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Screening Methods in Pharmacology - 1st Edition - ISBN: 9780127042527, 9781483264233

Screening Methods in Pharmacology

1st Edition

Volume II

Editors: Robert Turner Peter Hebborn
eBook ISBN: 9781483264233
Imprint: Academic Press
Published Date: 28th January 1971
Page Count: 308
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Screening Methods in Pharmacology, Volume II is a collection of papers that presents practical techniques and information on the selection of a screening program for a particular pharmacological activity. The book contains the most reliable, simplest, and the most preferred screening methods in pharmacology. The text presents screening methods for alpha and beta Adrenergic blocking agents; compounds for antianginal activity; topical products for excessive eccrine sweating; antidepressant agents; and agents with analgesic and analgesic antagonist activity. Pharmacologists, pharmacists, researchers, and physicians will find this book a good source of information.

Table of Contents


List of Contributors


Contents of Volume I


Chapter 1. α-Adrenergic Blocking Agents

I. General Considerations

II. Methods


Chapter 2. ß-Adrenergic Blocking Agents

I. Introduction

II. Methods of Screening for ß-Adrenergic Blocking Agents

III. Classification of New ß-Adrenergic Blocking Agents

IV. Metabolic Effects of ß-Adrenergic Blocking Agents

V. Comparison of Methods

VI. Use of ß-Adrenergic Blocking Agents in Therapy


Chapter 3. Agents Acting on Coronary Blood Vessels

I. Introduction

II. Isolated Organs

III. Measurement of Coronary Blood Flow of the Heart in Situ

IV. Experimental Coronary Insufficiency

V. Concluding Remarks


Chapter 4. Agents with Kinin-like Activity

I. Introduction

II. Methods for Assaying Components of the Plasma Kinin System


Chapter 5. Androgenic and Anabolic Agents

I. Introduction

II. Methods


Chapter 6. Estrogenic and Antiestrogenic Agents

I. Introduction

II. Screening Methods for Estrogens

III. Screening Methods for Antiestrogens


Chapter 7. Anovulatory Agents

I. Introduction

II. Screening Assays


Chapter 8. Progestational Agents

I. Introduction

IL Screening Methods for Progestational Agents

III. General Comments


Chapter 9. Antihyperlipidemic Agents

I. Introduction

II. Historical Review

III. Etiology

IV. Therapy in Atherosclerosis

V. Screening Methods


Chapter 10. Immunosuppressive Agents

I. Introduction

II. Screening Procedures


Chapter 11. Agents Affecting Mucociliary Activity

I. Introduction

II. In Vitro Methods

III. In Vivo Methods


Chapter 12. Antiperspirant Agents

I. Introduction

II. Methods


Chapter 13. Antidepressant Agents

I. Introduction

II. Antagonism of the Effects of Reserpine-like Drugs

III. Potentiation of Phenethylamines

IV. Muricide Antagonism in Rats

V. Effects of Antidepressants on the Autonomic Nervous System

VI. Inhibition of Norepinephrine Uptake and Release

VII. Monoamine Oxidase Inhibition


Chapter 14. Agents with Analgesic Activity and Dependence Liability

I. Introduction

II. Analgesic Evaluation

III. Characterization for Abuse Potential


Chapter 15. Natriuretic and Antihypertensive Agents Screened by Sequential Methods

I. Introduction

II. The Design of a Sequential Procedure

III. Use of Controls

IV. Examples of Design and Use of Sequential Procedures


Author Index

Subject Index


No. of pages:
© Academic Press 1971
28th January 1971
Academic Press
eBook ISBN:

About the Editors

Robert Turner

Dr. Robert Turner is currently the owner and CEO of Network Neurology in Charleston SC. He is also Associate Clinical Professor of Neurosciences at the Medical University of South Carolina in Charleston, as well as an Associate Researcher with the MIND Research Institute in Irvine CA. Dr Turner maintains a full-time clinical, teaching, and neurophysiology practice with patients throughout the southeastern region of the United States. While continuing full time work at MUSC since 1997, he obtained a Master’s degree in clinical research (epidemiology & biostatistics) in 2003 in the MUSC College of Graduate Studies, and has since then been actively involved in ongoing clinical research with collaborative studies in non-invasive neurostimulation and neuromodulation techniques as well as advanced techniques of EEG source analysis. Current research involves collaborating with colleagues in Charleston, Cape Town, South Africa, Mexico City, Bejing, and with several academic practices throughout the United States.

Dr Turner began as a music and foreign language major in college, changing over to pre-medicine in his 3rd year. During medical school, he also pursued Master’s training in Piano Performance at the University of Nebraska at Omaha Graduate School. After Medical School, his postgraduate training consisted of internship/residency in Pediatrics followed by two fellowships, one in Adult/Child Neurology, and the second in Clinical Neurophysiology/EMG/Neuromuscular Disorders, and his current clinical/research emphases are pediatric epilepsy/epileptogenesis, the non-linear effects of auditory and music stimulation on the brain, as well as neuromodulation techniques. He continues to pursue his love of music, and is an accomplished classical pianist. He has received numerous awards and honors in Charleston over the past 16 years, including multiple Faculty Excellence Awards for teaching, AREA Awards for excellence in ambulatory care, Golde Apple Nominations and Awards, and double honors in humanism with the AAMC Humanism in Medicine Award and the Leonard Tow Humanism in Medicine Award

Dr. Turner is multiply Board-Certificated by the National Board of Medical Examiners, became a certified member of the American Society of Neurorehabilitation in 1992, and has eight medical specialty boards certifications:

1. American Board of Psychiatry and Neurology With Special Qualification in Child Neurology,

2. American Board of Pediatrics,

3. American Board of Electrodiagnostic Medicine,

4. American Board of Clinical Neurophysiology,

5. American Board of Psychiatry and Neurology With Added Qualification in Clinical Neurophysiology,

6. American Board of Psychiatry and Neurology With Added Qualification in Neurodevelopmental Disabilities ,

7. Quantitative Electroencephalograpy (QEEG) Certification Board, and

8. American Board of Psychiatry and Neurology With Added Qualification in Epilepsy.

Affiliations and Expertise

Owner and CEO, Network Neurology, Charleston SC, USA

Peter Hebborn

Ratings and Reviews