COVID-19 Update: We are currently shipping orders daily. However, due to transit disruptions in some geographies, deliveries may be delayed. To provide all customers with timely access to content, we are offering 50% off Science and Technology Print & eBook bundle options. Terms & conditions.
Selected Topics in the History of Biochemistry - 1st Edition - ISBN: 9780444805072, 9780444598202

Selected Topics in the History of Biochemistry, Volume 35

1st Edition

Personal Recollections, Part I

Editor: G. Semenza
eBook ISBN: 9780444598202
Imprint: Elsevier Science
Published Date: 1st January 1983
Sales tax will be calculated at check-out Price includes VAT/GST
Price includes VAT/GST

Institutional Subscription

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Table of Contents

Selected Topics in the History of Biochemistry Personal Recollections. I.

General Preface

Preface to Volume 35

Contributors to this volume

List of Plates


Chapter 1. The Isolation of Cori-Ester, "The Saint Louis Gateway" to a First Approach of a Dynamic Formulation of Macromolecular Biosynthesis

The Coris in Post-World War I Europe

The Coris in the U.S.A.

Research at Washington University, School of Medicine

The Discovery of Cori-Ester and the Concept of Phosphorolysis

Polysaccharide Synthesis in Vitro

Isolation of Crystalline Muscle Phosphorylase Catalyzing Amylose Synthesis

Phosphorylases α and β and their Role in Metabolic Regulation

Regulation of Phosphorylase in Resting and Contracting Muscle

1947 Nobel Prize for Physiology and Medicine

The Effect of Hormones on Carbohydrate Metabolism in Vitro

Personal Data from Later Years



Chapter 2. The Discovery of Sugar Nucleotides

The Discovery of Sugar Nucleotides

1948-49 Glucose Diphosphate

1950 UDPG

1951 UDP-Galactose

1952 UDP-Acetylglucosamine

1953-55 UDP-Glucuronic Acid

1953 Biosynthesis of Disaccarides

Final Remarks


Chapter 3. The Road to Ion-Coupled Membrane Processes

Washington College



A Year with Fritz Lipmann

A Decade with Carl Cori


Metabolite Regulation of Glucolysis

A Regulatory Site for Glucose-6-Phosphate

Membrane Transport

Toward the Mechanism of Glucose Active Transport

Fall of the Phosphorylation-Dephosphorylation Hypothesis


A Group Transfer Reaction with Glucose is Not the Mechanism

Energy Transduction is at the Brush-Border Membrane

The Idea of Na+-Coupling

The First Model, Convective-Coupling

Coupling by Co-Transport




Chapter 4. From Fructose to Fructose-2,6-Bisphosphate with a Detour through Lysosomes and Glycogen

As a Medical Student, I Participated in the Rediscovery Of Glucagon

How the Agglutination of Microsomes at pH5 Opened the Way to Several Discoveries

The Metabolism of Fructose in the Liver

The ATP-Magnesium Complex

The Publication of the Sorbitol Pathway was Delayed by Thermodynamica Considerations

A Call from a Paediatrician Introduced Me Into Glycogen Storage Disease

The First Lysosomal Disease was Discovered Because of the Complexity of the Reaction Catalysed by Amylo-l,6-Glucosidase

The Concept of Inborn Lysosomal Disease is a Logical Deduction Made from My Observations in Type II Glycogenosis

It Took 10 Years to have the Concept of Inborn Lysosomal Diseases Accepted

The Hepatic Threshold to Glucose

Fructose Revisited with a Glance to Primary Gout

The Futile Cycles and the Discovery of Fructose-2,6-Bisphosphate

The Other Face of the Story


Chapter 5. Sir Frederick Gowland Hopkins (1861-1947)

Character and Outlook

Education and Early Employment

Establishment of Biochemistry in Cambridge


Purines and Pterins



Muscular Contraction


Some Biographical Points


Chapter 6. A Short Autobiography

The War 1917-1919


Concept of Active Centers as a Possible Explanation of Enzyme Action

The Effects of Malonic Acid and Substituted Malonic Acids on Bacterial Dehydrogenases


Rothamsted Experimental Station




Chapter 7. A Biochemist's Approach to Autopharmacology


Early influences

Medical Studies and the Role of Biochemistry

The Status of Biochemistry as an Academic Subject

Biochemistry in Dahlem and Heidelberg

England in the Nineteen-Twenties and -Thirties

Humoral Transmission and the Catecholamines

Amine oxidases

Biogenesis of Adrenaline

Intracellular Localization of the Catecholamines

On Methods

Conclusions: The Amine-Forming Cells



Chapter 8. The Svedberg and Arne Tiselius. The Early Development of Modern Protein Chemistry at Uppsala

The Svedberg

The Optical Centrifuge

The First Ultracentrifuge

The High-Speed Oil-Turbine Ultracentrifuge

Svedberg's Molecular Weight Hypothesis

Arne Tiselius

Further Development of the High-Speed Ultracentrifuge

Further Protein Studies

Serum and Serum Proteins

The Separation Cell

Ultracentrifuges to Go Abroad

The Later Periods In Svedberg's Life

Chromatography of Colourless Substances

The Two Personalities

In Retrospect


Chapter 9. Survey of a French Biochemist's Life

My Grandparents and my Parents

High School and University Studies

First Contact with Biochemistry and Research

My Return to Lyon and World War II

Life in Marseille (Act I)


Chemistry and Physiochemistry of Lipids

Construction of Our First Institue at the University

Life in Marseille (Act II)

Interlude in Paris

Creation of a Second Research Center (C.N.R.S.)

Proteolytic Enzymes and Zymogens (Second Period)

Bovine Procarboxypeptidase

The Lipase-Colipase System (Second Period)


Chapter 10. From α-Corticotropin through β-Lipotropin to β-Endorphin

Hormone Research Laboratory

Chemical Messengers

α-Corticotropin (ACTH)

Peptide Synthesis



Concluding Remarks



Chapter 11. A.N. Bach, Founder of the Soviet School of Biochemistry

Short Biography



Chapter 12. Sergei E. Severin: Life and Scientific Activity

An Autobiographical Review


Name Index


Selected Topics in the History of Biochemistry: Personal Recollections, I presents selected topics in the history of biochemistry based on the authors' personal recollections. These topics range from the isolation of Cori ester and the discovery of sugar nucleotides to the work of Frederick Gowland Hopkins (1861-1947). Ion-coupled membrane processes are also discussed, along with fructose and fructose-2,6-bisphosphateas well as lysosomes and glycogen.

Comprised of 12 chapters, this volume begins with the discovery of Cori ester and the concept of phosphorolysis before turning to the discovery of sugar nucleotides and research on ion-coupled membrane processes. The reader is then introduced to studies of fructose, fructose-2,6-bisphosphate, lysosomes, and glycogen; the contributions of Frederick Gowland Hopkins in biochemistry; and a short autobiography of Juda Hirsch Quastel, with emphasis on his research work on the concept of active centers as a possible explanation of enzyme action and his investigation of the effects of malonic acid and substituted malonic acids on bacterial dehydrogenases. The remaining chapters focus on a biochemist's approach to autopharmacology; the early development of modern protein chemistry in Uppsala, Sweden; and the biographies of two Russian scientists, A. N. Bach and Sergei E. Severin.

This monograph will be of interest to students, practitioners, and researchers in the field of biochemistry.


© Elsevier Science 1983
1st January 1983
Elsevier Science
eBook ISBN:

Ratings and Reviews

About the Editor

G. Semenza

Affiliations and Expertise

Swiss Institute of Technology, ETH-Zentrum, Zürich, Switzerland