Schering Workshop on Pharmacokinetics, Berlin, May 8 and 9, 1969

Schering Workshop on Pharmacokinetics, Berlin, May 8 and 9, 1969

Advances in the Biosciences

1st Edition - June 18, 1970

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  • Editor: Gerhard Raspé
  • eBook ISBN: 9781483158266

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Advances in the Biosciences 5: Schering Workshop on Pharmacokinetics, Berlin, May 8 and 9, 1969 is a collection of papers presented at the Schering Workshop on Pharmacokinetics held in Berlin, Germany, on May 8 and 9, 1969. Contributors focus on advances in the field of pharmacokinetics, including the use of digital computers in defining pharmacokinetic parameters and of mathematical models in the study of steroid dynamics. The pharmacokinetics of acetazolamide and endogenous substances is also described. This book is comprised of 19 chapters and begins with an overview of the basic concepts and experimental methods of pharmacokinetics, followed by a discussion on the general physico-chemical aspects of drug distribution. Subsequent chapters explore multiple dose elimination kinetics and drug accumulation in patients with normal and impaired kidney function; the application of analog and digital computers in pharmacokinetics; use of mathematical tools in defining pharmacokinetic parameters; and measurement of enteric absorption rate using a double tracer technique. Mathematical and statistical problems in pharmacokinetics are also presented. This monograph will be a useful resource for pharmacologists and biologists.

Table of Contents

  • Introduction


    Basic Concepts and Experimental Methods of Pharmacokinetics

    General Physico-Chemical Aspects of Drug Distribution

    Multiple Dose Elimination Kinetics and Drug Accumulation in Patients with Normal and with Impaired Kidney Function

    The Application of the Analog Computer in Pharmacokinetics

    Use of Digital Computers in Defining Pharmacokinetic Parameters

    Use of Mathematical Tools in Defining Pharmacokinetic Parameters

    Mathematical and Statistical Problems in Pharmacokinetics

    The Formulation of Models to explain Blood and Tissue Data on Distribution of Drugs and Tracers (With special Reference to Multi-Compartment Models)

    An Explicit Function for Rate Constant of Entrance Concerning a Two-Compartment-Model

    Mathematical Models in the Study of Steroid Dynamics

    The Measurement of Enteric Absorption Rate using a Double Tracer Technique

    The Systematic Influence of Elimination

    Pharmacokinetics of Endogenous Substances

    The Pharmacokinetics of Acetazolamide in Relation to Its Use in the Treatment of Glaucoma and to Its Effects as an Inhibitor of Carbonic Anhydrases

    Pharmacokinetics in Clinical Drug Research

    Pharmacokinetics of Human Drug Research

    Panel Discussion

    Closing Address



Product details

  • No. of pages: 296
  • Language: English
  • Copyright: © Pergamon 1970
  • Published: June 18, 1970
  • Imprint: Pergamon
  • eBook ISBN: 9781483158266

About the Editor

Gerhard Raspé

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