COVID-19 Update: We are currently shipping orders daily. However, due to transit disruptions in some geographies, deliveries may be delayed. To provide all customers with timely access to content, we are offering 50% off Science and Technology Print & eBook bundle options. Terms & conditions.
Scientific Principles of Adipose Stem Cells - 1st Edition - ISBN: 9780128193761

Scientific Principles of Adipose Stem Cells

1st Edition

0.0 star rating Write a review
Editors: Lauren Kokai Kacey Marra J. Peter Rubin
Paperback ISBN: 9780128193761
Imprint: Academic Press
Published Date: 3rd December 2020
Page Count: 350
Sales tax will be calculated at check-out Price includes VAT/GST

Institutional Subscription

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Description

Scientific Principles of Adipose Stem Cells provides readers with in-depth and expert knowledge on adipose stem cells, their developmental biologic origins, foundational research on ASC signaling mechanisms and immunomodulatory properties, and clinical insights into applications in regenerative medicine.  Topics covered include basic adipose stem cell developmental biology and mechanisms of regulating self-renewal and activation in the stem cell niche, important methods for isolation and characterizing ASCs, and data on the impact on human demographics (age, sex, BMI) on ASC phenotype. A section devoted to ASC biology, ASCs for stem cell therapy and regenerative medicine, and ASCs in tissue engineering applications are also included.

The book is written for scientists and clinicians who are broadly familiar with stem cells and basic cell biology principles and those seeking advanced information on adipose stem cells.

Key Features

  • Coverage of basic adipose stem cell developmental biology (maturation process during embryogenesis) and mechanisms of regulating self-renewal and activation in the stem cell niche
  • Includes important methods for isolation and characterizing ASCs, as well as known data any impact of human demographics (age, sex, BMI) on ASC phenotype
  • An entire section dedicated to ASC biology, additional sections will be devoted to ASCs for stem cell therapy and regenerative medicine, as well as ASCs in tissue engineering applications

Readership

Academics and clinicians working with adipose tissue and adipose stem cells. Also, likely includes companies working to commercialize stem cell products. This may include (but is not limited to) stem cell biologists, tissue engineers, plastic surgeons. Many Universities feature tissue engineering and stem cell courses. This book will likely be purchased as a physical copy and/or e-book to support these classes

Table of Contents

Part 1. Introduction and Front Matter
1. Historical Review of Adipose Stem Cells: Discovery and Important Concepts

Part 2. Basic Biology of Adipose Stem Cells
2. The Developmental Origins of Adipose Tissue
3. Establishing the Adipose Stem Cell Identity: Characterization Assays and Functional Properties
4. Maintenance of Adipose Stem Cells in the Stem Cell Niche: Molecular Mechanisms Regulating Self-Renewal and Activation
5. Adipose Stem Cells in Beige and Brown Fat
6. Adipose Stem Cells and Aging
7. Adipose Tissue and Stem Cell Secretomes
8. Adipose MUSE Cell Expression of Pluripotency Genes and Plasticity
9. Adipose Mesenchymal Stem Cell Homing Mechanisms after Injury
10. Bioreactors and MPS systems for adipose-based pharmacologic screening 

Part 3. Adipose Cell Therapy and Regenerative Medicine
11. Animal Models in Adipose Stem Cell Research
12. Adipose Stem Cells and Donor Demographics: Impact of Anatomic Location, Donor Sex, Race, BMI and Health
13. Adipose Stem Cell Immunomodulatory Properties
14. Clinical Experience with Adipose Tissue enriched with Adipose Stem Cells
15. Adipose Stem Cells for Wound Healing and Fibrosis
16. Oncologic Safety of Adipose Cell Therapy
17. FDA Regulations on Adipose Cell Use in Clinical Trials and Clinical Translation

Part 4. Engineering with Adipose Stem Cell
18. Biomaterial Control of Adipose Stem Cell Differentiation
19. Methods for Genetically Modifying Adipose Stem Cells
20. Adipose Stem Cells for Bone and Cartilage Engineering
21. Hematopoietic Potential of Adipose Stem Cells
22. Adipose Stem Cells for Vascular Engineering
23. Adipose Stem Cells for Peripheral Nerve Engineering

