Separation Methods in Drug Synthesis and Purification, Volume 1

1st Edition

Authors: Valko
Hardcover ISBN: 9780444500076
eBook ISBN: 9780080541099
Imprint: Elsevier Science
Published Date: 13th October 2000
Page Count: 612
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Table of Contents

Editor's Preface. Series Editor's Preface. List of Contributors. Comparison of various modes and phase systems for analytical HPLC (P. Jandera). Fundamentals of HPLC. Chromatographic column and column packing particles. Separation modes in HPLC. Method development and optimisation of conditions in isocratic HPLC. Development of gradient-elution separations. Acknowledgements. References. Fast generic HPLC methods (I.M. Mutton). Introduction. Theory. Strategy for production of fast gradients. Fast gradients in practice. References. Application of standard methods in capillary electrophoresis for drug analysis (K. Altria). Introduction to capillary electrophoresis. Analysis of pharmaceuticals by CE. Low-pH buffer for analysis of basic drugs. High-pH buffer for analysis of acidic drugs. Micellar electrokinetic chromatography (MEKC) for neutral and=or charged drugs. Microemulsion electrokinetic chromatography (MEEKC) for neutral and=or charged drugs. Indirect UV detection method for analysis of inorganic anions. Indirect UV detection method for analysis of simple organic acids. Indirect UV detection method for analysis of metal ions. Non-aqueous CE for analysis of acidic and basic drugs. Benefits of adopting standard CE methods. References. Capillary electrochromatography (CEC) (C.J. Paterson, R.J. Boughtflower). Introduction. Basic principles of capillary electrochromatography. Mobile phase composition. Stationary phases used in CEC. Operational characteristics of CEC. Gradient and pressure-assisted (pseudo) CEC. Conclusions. Glossary of symbols. References. Coupled chromatography-mass spectrometry techniques for the analysis of combinatorial libraries (S. Lane). Introduction. LC=MS analysis of high-throughput parallel synthesis libraries. Example for monitoring the rehearsal phase of the synthesis of a solid-ph


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