
Selenium and Selenoproteins in Cancer
Description
Key Features
- Provides information on cancer research and prevention
- Offers outstanding and original reviews on a range of cancer research topics, with this volume focusing on the role of selenium and selenoproteins in cancer prevention
- Serves as an indispensable reference for researchers and students alike
Readership
Researchers and students in the basic and clinical sciences of cancer biology and oncology, plus related areas in genetics, immunology, pharmacology, cell biology, and molecular biology
Table of Contents
1. The Epidemiology of Selenium and Human Cancer
Marco Vinceti, Tommaso Filippini, Silvia Cilloni, and Catherine M. Crespi
2. Selenoproteins in Tumorigenesis and Cancer Progression
Sarah P. Short and Christopher S. Williams
3. Selenoproteins and Metastasis
Michael P. Marciel and Peter R. Hoffmann
4. Selenium-Dependent Glutathione Peroxidases During Tumor Development
Anna P. Kipp
5. Targeting the Selenoprotein Thioredoxin Reductase 1 for Anticancer Therapy
Elias S.J. Arnér
6. The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium
Bastihalli T. Diwakar, Arvind M. Korwar, Robert F. Paulson, and K. Sandeep Prabhu
7. Selenium and Breast Cancer Risk: Focus on Cellular and Molecular Mechanisms
Camile C. Fontelles and Thomas P. Ong
8. Selenium and Epigenetics in Cancer: Focus on DNA Methylation
Ewa Jabłonska and Edyta Reszka
9. Selenium and Cancer Stem Cells
Giuseppe Murdolo, Desirée Bartolini, Cristina Tortoioli, Marta Piroddi, Pierangelo Torquato, and Francesco Galli
10. elenocompounds in Cancer Therapy: An Overview
Desirée Bartolini, Luca Sancineto, Andreza Fabro de Bem, Kenneth D. Tew, Claudio Santi, Rafael Radi, Pierangelo Toquato, and Francesco Galli
Product details
- No. of pages: 316
- Language: English
- Copyright: © Academic Press 2017
- Published: October 19, 2017
- Imprint: Academic Press
- Hardcover ISBN: 9780128120163
- eBook ISBN: 9780128120170
About the Serial Volume Editor
Kenneth Tew

The Tew laboratory maintains an interest in using redox pathways as a platform to develop therapeutic strategies through drug discovery/development and biomarker identification. We interrogate how reactive oxygen and nitrogen species (ROS/RNS) impact cancer cells and develop novel drugs that impact on glutathione based pathways. Our research efforts have been integral to studies that have identified glutathione S-transferases (GST) as important in drug resistance, catalytic detoxification and as arbiters of kinase-mediated cell signaling events. In addition, we have been instrumental in defining how GSTP contributes to the process by which cells respond to ROS by selective addition of glutathione to specific protein clusters, so called S-glutathionylation. Each of these research areas has had broad impact on a number of cancer disciplines. Moreover, we have also been seminally involved in the Phase I to III clinical testing of three oncology drugs, Telcyta, Telintra and NOV-002. Other ongoing translational efforts have produced two ongoing clinical trials to measure the effectiveness of serum S-glutathionylated serine proteinase inhibitors as possible biomarkers for exposure to hydrogen peroxide mouthwashes and radiation.
Affiliations and Expertise
About the Editor
Francesco Galli
Affiliations and Expertise
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