Part 5. Conclusions and Back Matter
24. Future Research in Adipose Stem Cells and Regenerative Medicine

Details

No. of pages:
350
Language:
English
Copyright:
© Academic Press 2021
Published:
3rd December 2020
Imprint:
Academic Press
Paperback ISBN:
9780128193761

About the Editors

Lauren Kokai

Dr. Kokai is co-director of the Adipose Stem Cell Center at the University of Pittsburgh, faculty of the McGowan Institute of Regenerative Medicine (MIRM) and research faculty member in the Department of Plastic Surgery, School of Medicine. Dr. Kokai has a broad background in soft tissue engineering with specific training in development of novel biomaterials and drug delivery systems for adipose tissue regeneration and use of mesenchymal stem cells for tissue engineering and cell therapy applications. She has extensive experience in developing bioassays for biologic product development and has led collaborations with industry partners to transition preclinical research into commercialized products. Dr. Kokai is a co-Investigator in an NIH funded line of research aimed at developing cell-based methods for clinical soft tissue reconstruction after cancer therapy.

Affiliations and Expertise

McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA

Kacey Marra

Dr. Marra is an Associate Professor in the Department of Plastic Surgery (Primary), and Department of Bioengineering (Secondary), at the University of Pittsburgh. Dr. Marra’s academic training was in the areas of polymer chemistry, biomaterials and tissue engineering. She is the Director of the Plastic Surgery Research Laboratory (since 2002) and a core faculty member in the McGowan Institute for Regenerative Medicine, where she has served as a member of the Executive Committee since 2004. She has a publication record of 114 peer-reviewed publications, 24 reviews, 14 book chapters, and 4 patents, and over 570 abstracts in the areas of nerve regeneration, adipose stem cells, bioreactors, tissue engineering, and wound healing. Her funding includes NIH, NSF, and DoD grants in the area of regenerative medicine (including the Armed Forces Institute for Regenerative Medicine, (AFIRM)). She is the Enabling Technology Core Focus Area Leader in AFIRM II. She was Co-Chair of the 2015 Tissue Engineering and Regenerative Medicine International Society (TERMIS) World Congress, held in Boston.

Affiliations and Expertise

McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA

J. Peter Rubin

Dr. Rubin is endowed Professor of Plastic Surgery and Professor of Bioengineering, at the University of Pittsburgh with a faculty appointment with the McGowan Institute of Regenerative Medicine (MIRM). Dr. Rubin developed a basic science research program in the biology of adipose-derived stem cells and serves as Co-Director of the Adipose Stem Cell Center at the University of Pittsburgh. Dr. Rubin holds leadership positions in national and international plastic surgery societies, is the principal investigator in an NIH-funded line of research aimed at developing cell based methods for clinical soft tissue reconstruction after cancer therapy and holds two FDA cell therapy IDE protocols and an IND, all as sponsor/ investigator. Dr. Rubin’s many scientific leadership positions include past president of the International Society of Adipose Therapeutics and Science and past Chairman of the Plastic Surgery Research Council. He has received numerous awards for research, including the highly competitive Gingrass Award from the Plastic Surgery Research Council. He is the recipient of the American Association of Plastic Surgeons Academic Scholar Award, and the Plastic Surgery Educational Foundation Award for Outstanding Achievement in Basic and Translational Science. In 2007, Dr. Rubin was selected to receive a Presidential Early Career Award for Scientists and Engineers (PECASE). Dr. Rubin contributes expertise in scientific models assessing the use of adult adipose stem cell therapies for tissue engineering and regenerative applications

Affiliations and Expertise

Director of Body Contouring Program, Associate Professor of Surgery, Chief, Division of Plastic and Reconstructive Surgery Chief and Endowed Professor Department of Plastic and Reconstructive Surgery

Ratings and Reviews