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Seldin and Giebisch's The Kidney - 4th Edition - ISBN: 9780120884889, 9780080559506

Seldin and Giebisch's The Kidney

4th Edition

Physiology & Pathophysiology 1-2

Editors: Robert Alpern Steven Hebert
eBook ISBN: 9780080559506
Hardcover ISBN: 9780120884889
Imprint: Academic Press
Published Date: 1st October 2007
Page Count: 2928
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A classic nephrology reference for over 20 years, Seldin & Giebisch’s The Kidney, is the acknowledged authority on renal physiology and pathophysiology. The fourth edition follows the changed focus of nephrology research to the study of how individual molecules work together to affect cellular and organ function, emphasizing the mechanisms of disease. With over 40 new chapters and over 1000 illustrations, this edition offers the most in-depth discussion anywhere of the physiologic and pathophysiologic processes of renal disease. Comprehensive, authoritative coverage progresses from molecular biology and cell physiology to clinical issues regarding renal function and dysfunction. If you research the development of normal renal function or the mechanisms underlying renal disease, Seldin & Giebisch’s The Kidney is your number one source for information.

Key Features

  • Offers the most comprehensive coverage of fluid and electrolyte regulation and dysregulation in 51 completely revised chapters unlike Brenner & Rector's The Kidney which devotes only 7 chapters to this topic.
    * Includes 3 sections, 31 chapters, devoted to regulation and disorders of acid-base homeostasis, and epithelial and nonepithelial transport regulation. Brenner & Rector's only devotes 5 chapters to these topics.
    * Previous three editions edited by Donald Seldin and Gerhard Giebisch, world renowned names in nephrology. The title for the fourth edition has been changed to reflect their considerable work on previous editions and they have also written the forward for this edition.
    * Over 20 million adults over age 20 have chronic kidney disease with the number of people diagnosed doubling each decade making it America's ninth leading cause of death.


Academic and medical librarians in kidney physiology, nephrology and renal medicine. This will also serve as an excellent reference for clinical nephrologists and trainees, graduate students, researchers, academic clinicians and any pharmaceutical company working on renal medications.

Table of Contents

Epithelial and Nonepithelial Transport and Regulation
General Principles of Epithelial and Nonepithelial Transport
Transport Regulation
Structural and Functional Organization of the Kidney
Structural Organization
Functional Organization
Renal Differentiation and Growth
Fluid and Electrolyte Regulation and Dysregulation
Regulation and Disorders of Sodium Chloride Homeostasis
Regulation and Disorders of Water Homeostasis
Regulation and Disorders of Potassium Homeostasis
Regulation and Disorders of Acid-Base Homeostasis
Regulation and Disorders of Magnesium Homeostasis
Regulation and Disorders of Calcium Homeostasis
Regulation and Disorders of Phosphate Homeostasis
Regulation and Disorders of Organic Solute Homeostasis
Regulation and Disorders of Proteins and Macromolecules
Pathophysiology of Renal Diease
Clinical Presentation of Renal Derangements
Mechanisms of Renal Injury
Progression of Renal Disease
Physiological Considerations in the Management of Renal Disease

For full table of contents please see the link on the right below the blue bar "Look inside".


No. of pages:
© Academic Press 2007
1st October 2007
Academic Press
eBook ISBN:
Hardcover ISBN:

About the Editors

Robert Alpern

Robert Alpern

Dr. Alpern has performed research in the area of epithelial physiology, focusing on the mechanisms and regulation of acid transport. He received his MD degree from the University of Chicago and then trained in Internal Medicine at Columbia Presbyterian. Following postdoctoral training in the Cardiovascular Research Institute at the University of California, San Francisco, Alpern joined the faculty at UCSF, then moved to the University of Texas Southwestern Medical School as Chief of Nephrology and later Dean of the medical school. He is now Dean of Yale School of Medicine and Ensign Professor.

Affiliations and Expertise

Dean and Ensign Professor of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA

Steven Hebert

Steven Hebert

Dr. Steven C. Hebert is the C.N.H. Long Professor of Physiology and Medicine at Yale University School of Medicine in New Haven, Connecticut, USA, and Chair of the Department of Cellular and Molecular Physiology. Dr Hebert’s research interests include salt and mineral metabolism, especially calcium and magnesium homeostasis, the renal handling of potassium, the diuretic-sensitive Na/K/Cl cotransporters and epithelial salt and water transport. Dr Hebert cloned and characterized the calcium-sensing receptor, the renal potassium secretory channel, ROMK, the thiazide-sensitive Na-Cl cotransporter and the loop diuretic-sensitive Na-K-2Cl cotransporter. Dr Hebert has served on the faculty of the University of Alabama, the University of Texas, Harvard Medical School-Brigham & Women’s Hospital and Vanderbilt University Medical School. Dr. Hebert was elected to the American Society for Clinical Investigation, the Association of American Physicians and the National Academy of Sciences of the USA. Amongst several awards, Dr Hebert has received the Carl W. Gottschalk Award from the American Physiological Society and the Homer W. Smith Award from the American Society of Nephrology and New York Heart Association and the A.N. Richard’s Award of the International Society of Nephrology. Dr Hebert has been editor, or on the editorial boards, of numerous physiology, membrane biology and renal-related journals. He is the author of over 260 peer-reviewed papers, reviews, book chapters and books.

Affiliations and Expertise

Yale University School of Medicine, New Haven, Connecticut, USA


Praise for the Previous Edition:
"This is an excellent in-depth compilation of all aspects of renal physiology in health and disease, presented in well-balanced in chapters with high-quality figures and ample references…This book clearly represents an excellent, useful, usable, and (in view of recent rapid scientific progress) needed update of the previous edition and will have a prominent place on my bookshelf as well as those of many others in the field." – 4 Stars!
-- Jens W. Goebel, MD, University of Kentucky, for Doody’s Revie

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