Advances in the Biosciences 5: Schering Workshop on Pharmacokinetics, Berlin, May 8 and 9, 1969 is a collection of papers presented at the Schering Workshop on Pharmacokinetics held in Berlin, Germany, on May 8 and 9, 1969. Contributors focus on advances in the field of pharmacokinetics, including the use of digital computers in defining pharmacokinetic parameters and of mathematical models in the study of steroid dynamics. The pharmacokinetics of acetazolamide and endogenous substances is also described. This book is comprised of 19 chapters and begins with an overview of the basic concepts and experimental methods of pharmacokinetics, followed by a discussion on the general physico-chemical aspects of drug distribution. Subsequent chapters explore multiple dose elimination kinetics and drug accumulation in patients with normal and impaired kidney function; the application of analog and digital computers in pharmacokinetics; use of mathematical tools in defining pharmacokinetic parameters; and measurement of enteric absorption rate using a double tracer technique. Mathematical and statistical problems in pharmacokinetics are also presented. This monograph will be a useful resource for pharmacologists and biologists.
Introduction Opening Basic Concepts and Experimental Methods of Pharmacokinetics General Physico-Chemical Aspects of Drug Distribution Multiple Dose Elimination Kinetics and Drug Accumulation in Patients with Normal and with Impaired Kidney Function The Application of the Analog Computer in Pharmacokinetics Use of Digital Computers in Defining Pharmacokinetic Parameters Use of Mathematical Tools in Defining Pharmacokinetic Parameters Mathematical and Statistical Problems in Pharmacokinetics The Formulation of Models to explain Blood and Tissue Data on Distribution of Drugs and Tracers (With special Reference to Multi-Compartment Models) An Explicit Function for Rate Constant of Entrance Concerning a Two-Compartment-Model Mathematical Models in the Study of Steroid Dynamics The Measurement of Enteric Absorption Rate using a Double Tracer Technique The Systematic Influence of Elimination Pharmacokinetics of Endogenous Substances The Pharmacokinetics of Acetazolamide in Relation to Its Use in the Treatment of Glaucoma and to Its Effects as an Inhibitor of Carbonic Anhydrases Pharmacokinetics in Clinical Drug Research Pharmacokinetics of Human Drug Research Panel Discussion Closing Address Lecturers Participants
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- © Pergamon 1970
- 18th June 1970
- eBook ISBN: