Segmented Negative Strand Viruses

Segmented Negative Strand Viruses

Arenaviruses, Bunyaviruses, and Orthomyxoviruses

1st Edition - January 28, 1984

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  • Editor: Richard W. Compans
  • eBook ISBN: 9781483273372

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Segmented Negative Strand Viruses: Arenaviruses, Bunyaviruses, and Orthomyxoviruses is a collection of proceedings presented at the 5th International Symposium on Negative Strand Viruses, held at Hilton Head, South Carolina, on September 11-17, 1983. The papers focus on three virus families with segmented negative RNA genomes: arenaviruses, bunyaviruses, and orthomyxoviruses. Emphasis is placed on the viruses' replication strategies, gene organization, and biochemical and biological properties. Comprised of 56 chapters, this volume begins with an introduction to the genome structure, transcription, and genetics of arenaviruses, bunyaviruses, and orthomyxoviruses. The next section is devoted to these viruses' gene expression, protein synthesis, and protein modification. Eukaryotic expression of cloned complementary DNA coding for influenza is considered, along with the functional expression and mutational analysis of influenza virus surface glycoproteins. Subsequent chapters explore viral proteins via antigenic and functional analyses; the biology and immunochemistry of the African arenaviruses Lassa and Mopeia; and the use of avian-human reassortant influenza A viruses as live vaccine viruses in humans. This book will be of interest to investigators, microbiologists, and molecular and cell biologists in fields such as molecular biology, genetics, viral immunology, infectious diseases, and vaccine development.

Table of Contents

  • Contributors


    Contents of Nonsegmented Negative Strand Viruses

    Genome Structure, Transcription, and Genetics

    Coding Analyses of Bunyavirus RNA Species

    Molecular Cloning of the Bunyamwera Virus Genome

    Hybrid Selection of Viral mRNA using cDNA Clones of Inkoo Virus M Gene

    Rift Valley Fever Virus Intracellular RNA: A Functional Analysis

    Transcription of the S RNA Segment of Germiston Bunyavirus

    The S Segment of Bunyaviruses Codes for Two Complementary RNAs

    Restriction of Subunit Reassortment in the Bunyaviridae

    Genetic Analyses of Pichinde and LCM Arenaviruses: Evidence for a Unique Organization for Pichinde S RNA

    Studies on the Molecular Biology of Lymphocytic Choriomeningitis Virus

    Sequence Rearrangements in Influenza Virus RNA and Ribonucleoprotein Structure

    Molecular Topography of the Influenza Virus P Protein Complex during Capped RNA-Primed Messenger RNA Synthesis

    In Vivo Transcription and Translation of Defective-Interfering Particle-Specific RNAs of Influenza Virus

    Mutants Obtained following Undiluted Passage of an Influenza A (Fowl Plague) Virus

    Genetic Stability of A/Ann Arbor/6/60 Cold-Mutant (Temperature-Sensitive) Live Influenza Vaccine Strains

    Gene Expression, Protein Synthesis, and Protein Modification

    Subgenomic RNA of Arenavirus Pichinde and its Implication in Regulation of Viral Gene Expression in Productive Infection and Persistence

    Biochemical Characterization of Hantaan Virus

    Eukaryotic Expression of Cloned cDNA Coding for Influenza Viral Glycoproteins using an SV40 Vector: Use of Recombinant DNA Mutants to Study Structure-Function Relationships

    Studies on the Second Protein Encoded by the Neuraminidase Gene of Influenza B Virus

    Functional Expression and Mutational Analysis of Influenza Virus Surface Glycoproteins

    The Nonstructural Gene Segment of Influenza A Virus: Expression of NS1 Protein in Mammalian Cells; Analysis of a Deletion Mutant

    Production of a Subunit Vaccine for Rift Valley Fever Virus

    Persistent Expression of Influenza Virus Nucleoprotein in Recombinant DNA-Transfected Mouse Cells

    Expression of Influenza Virus Subgenomic Virion RNAs in Infected Cells

    Transport of Viral Glycoprotein and its Modulation by Monensin

    Interfering with Glycoprotein Processing in Influenza and Sindbis Virus-Infected Cells

    Viral Proteins: Antigenic and Functional Analyses

    Antigenic and Structural Studies on the Glycoproteins of Lymphocytic Choriomeningitis Virus

    Comparative Analysis of Lassa and Lassa-Like Arenavirus Isolates from Africa

    Neutralization of Arenaviruses: Reaction of Tacaribe Virus and Variants with Monoclonal Antibodies

    Antigenic Sites on the Gl Glycoprotein of La Crosse Virus that are Involved in Neutralization

    Influenza Virus Neuraminidase: Structure and Variation

    Pleiotropic Effects of a Single Amino Acid Change on Antigenicity and Biologic Function of Swine Influenza Virus Hemagglutinin Mutants

    Selection of Receptor Variants from Human and Avian Influenza Isolates with the H3 Hemagglutinin

    Antigenic Alterations of the Influenza Virus Hemagglutinin during the Infectious Cycle

    Antigenic Drift of the H1 Subtype Hemagglutinin from 1977 to 1980

    The Binding Sites to Monoclonal Antibodies on A/USSR/90/77 (H1N1) Hemagglutinin

    Structure of the Cleavage Site of Hemagglutinins of Pathogenic and Nonpathogenic H7 Influenza Viruses

    An Influenza Virus Mutant Whose Lesion Results in Temperature-Sensitive Hemagglutination

    The Carbohydrates of the Hemagglutinin of Influenza Virus

    Heterogeneity of the Membrane (M1) Protein of Influenza Virus

    Antigenic Characterization of Influenza A Matrix Protein with Monoclonal Antibodies

    Evolutionary Conservation of Influenza Nucleoprotein Genes in Host Species

    Virus-Specific Polypeptides in Cells Infected with Influenza C, Dhori, and Thogoto Viruses


    Mechanism of Persistent LCMV Infection in Mice: Role of LCMV Variants in Suppression of LCMV-Specific Cytotoxic T-Cell Response and Maintenance of the Carrier State

    The African Arenaviruses Lassa and Mopeia: Biological and Immunochemical Comparisons

    Replication of Bunyaviruses in a Xenopus Laevis Cell Line

    Interaction of Neutralized Influenza Virus with Avian and Mammalian Cells

    Restricted Mobility of Influenza Hemagglutinin on HeLa Cell Plasma Membranes

    Reassembly of Membranous Particles with Influenza Virus Hemagglutinin and Restoration of Biological and Immunological Activities

    Incorporation of M Protein of Influenza Virus into Liposomes: Further Characterization of Liposomal Structures

    In Vitro and in Vivo Properties of an Influenza A Host Range Virus

    Self-Inactivation of Influenza A Virus and Autolysis of the Virus-Infected Cells

    Use of Avian-Human Reassortant Influenza A Viruses as Live Vaccine Viruses in Man


Product details

  • No. of pages: 440
  • Language: English
  • Copyright: © Academic Press 1984
  • Published: January 28, 1984
  • Imprint: Academic Press
  • eBook ISBN: 9781483273372

About the Editor

Richard W. Compans

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