Sensing of Deadly Toxic Chemical Warfare Agents, Nerve Agent Simulants, and their Toxicological Aspects

Sensing of Deadly Toxic Chemical Warfare Agents, Nerve Agent Simulants, and their Toxicological Aspects

1st Edition - September 15, 2022

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  • Editors: Sangita Das, Sabu Thomas, Partha Pratim Das
  • Paperback ISBN: 9780323905534
  • eBook ISBN: 9780323906722

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Sensing of Deadly Toxic Chemical Warfare Agents, Nerve Agent Simulants, and their Toxicological Aspects provides a general overview of the development and performance of different novel molecular frameworks as potent vehicles for sensing Chemical Weapons (CWs). The chapters are contributed by leading researchers in the areas of materials science, medical science, chemical science, and nanotechnology from industries, academics, government and private research institutions across the globe. It covers cover topics such as inorganic nanocomposites, hyperbranched polymers, and graphene heterojunctions for effective sensing of CW agents. This book is a highly valuable reference source for graduates, post-graduates, and research scholars primarily in the fields of materials science, medicinal chemistry, organic chemistry, and nanoscience and nanotechnology. In addition, almost all analytical techniques will be discussed, making this a first-rate reference for professors, students, and scientists in many industries.

Key Features

  • Provides an efficient, reliable, and highly versatile approach for the synthesis of different molecular systems suitable for diversity-oriented strategies, structure-activity studies and molecular tailoring for the sensing of chemical warfare agents
  • Goes into depth on new binary organogels, discrete carbon nanomaterials (CNMs) and molecularly imprinted polymers (MIPs) and has endowed electrochemical chemosensors (ECCSs) with high selectivity and sensitivity towards the detection of chemical warfare agent
  • Highlights in detail the detection of CWs by composite optical waveguide sensors, and describes disposable biofilm biosensors for sensitive detection of biotoxicity in water with treatment of nerve agent poisoning


University professors, researchers, students and scientists primarily working in the field of organic and applied chemistry, materials science, environmental sciences, medical science, and nanotechnology

Table of Contents

  • Introduction

    1. Chemical warfare agents: An outlook on past and present technologies
    2. Metal-Organic-Framework Composite based rapid Self-Detoxifying Smart Textile Filters for Chemical-Warfare Agents
    3. Plasmonic Nanosensors for Chemical Warfare Agents
    4. Quantification of DCP (diethylchlorophosphate) for the recognition of organophosphorous chemical warfare agents
    5. Advances in gold nanoparticles for optical detection of nerve agents
    6. Functionalized two-dimensional photonic crystals for the detection of chemical warfare agents
    7. Optically advanced Carbon dots for sensing of harmful toxins
    8. Nano Materials in Organophosphate Sensing: Present and Future Perspective
    9. Smart hydrogel nanostructured sensor for detection of organophosphorus chemical warfare nerve agents
    10. Graphene based nanocomposites for detection of chemical messengers in nervous system
    11. Aptamer based approaches for sensing harmful synthetic and natural toxins
    12. MOFs derived nanoarchitectures for the detection of phenolic compounds
    13. Sensing of Phenol and Chlorophenols using Carbon Nanotubes Modified Glassy Carbon Electrode
    14. Nanotubes tethered laccase biosensor for sensing of chlorophenol substances
    15.  Use of organic compounds as Medical Products for the therapeutic treatment exposed to CW's agents
    16. An assessment of Chemical Warfare Agents in soils: Detection, Distribution and Ecotoxicology
    17. Assessment of the impact of chemical weapons disposal in the ocean according to international conventions
    18. Chemical Warfare: Unprecedented Environmental Threat
    19. Clinical Symptoms of Chemical Warfare Agents Toxicity including Mustards, Halogenated Oximes, Arsenicals, Toxins Poisoning
    20. Advances targeted therapy in toxicology and medical treatment of chemical warfare nerve agents
    21. The reversible inhibitors of acetylcholinestrerase as pre-treatment options against nerve agents intoxications
    22. Paraoxonase 1 as a potential prophylactic countermeasure against nerve agent poisoning
    23. Potential Alternative treatments and Routes of Administrations: Chemical Warfare Agents Poisoning
    24. Therapeutic Treatment of Nerve Agent toxicity
    25. Carbon-nanomaterial modified molecularly imprinted polymers for the sensing of Organophosphorus simulants
    26. Carbon-nanomaterial modified recognition platforms for the sensing of organophosphorous simulants
    27. Graphene-based nanocomposites for electrochemical sensing of Organophosphate triesters
    28. Synthesis of simulants of nerve agents for the assays of AChE inhibition
    29. Toxicological and Pharmacological Aspects of Organophosphorus Nerve Agents

