Schering Workshop on Pharmacokinetics, Berlin, May 8 and 9, 1969 - 1st Edition - ISBN: 9780080175485, 9781483158266

Schering Workshop on Pharmacokinetics, Berlin, May 8 and 9, 1969

1st Edition

Advances in the Biosciences

Editors: Gerhard Raspé
eBook ISBN: 9781483158266
Imprint: Pergamon
Published Date: 18th June 1970
Page Count: 296
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Description

Advances in the Biosciences 5: Schering Workshop on Pharmacokinetics, Berlin, May 8 and 9, 1969 is a collection of papers presented at the Schering Workshop on Pharmacokinetics held in Berlin, Germany, on May 8 and 9, 1969. Contributors focus on advances in the field of pharmacokinetics, including the use of digital computers in defining pharmacokinetic parameters and of mathematical models in the study of steroid dynamics. The pharmacokinetics of acetazolamide and endogenous substances is also described. This book is comprised of 19 chapters and begins with an overview of the basic concepts and experimental methods of pharmacokinetics, followed by a discussion on the general physico-chemical aspects of drug distribution. Subsequent chapters explore multiple dose elimination kinetics and drug accumulation in patients with normal and impaired kidney function; the application of analog and digital computers in pharmacokinetics; use of mathematical tools in defining pharmacokinetic parameters; and measurement of enteric absorption rate using a double tracer technique. Mathematical and statistical problems in pharmacokinetics are also presented. This monograph will be a useful resource for pharmacologists and biologists.

Table of Contents


Introduction

Opening

Basic Concepts and Experimental Methods of Pharmacokinetics

General Physico-Chemical Aspects of Drug Distribution

Multiple Dose Elimination Kinetics and Drug Accumulation in Patients with Normal and with Impaired Kidney Function

The Application of the Analog Computer in Pharmacokinetics

Use of Digital Computers in Defining Pharmacokinetic Parameters

Use of Mathematical Tools in Defining Pharmacokinetic Parameters

Mathematical and Statistical Problems in Pharmacokinetics

The Formulation of Models to explain Blood and Tissue Data on Distribution of Drugs and Tracers (With special Reference to Multi-Compartment Models)

An Explicit Function for Rate Constant of Entrance Concerning a Two-Compartment-Model

Mathematical Models in the Study of Steroid Dynamics

The Measurement of Enteric Absorption Rate using a Double Tracer Technique

The Systematic Influence of Elimination

Pharmacokinetics of Endogenous Substances

The Pharmacokinetics of Acetazolamide in Relation to Its Use in the Treatment of Glaucoma and to Its Effects as an Inhibitor of Carbonic Anhydrases

Pharmacokinetics in Clinical Drug Research

Pharmacokinetics of Human Drug Research

Panel Discussion

Closing Address

Lecturers

Participants

Details

No. of pages:
296
Language:
English
Copyright:
© Pergamon 1970
Published:
Imprint:
Pergamon
eBook ISBN:
9781483158266

About the Editor

Gerhard Raspé