Semiconducting Silicon Nanowires for Biomedical Applications

Semiconducting Silicon Nanowires for Biomedical Applications

1st Edition - February 4, 2014

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  • Editor: Jeffery Coffer
  • Hardcover ISBN: 9780857097668
  • eBook ISBN: 9780857097712

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Description

Biomedical applications have benefited greatly from the increasing interest and research into semiconducting silicon nanowires. Semiconducting Silicon Nanowires for Biomedical Applications reviews the fabrication, properties, and applications of this emerging material. The book begins by reviewing the basics, as well as the growth, characterization, biocompatibility, and surface modification, of semiconducting silicon nanowires. It goes on to focus on silicon nanowires for tissue engineering and delivery applications, including cellular binding and internalization, orthopedic tissue scaffolds, mediated differentiation of stem cells, and silicon nanoneedles for drug delivery. Finally, it highlights the use of silicon nanowires for detection and sensing. These chapters explore the fabrication and use of semiconducting silicon nanowire arrays for high-throughput screening in the biosciences, neural cell pinning on surfaces, and probe-free platforms for biosensing. Semiconducting Silicon Nanowires for Biomedical Applications is a comprehensive resource for biomaterials scientists who are focused on biosensors, drug delivery, and tissue engineering, and researchers and developers in industry and academia who are concerned with nanoscale biomaterials, in particular electronically-responsive biomaterials.

Key Features

  • Reviews the growth, characterization, biocompatibility, and surface modification of semiconducting silicon nanowires
  • Describes silicon nanowires for tissue engineering and delivery applications, including cellular binding and internalization, orthopedic tissue scaffolds, mediated differentiation of stem cells, and silicon nanoneedles for drug delivery
  • Highlights the use of silicon nanowires for detection and sensing

Readership

Scientists in the fields of chemistry, chemical engineering, bioengineering, biological sciences, materials scientists, physicists, etc.; Researchers in academia and industry that are interested in nanoscience

Table of Contents

  • Contributor contact details

    Woodhead Publishing Series in Biomaterials

    Foreword

    Part I: Introduction to silicon nanowires for biomedical applications

    1. Overview of semiconducting silicon nanowires for biomedical applications

    Abstract:

    1.1 Introduction

    1.2 Origins of silicon nanowires

    1.3 The structure of this book

    1.4 Conclusion

    1.5 References

    2. Growth and characterization of semiconducting silicon nanowires for biomedical applications

    Abstract:

    2.1 Introduction

    2.2 Synthesis methods for silicon nanowires (SiNWs)

    2.3 Characterization methods

    2.4 Synthesis of semiconductor SiNWs by the chemical vapor deposition (CVD) method

    2.5 Conclusion

    2.6 Future trends

    2.7 Sources of further information and advice

    2.8 References

    3. Surface modification of semiconducting silicon nanowires for biosensing applications

    Abstract:

    3.1 Introduction

    3.2 Methods for fabricating silicon nanowires (SiNWs)

    3.3 Chemical activation/passivation of SiNWs

    3.4 Modification of native oxide layer

    3.5 Modification of hydrogen-terminated silicon nanowires (H-SiNW)

    3.6 Site-specific immobilization strategy of biomolecules on SiNWs

    3.7 Control of non-specific interactions

    3.8 Conclusion

    References

    4. Biocompatibility of semiconducting silicon nanowires

    Abstract:

    4.1 Introduction

    4.2 In vitro biocompatibility of silicon nanowires (SiNWs)

    4.3 In vivo biocompatibility of SiNWs

    4.4 Methodology issues

    4.5 Future trends

    4.6 Conclusion

    4.7 References

    Part II: Silicon nanowires for tissue engineering and delivery applications

    5. Functional semiconducting silicon nanowires for cellular binding and internalization

    Abstract:

    5.1 Motivation: developing a nano-bio model system for rational design in nanomedicine

    5.2 Methods: non-linear optical characterization and surface functionalization of silicon nanowires (SiNWs)

    5.3 Applications: in vivo imaging and in vitro cellular interaction of functional SiNWs

    5.4 Conclusions and future trends

    5.5 References

    6. Functional semiconducting silicon nanowires and their composites as orthopedic tissue scaffolds

    Abstract:

    6.1 Introduction

    6.2 Nanowire surface etching processes to induce biomineralization

    6.3 Nanowire surface functionalization strategies to induce biomineralization

    6.4 Construction of silicon nanowire (SiNW)-polymer scaffolds: mimicking trabecular bone

    6.5 The role of SiNW orientation in cellular attachment, proliferation and differentiation in the nanocomposite

    6.6 Conclusions and future trends

    6.7 Acknowledgement

    6.8 References

    7. Mediated differentiation of stem cells by engineered semiconducting silicon nanowires

    Abstract:

    7.1 Introduction

    7.2 Methods for fabricating silicon nanowires (SiNWs)

    7.3 Regulated differentiation for human mesenchymal stem cells (hMSCs)

    7.4 SiNWs fabricated by the electroless metal deposition (EMD) method and their controllable spring constants

    7.5 Mediated differentiation of stem cells by engineered SiNWs

    7.6 Conclusion

    7.7 Future trends

    7.8 Acknowledgements

    7.9 References

    8. Silicon nanoneedles for drug delivery

    Abstract:

    8.1 Introduction

    8.2 Strategies for nanoneedle fabrication

    8.3 Drug loading of nanoneedles and release patterns

    8.4 Drug delivery using nanoneedles

    8.5 Toxicity of nanoneedles

    8.6 Overview of nanoneedle applications

    8.7 Conclusion

    8.8 References

    Part III: Silicon nanowires for detection and sensing

    9. Semiconducting silicon nanowire array fabrication for high throughput screening in the biosciences

    Abstract:

    9.1 Introduction

    9.2 Fabrication of silicon nanowire (SiNW) field effect transistor (FET) arrays for high throughput screening (HTS) in the biosciences

    9.3 Surface modification of SiNW FETs for HTS in the biosciences

    9.4 Integration of SiNW FETs with microfluidic devices for HTS in real-time measurements

    9.5 Examples/applications of SiNW FETs

    9.6 Conclusion

    9.7 Future trends

    9.8 References

    10. Neural cell pinning on surfaces by semiconducting silicon nanowire arrays

    Abstract:

    10.1 Introduction

    10.2 Toward control of neuronal topography and axo-dendritic polarity

    10.3 Neuron networks on top of silicon nanowires (SiNWs)

    10.4 Future trends

    10.5 Conclusion

    10.6 References

    10.7 Appendix: experimental section

    11. Semiconducting silicon nanowires and nanowire composites for biosensing and therapy

    Abstract:

    11.1 Introduction

    11.2 Fabrication of silicon nanowires (SiNWs) and two-dimensional SiNW architectures

    11.3 SiNWs for biosensing applications

    11.4 Fabrication of SiNW-polymer composite systems

    11.5 Biomedical applications of SiNW-polymer composites

    11.6 Conclusions and future trends

    11.7 References

    12. Probe-free semiconducting silicon nanowire platforms for biosensing

    Abstract:

    12.1 Introduction

    12.2 Silicon nanowire (SiNW) biosensors

    12.3 Probe layers

    12.4 Integrated sample delivery

    12.5 Electrical biasing and signal measurement

    12.6 Examples/applications of SiNW biosensor platforms

    12.7 Conclusions

    12.8 Future trends

    12.9 References

    Index

Product details

  • No. of pages: 296
  • Language: English
  • Copyright: © Woodhead Publishing 2014
  • Published: February 4, 2014
  • Imprint: Woodhead Publishing
  • Hardcover ISBN: 9780857097668
  • eBook ISBN: 9780857097712

About the Editor

Jeffery Coffer

Jeffery L. Coffer is a Professor in the Department of Chemistry and Biochemistry of Texas Christian University where he has been a member of the faculty since 1990. With a principal focus on silicon nanostructures for drug delivery and “smart” biomedical applications, his research group has investigated a variety of therapeutic targets using these platforms, including structures with anticancer, antibacterial, and anti-inflammatory relevance. Composites comprised of nanostructured Si and biocompatible polymers with utility for tissue engineering are also of interest. Coffer has authored more than 165 refereed publications, three patents, numerous book chapters, and received multiple awards, including the Chancellor’s Award for Distinguished Achievement as a Teacher–Scholar and the Wilfred T. Doherty Award for Research (American Chemical Society).

Affiliations and Expertise

Professor, Texas Christian University, TX, USA

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