Product details

  • No. of pages: 764
  • Language: English
  • Copyright: © Elsevier 2022
  • Published: September 15, 2022
  • Imprint: Elsevier
  • Paperback ISBN: 9780323905534
  • eBook ISBN: 9780323906722

About the Editors

Sangita Das

Dr. Sangita Das is working as Newton International Fellow at Durham University, England, United Kingdom. She also works as a visiting professor in the Department of Energy Science in Mahatma Gandhi University, Kerala, India. She received her B. Sc. degree with honors in chemistry in 2008 from the University of Calcutta, Kolkata, West Bengal, India. She obtained her M. Sc. degree in chemistry with organic specialization in 2010 from the same university. She had qualified the all India (CSIR–JRF) NET, and then she joined “The Goswami Group,” Department of Chemistry, IIEST for her doctoral work under the supervision of Prof. Shyamaprosad Goswami. She got Ph.D. in 2016. Her areas of research interest include molecular recognition; design of fluorescence chemosensors; and characterization of fluorescence probe (detection of metal ions, anions, reactive oxygen species, nerve gas, and other environmentally hazardous species, etc.); aggregation-induced emission dyes and solid-state emitters, and synthesis of compounds with antidiabetic activity. She is now working as a Newton International Fellow in the United Kingdom. Her current research activities include the development of compounds as HDAC inhibitors, experimental and theoretical investigations of electronic structure of transition metal complexes with redox noninnocent ligands, and computational chemistry (DFT, TDDFT calculations).

Affiliations and Expertise

Royal Society Newton International Fellow, Department of Chemistry, Durham University, Durham, United Kingdom Post-doctoral research fellow, Durham University, England, UK

Sabu Thomas

Prof. Sabu Thomas is a renowned professor who is serving as the Vice-Chancellor of Mahatma Gandhi University, Kerala, India. He is also a full professor of Polymer Science and Engineering at the School of Chemical Sciences, a role which he has held since 1998. He was previously Pro-Vice Chancellor of Mahatma Gandhi University 2017-2018, Director of School of Chemical Science during 2010-2013, Hon. Director of International & Inter-University Centre for Nanoscience and Nanotechnology 2009-2015 and 2016-17. In 2015, Prof. Thomas received his first Docteur Honoris Causa from University of Souther Brittany in Lorient, France. In 2016, he received his second Doctorate honoris causa from University of Lorraine, France. He was awarded the Fellow of the Royal Society of Chemistry, London, FRSC in 2012. He received the Bronze Medal of the Chemical Research Society of India and the MRSI Medal of the Material Research Society of India in 2013. He was the recipient of Fulbright-Nehru International Education Administrators Award 2017. He also received TRiLA Academician of the year 2018 award. Prof. Thomas has published more than 1000 publications, and more than 100 books.

Affiliations and Expertise

Full Professor, International and Inter University Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, Kottayam, Kerala, India

Partha Pratim Das

Dr. Partha Pratim Das is presently working as a postdoctoral researcher in Seoul National University, South Korea. He previously worked in the Institute of High-Pressure Mineral Physics and Chemistry, Yonsei University, Seoul, South Korea, as a postdoctoral researcher. He has completed both the B.Sc. (2008) and M.Sc. (2010) in chemistry from Calcutta University, India. He has received Ph.D. in science (chemistry) in 2016 from Jadavpur University, India. His working laboratories during Ph.D. are CSIR-CGCRI, Kolkata, and CSIR-NCL, Pune, India. His research area is focused on nanotechnology, synthesis, and structure–properties correlation studies of different multifunctional nanomaterials under various conditions for mainly clean and sustainable energy and environmental applications. He has published several high-impact papers in peer-reviewed journals. Moreover, his research works have been acclaimed in many national and international conferences and journal societies.

Affiliations and Expertise

Postdoctoral researcher, Institute of High-Pressure Mineral Physics and Chemistry, Yonsei University, Seoul, South Korea

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