pharmacologic Effects of the Methyl Xanthines

    Suppression of Brain Serotonin Synthesis and Metabolism by Benzodiazepine Minor Tranquilizers

    Discussion

    Session 3. Physiology and Pharmacology: Depletion of Serotonin

    Introduction

    Serotonin and Convulsions

    Brain Serotonin and the Pituitary-Adrenal System

    Relationship between Telencephalic Content of Serotonin and Pain Sensitivity

    Recent Studies on the Mechanism of Action of Chlorinated Amphetamines

    An Approach to the Assay of Serotonin Using Gas-Liquid Chromatography and Mass Fragmentography—the Pineal Gland as a Model System

    Effects of 5,6-Dihydroxytryptamine on Brain Monoamine Neurons in the Rat

    Discussion

    Session 4. Neurophysiology: Effects of Altering Serotonin on Central Nervous System Neurons

    Introduction

    Behavioral Pharmacology of p-Chlorophenylalanine (PCPA)

    The Physiology and Pharmacology of Serotonin Mediated Synapses

    Direct and Indirect Actions of LSD, Serotonin and Related Compounds on Serotonin-Containing Neurons

    5-HT-Containing Neurons: Unit Activity in Behaving Cats

    Amygdala Unit Activity as a Reflection of Functional Changes in Brain Serotonergic Neurons

    Serotonergic Receptors in the Central Nervous System

    The Role of Hypothalamic Serotonin in Thermoregulation

    Discussion

    Session 5. Animal Behavioral Studies: Behavioral Effects of Altering Serotonin in Animals

    Introduction

    Effects of Behavioral Manipulations upon Brain Serotonin and Dopamine

    Effects of PCPA on Fighting Behavior and Habituation of Startle Response in Rats

    Biochemical and Behavioral Changes in Rats with Experimental Phenylketonuria

    Effects of Serotonin Depletion on Behavior in Monkeys

    Effects of Parachlorophenylalanine on the Behavior of Monkeys

    Changes in Brain Serotonin Level and Male Sexual Behavior

    Discussion

    Session 6. Animal Behavioral Studies—Sleep: The Relation of Serotonin to Sleep

    Introduction

    Serotonin and Sleep in the Cat

    The Effect of flarachlorophenylalanine on Sleep in the Rat: Some Implications for the Serotonin-Sleep Hypothesis

    The Effect of the Chronic Administration of Parachlorophenylalanine (PCPA) on Sleep Parameters in the Cat

    Cat Brain Serotonin Content during Sleep and Wakefulness

    Monoaminergic Systems in the Brain and Their Role in the Sleep States

    5-HTP and the Syndrome of Intention or Action Myoclonus as a Sequel to Hypoxic Encephalopathy

    Discussion

    Session 7. Human Behavior: Tests for Serotonin Utilization in Humans and Effects of Precursor Loading in Various Disorders

    Introduction

    Monoamine Metabolism in Depression: Clinical Application of the Probenecid Test

    The Use of Probenecid in High Doses for the Estimation of Central Serotonin Turnover in Affective Illness and Addicts on Methadone

    Precursor Loading Strategies

    Cerebrospinal Fluid Levels of 5-Hydroxyindoleacetic Acid in Psychiatric Disorders: A Critical Assessment

    5-Hydroxytryptophan and Chronic Schizophrenia—A Preliminary Study

    Oral 5-Hydroxytryptophan Effects on Sleep

    Discussion

    Session 8. Human Behavior: Tests for Serotonin Utilization in Humans and Effects of Precursor Loading in Various Disorders

    Introduction

    Role of Serotonin in Affective Disorders

    Behavioral and Metabolic Effects of L-Tryptophan in Unipolar Depressed Patients

    Balance, Permission, and Discrimination among Amines: A Theoretical Consideration of the Actions of L-Tryptophan in Disorders of Movements and Affect

    Clinical Studies of L-5-Hydroxytryptophan in Depression

    Discussion

    Summary

    References

    Abbreviations

    Subject Index


Product details

  • No. of pages: 670
  • Language: English
  • Copyright: © Academic Press 1973
  • Published: January 1, 1973
  • Imprint: Academic Press
  • eBook ISBN: 9780323143660

About the Editor

Jack Barchas

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