
Second Generation Cell and Gene-Based Therapies
Biological Advances, Clinical Outcomes and Strategies for Capitalisation
Description
Key Features
- Helps readers learn about the most current trends in cell-based therapy, their overall effectiveness from a clinical prospective, and how the industry is moving therapies forward for capitalization
- "Perspectives" section at the end of each chapter summarizes key learnings, hypotheses, and objectives highlighted and combines scientific and business insights
- Edited and authored by scientists representing both basic and clinical research and industry, presenting a complete story of the current state and future promise of cellular therapies
Readership
Table of Contents
PART 1 Science
1. Innovation S- Curves in Living Drugs Development and Their Commercialisation
2. Development and Deployment of Gene Therapies: An ADA- SCID Case Study
3. Therapeutic Potential of Cells of the Immune System
4. T Cell Engineering and the Rise of CAR- T Cell Therapies
5. Harnessing Natural Killer Cells’ Killing Function in Cancer
6. Pluripotent Stem Cell–Derived Islet Replacement Therapy for Diabetes
7. Harnessing in Silico Technologies to Develop and Augment Second- Generation Cell- Based Therapies
8. Second Generation Genome Editing Technologies in Drug Discovery
9. The Next Wave: Tissue Replacement and Organ Replacement
10. Combining Stem Cells and Materials for Nerve Tissue RegenerationPART 2 Translation
11. Gene Therapy Clinical Trials: Past, Present and Future
12. CAR-T Cell Clinical Trials Experience – Past, Present and Future
13. T Cell Receptor Engineered T Cell Therapy in Oncology
14. Cytotherapy Clinical Trials in Genetic Disorders of the Blood and Options for ReimbursementPART 3 The Next Frontier
15.Mesenchymal Stromal Cell Therapies – The Next Frontiers
16. Regenerative Medicine and Ageing: Is Senescence Reprogrammable?
17. Deciphering the Systems Architecture of the Brain Using Molecular Can Openers
18. Harnessing the Therapeutic Potential of Dendritic Cells
19. Brief Overview of Chimeric Antigen Receptor–Mediated Immunotherapy for Glioblastoma Multiforme
20. Combination Therapies in Solid Tumour OncologyPART 4 Perspectives
21. Gene- Editing Technologies in Adoptive T Cell Therapy for Cancer: An Ethical Analysis
22. Decisions in the Development Lifecycle of Cell and Gene Therapies
23 CAR- T: From Concepts to Products – Now What?
24. Strategic Alliances in Cytotherapies and Gene Therapies: Funding the New Wave of Cell Therapeutics
25. The Role of Governments in the Commercial Emergence of Radical Innovation: The Case of the United Kingdom
26. Patenting Trends in Chimeric Antigen Receptor Technologies
27. Reimbursement and Payment Models for Therapies With Transformative and Curative Intent
28. Commercialising CAR- T Therapies: The Evolution of a Revolution
29. Will You Move the Needle of Medicine?
Product details
- No. of pages: 846
- Language: English
- Copyright: © Academic Press 2020
- Published: February 7, 2020
- Imprint: Academic Press
- Hardcover ISBN: 9780128120347
- eBook ISBN: 9780128120330
About the Editors
Alain Vertes
• Sloan Fellow from London Business School and a microbiologist by training (University of Illinois at Urbana-Champaign, Institut Pasteur Paris, and University of Lille Flandres-Artois).
• Consulting, Partnering & Fund Raising, Founder, Managing Director, NxR Biotechnologies, Switzerland.
• Dr. Vertès is a strategy and business development consultant for cell therapeutic biotech companies, and works to enable seed funding in the field. Focusing on technology deployment and innovation commercialization, he has contributed to both industrial and pharmaceutical biotechnology, in different functions including research, manufacturing, contract research, and strategic alliances in pharmaceuticals (Lilly, Pfizer, Roche).
• Championed radical innovation for bringing to patients disease-modifying, paradigm-changing therapeutics such as siRNA, and led in a scientific and business manner Roche’s global cell therapeutics strategy and implementation team resulting in Roche’s entry in 2010 in the field of regenerative medicine.
• Member, Industry Committee-Europe, Tissue Engineering and Regenerative Medicine International Society
• Co-Editor, Stem Cells in Regenerative Medicine: Science, Regulation and Business Strategies (Wiley, 2015).
Affiliations and Expertise
Nathan Dowden
Affiliations and Expertise
Devyn Smith
• Responsible for all cell & gene therapy products, as well as previously developing Pfizer’s Regenerative Medicine program.
• PhD in Genetics from Harvard Medical School.
• Adjunct faculty member at Northeastern University.
Affiliations and Expertise
Nasib Qureshi
Affiliations and Expertise
Ratings and Reviews
Latest reviews
(Total rating for all reviews)
kishor d. Fri Aug 17 2018
Second-Generation Cell and Gene-based Therapies
wise one